Protein Alignment mAChR-C and Taar7a

DIOPT Version :10

• Sequence 1: NP_572358.1
• Gene: mAChR-C / 31626
• FlyBaseID: FBgn0029909
• Length: 371
• Species: Drosophila melanogaster
• Sequence 2: NP_783175.1
• Gene: Taar7a / 294125
• RGDID: 631387
• Length: 358
• Species: Rattus norvegicus
• Alignment Length: 365
• Identity: 94/365 - (25%)
• Similarity: 152/365 - (41%)
• Gaps: 64/365 - (17%)

  Fly     5 SSSSPAWDYRS-------SPEALGVVPFLWQHQNATETPTEITLQATSFGAGHLLWLAINAFLFV 62
            |:|||...|.:       ||.:.|              |..|......|||             |
  Rat    22 SASSPQLCYENLNGSCIRSPYSPG--------------PRLILYAVFGFGA-------------V 59

  Fly    63 LILGGNILTIVAVRTCRHLRSVISNLFILSLAVSDFCVGL-ALPYHLV------FYMGSDIGAMR 120
            |.:.||:|.:.::...|.|.|. :|..:.|||.:||.||| .:|:..|      :|.| |.....
  Rat    60 LAVCGNLLVMTSILHFRQLHSP-ANFLVASLACADFLVGLTVMPFSTVRSVEGCWYFG-DTYCKF 122

  Fly   121 GPCLLRFFLLICACCVSMLTLISIAVDRYIAVVYALHYRRYMTRRVAYSIIIFNWCLGALVALLP 185
            ..|....|     |..|:..|..|:|||||||...|.|....|..|:...|.|:|    |::::.
  Rat   123 HSCFEGSF-----CYSSIFHLCFISVDRYIAVSDPLIYPTRFTASVSGKCITFSW----LLSIIY 178

  Fly   186 VFWNRWPDAQACEFDEVLAPGYIAG----VITPGFVIIWICMFL--------VYWRIMREASKQA 238
            .|...:..|.....:::::.....|    .:...:|.|...:||        ||.:|...|.:||
  Rat   179 SFSLLYTGANEAGLEDLVSALTCVGGCQIAVNQSWVFINFLLFLVPTLVMMTVYSKIFLIAKQQA 243

  Fly   239 LRLRQSVVYNTDEATTMRNLLLHPDWKSVQIVVFIMGCFTLCWLPYFCVAIAQLFSICQSSSMIY 303
            ..:.:.....|..:.:.::.:...:.|:.:.:...:..|.|.|||||..:|...|....:.:.:|
  Rat   244 QNIEKMSKQTTRASESYKDRVAKRERKAAKTLGIAVAAFLLSWLPYFIDSIIDAFLGFITPTYVY 308

  Fly   304 KTTFSLAIANSALNPIIYSWKNSGFRRAFVQTLCCRTARQ 343
            :....:|..|||:||:||::....||:|....:..:..||
  Rat   309 EILVWIAYYNSAMNPLIYAFFYPWFRKAIKLIVTGKILRQ 348

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-C	NP_572358.1	7tm_classA_rhodopsin-like	53..325	CDD:410626	76/290 (26%)
		TM helix 1	53..78	CDD:410626	5/24 (21%)
		TM helix 2	86..111	CDD:410626	11/31 (35%)
		TM helix 3	123..153	CDD:410626	12/29 (41%)
		TM helix 4	166..185	CDD:410626	5/18 (28%)
		TM helix 5	204..229	CDD:410626	7/36 (19%)
		TM helix 6	261..291	CDD:410626	9/29 (31%)
		TM helix 7	300..325	CDD:410626	9/24 (38%)
Taar7a	NP_783175.1	7tm_GPCRs	49..337	CDD:475119	82/311 (26%)
		TM helix 1	50..74	CDD:320439	8/36 (22%)
		TM helix 2	83..105	CDD:320439	10/21 (48%)
		TM helix 3	121..143	CDD:320439	6/26 (23%)
		TM helix 4	166..182	CDD:320439	5/19 (26%)
		TM helix 5	210..233	CDD:320439	5/22 (23%)
		TM helix 6	272..294	CDD:320439	7/21 (33%)
		TM helix 7	305..330	CDD:320439	9/24 (38%)