DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mAChR-C and Taar7h

DIOPT Version :9

Sequence 1:	NP_572358.1	Gene:	mAChR-C / 31626	FlyBaseID:	FBgn0029909	Length:	371	Species:	Drosophila melanogaster
Sequence 2:	NP_783177.1	Gene:	Taar7h / 294130	RGDID:	631385	Length:	358	Species:	Rattus norvegicus

Alignment Length:	352	Identity:	93/352 - (26%)
Similarity:	151/352 - (42%)	Gaps:	37/352 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAFTSSSSPAWDYRS--SPEALGVVPFLWQHQNATETPTEITLQATSFGAG-HLLWLAINAFLFV 62
            ||....|.| ||..|  |.:.|..:.....::|...:...     :.:..| .|:..|:..|..|
  Rat     1 MATDDESFP-WDQDSILSRDLLSALSPQLCYENLNRSCVR-----SPYSPGPRLILYAVFGFGAV 59

  Fly    63 LILGGNILTIVAVRTCRHLRSVISNLFILSLAVSDFCVGL-ALPYHLV------FYMGSDIGAMR 120
            |.:.||:|.:.::...|.|.|. :|..:.|||.:|..||| .:|:.:|      :|.|...
  Rat    60 LAVCGNLLVMTSILHFRQLHSP-ANFLVASLACADLLVGLTVMPFSMVRSVEGCWYFGDSY---- 119

  Fly   121 GPCLLRFFLLICACCVSMLTLISIAVDRYIAVVYALHYRRYMTRRVAYSIIIFNWCLGALVALLP 185
              |.|.....:..||.|:|.|..|:|||||||...|.|....|..|:...|.|:|.|..:.....
  Rat   120 --CKLHTSFDMSFCCSSLLHLCFISVDRYIAVSDPLIYPIRFTASVSGKCITFSWFLSIIYGFSL 182

  Fly   186 VFWNRWPDAQACEFDEVLAPGYIAGVITPG-----------FVIIWICMFLVYWRIMREASKQAL 239
            ::...   ::|...|.|.|...:.|...|.           |::..:.|..||.:|...|.:||.
  Rat   183 IYTGA---SEAGLKDLVSALSCVGGCQIPMNQSCVLINFLLFLVPTLVMMTVYSKIFLIAKQQAQ 244

  Fly   240 RLRQSVVYNTDEATTMRNLLLHPDWKSVQIVVFIMGCFTLCWLPYFCVAIAQLFSICQSSSMIYK 304
            .:.:.....|..:.:.::.:...:.|:.:.:...:..|.|.||||...:|...|....:.|.:|:
  Rat   245 NMEKMSKQTTRASDSYKDRVAKRERKAAKTLGIAVAAFLLSWLPYLIDSIIDAFLGFITPSYVYE 309

  Fly   305 TTFSLAIANSALNPIIYSWKNSGFRRA 331
            ....:...|||:||:||::....||.|
  Rat   310 ILVWIVYYNSAMNPLIYAFFYPWFRNA 336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-C	NP_572358.1	7tm_4	61..332	CDD:304433	79/289 (27%)
mAChR-C	NP_572358.1	7tm_1	67..321	CDD:278431	72/271 (27%)
Taar7h	NP_783177.1	7tm_4	54..344	CDD:304433	80/293 (27%)
Taar7h	NP_783177.1	7tm_1	64..326	CDD:278431	72/271 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24249
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010