DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mAChR-C and Taar7e

DIOPT Version :9

Sequence 1:	NP_572358.1	Gene:	mAChR-C / 31626	FlyBaseID:	FBgn0029909	Length:	371	Species:	Drosophila melanogaster
Sequence 2:	NP_783180.2	Gene:	Taar7e / 294133	RGDID:	631394	Length:	358	Species:	Rattus norvegicus

Alignment Length:	351	Identity:	91/351 - (25%)
Similarity:	154/351 - (43%)	Gaps:	35/351 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAFTSSSSPAWDYRS--SPEALGVVPFLWQHQNATETPTEITLQATSFGAGHLLWLAINAFLFVL 63
            ||...:|.| ||..|  |.:.|........::|...:    .:::.......|:..|:..|..||
  Rat     1 MATDDASFP-WDQDSILSRDLLSASSSQLCYENLNRS----CIRSPYSPGPRLILHAVFGFSAVL 60

  Fly    64 ILGGNILTIVAVRTCRHLRSVISNLFILSLAVSDFCVGL-ALPYHLV------FYMGSDIGAMRG 121
            .:.||:|.:.::...|.|.|. :|..:.|||.:|..||| .:|:.:|      :|.| ||
  Rat    61 AVCGNLLVMTSILHFRQLHSP-ANFLVASLACADLLVGLTVMPFSMVRSVEGCWYFG-DI----- 118

  Fly   122 PCLLRFFLLICACCVSMLTLISIAVDRYIAVVYALHYRRYMTRRVAYSIIIFNWCLGALVALLPV 186
            .|.......:..|..|:..|..|:|||||||...|.|....|..|:...|.|:|.|..:.:...:
  Rat   119 YCKFHSSFDVSFCYCSLFHLCFISVDRYIAVSDPLIYPTRFTASVSGKCITFSWFLSIIYSFSLL 183

  Fly   187 FWNRWPDAQACEFDEVLAPGYIAG---VITPGFVIIWICMFL--------VYWRIMREASKQALR 240
            :...   ::|...|.|.|...:.|   .:...:|.|...:||        ||.::...|.:||..
  Rat   184 YTGA---SEAGLEDLVSALTCVGGCQLAVNQSWVFINFLLFLVPTLVMMTVYSKVFLIAKQQAQN 245

  Fly   241 LRQSVVYNTDEATTMRNLLLHPDWKSVQIVVFIMGCFTLCWLPYFCVAIAQLFSICQSSSMIYKT 305
            :.:........:.:.::.:...:.|:.:.:...:..|.|.|||||..:|...|....:.:.:|:.
  Rat   246 IEKIGKQTARASESYKDRVAKRERKAAKTLGITVAAFLLSWLPYFIDSIIDAFLGFITPTYVYEI 310

  Fly   306 TFSLAIANSALNPIIYSWKNSGFRRA 331
            ...:|..|||:||:||::....||:|
  Rat   311 LVWIAYYNSAMNPLIYAFFYPWFRKA 336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-C	NP_572358.1	7tm_4	61..332	CDD:304433	78/289 (27%)
mAChR-C	NP_572358.1	7tm_1	67..321	CDD:278431	71/271 (26%)
Taar7e	NP_783180.2	7tm_GPCRs	49..337	CDD:421689	80/298 (27%)
		TM helix 1	49..75	CDD:410628	7/25 (28%)
		TM helix 2	82..108	CDD:410628	10/25 (40%)
		TM helix 3	120..150	CDD:410628	11/29 (38%)
		TM helix 4	162..185	CDD:410628	5/22 (23%)
		TM helix 5	209..238	CDD:410628	6/28 (21%)
		TM helix 6	266..296	CDD:410628	9/29 (31%)
		TM helix 7	305..330	CDD:410628	9/24 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24249
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010