DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mAChR-C and Gpr119

DIOPT Version :9

Sequence 1:	NP_572358.1	Gene:	mAChR-C / 31626	FlyBaseID:	FBgn0029909	Length:	371	Species:	Drosophila melanogaster
Sequence 2:	NP_861435.1	Gene:	Gpr119 / 302813	RGDID:	727808	Length:	468	Species:	Rattus norvegicus

Alignment Length:	303	Identity:	82/303 - (27%)
Similarity:	139/303 - (45%)	Gaps:	23/303 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 TSFGAGHLLWLAINAFLFVLILGGNILTIVAVRTCRHLRSVISNLFILSLAVSDFCVGLALPYHL 108
            :||..|.:|     |.|.:||:..|.|.:||:....:....:...|.|:|||:|..:|:|:...:
  Rat     3 SSFSFGVIL-----AVLTILIIAVNALVVVAMLLSIYKNDGVGLCFTLNLAVADTLIGVAISGLV 62

  Fly   109 VFYMGSDI-GAMRGPCLLRFFLLICACCVSMLTLISIAVDRYIAVVYALHYRRYMTRRVAYSIII 172
            ...:.|.. ...:..|.||...:..:...|:||::.||.|||:|:...|.|.:.|...||...|.
  Rat    63 TDQLSSSAQHTQKTLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIA 127

  Fly   173 FNWCLGALVALLPV---FWNRWPDAQACEFDEVLAPGYIAGVITPGFVIIWICMFLVYWRIMREA 234
            ..|.:..|:..||:   .:.:......|.|..|..|.::..:...||....:.....|..:::.|
  Rat   128 GLWLISYLIGFLPLGVSIFQQTTYHGPCTFFAVFHPRFVLTLSCAGFFPAVLLFVFFYCDMLKIA 192

  Fly   235 SKQALRLRQSVVYNTDEATTMRNLLLHP----DWKSVQIVVFIMGCFTLCWLPYFCVAIAQL-FS 294
            |..:..:|:     .:.|..|......|    |:|:|:.|..::|.|||.|.|:...:|.|: ..
  Rat   193 SVHSQHIRK-----MEHAGAMVGACRPPRPVNDFKAVRTVSVLIGSFTLSWSPFLITSIVQVACH 252

  Fly   295 ICQSSSMIYKTTFSLAIANSALNPIIYSWKNSGFRRAFVQTLC 337
            .|....::.|..:.|.:.||.|||:||::    ::|...|.||
  Rat   253 KCCLYQVLEKYLWLLGVGNSLLNPLIYAY----WQREVRQQLC 291

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-C	NP_572358.1	7tm_4	61..332	CDD:304433	73/279 (26%)
mAChR-C	NP_572358.1	7tm_1	67..321	CDD:278431	68/262 (26%)
Gpr119	NP_861435.1	7tmA_GPR119_R_insulinotropic_receptor	6..290	CDD:320232	78/297 (26%)
		TM helix 1	7..31	CDD:320232	10/28 (36%)
		TM helix 2	41..62	CDD:320232	8/20 (40%)
		TM helix 3	79..101	CDD:320232	6/21 (29%)
		TM helix 4	124..140	CDD:320232	3/15 (20%)
		TM helix 5	163..186	CDD:320232	3/22 (14%)
		TM helix 6	224..246	CDD:320232	8/21 (38%)
		TM helix 7	258..283	CDD:320232	9/28 (32%)
		KLF18_N	346..>453	CDD:410566
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	2	1.870