| Sequence 1: | NP_572358.1 | Gene: | mAChR-C / 31626 | FlyBaseID: | FBgn0029909 | Length: | 371 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_000852.1 | Gene: | HRH1 / 3269 | HGNCID: | 5182 | Length: | 487 | Species: | Homo sapiens |
| Alignment Length: | 474 | Identity: | 88/474 - (18%) |
|---|---|---|---|
| Similarity: | 157/474 - (33%) | Gaps: | 183/474 - (38%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 44 TSFGAGHLLWLAINAFLFVLI-LGGNILTIVAVRTCRHLRSVISNLFILSLAVSDFCVG-LALPY 106
Fly 107 HLVFYMGSDIGAMRGPCLLRFFLLICACCVSMLTLISIAVDRYIAVVYALHYRRYMTRRVAYSII 171
Fly 172 IFNWCLGALVALLPVFWNRWPDAQA------CEFD-------EVLAPGYIAGVITPGFVIIWICM 223
Fly 224 FLVY------------------------------------------WRIMREASKQA-------- 238
Fly 239 -----LRLRQSVVYN-------------------------------------------------- 248
Fly 249 --------------------TDEATT-----------------------------------MRNL 258
Fly 259 LLHPDWKSVQIVVFIMGCFTLCWLPYFCVAIAQLFSICQS--SSMIYKTTFSLAIANSALNPIIY 321
Fly 322 SWKNSGFRRAFVQTLCCRT 340 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| mAChR-C | NP_572358.1 | 7tm_4 | 61..332 | CDD:304433 | 82/447 (18%) |
| 7tm_1 | 67..321 | CDD:278431 | 76/429 (18%) | ||
| HRH1 | NP_000852.1 | 7tmA_Histamine_H1R | 28..479 | CDD:320178 | 83/456 (18%) |
| TM helix 1 | 30..54 | CDD:320178 | 7/23 (30%) | ||
| TM helix 2 | 63..85 | CDD:320178 | 10/21 (48%) | ||
| TM helix 3 | 101..123 | CDD:320178 | 3/21 (14%) | ||
| Important for agonist binding | 107..112 | 1/4 (25%) | |||
| TM helix 4 | 146..162 | CDD:320178 | 4/15 (27%) | ||
| TM helix 5 | 188..211 | CDD:320178 | 4/25 (16%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 238..291 | 5/52 (10%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 345..379 | 4/33 (12%) | |||
| TM helix 6 | 414..436 | CDD:320178 | 10/23 (43%) | ||
| Important for agonist binding | 424..428 | 2/3 (67%) | |||
| TM helix 7 | 447..472 | CDD:320178 | 9/24 (38%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 1 | 0.930 | - | - | C165144810 | |
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 0 | 0.000 | Not matched by this tool. | |||
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 2 | 1.840 | |||||