DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mAChR-C and Taar6

DIOPT Version :9

Sequence 1:	NP_572358.1	Gene:	mAChR-C / 31626	FlyBaseID:	FBgn0029909	Length:	371	Species:	Drosophila melanogaster
Sequence 2:	NP_783174.1	Gene:	Taar6 / 294124	RGDID:	631384	Length:	345	Species:	Rattus norvegicus

Alignment Length:	337	Identity:	86/337 - (25%)
Similarity:	149/337 - (44%)	Gaps:	40/337 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 SSPEALGVVPFLWQHQNAT--ETPTEITLQATSFGAG-HLLWLAINAFLFVLILGGNILTIVAVR 76
            |||.|  |:...:::.|.:  :||         :..| .:|..|:..|..||.:.||:|.::::.
  Rat     5 SSPPA--VLQLCYENVNGSCVKTP---------YSPGPRVLLYAVFGFGAVLAVFGNLLVMISIL 58

  Fly    77 TCRHLRSVISNLFILSLAVSDFCVGLA-LPYHLV------FYMGSDIGAMRGPCLLRFFLLICAC 134
            ..:.|.|. :|..|.|||.:||.||:: :|:.:|      :|.|.........|.:.|      |
  Rat    59 HFKQLHSP-TNFLIASLACADFWVGVSVMPFSMVRSIESCWYFGRSFCTFHTCCDVAF------C 116

  Fly   135 CVSMLTLISIAVDRYIAVVYALHYRRYMTRRVAYSIIIFNWCLGALVALLPVFWNRWPDAQACEF 199
            ..|:..|..|::||||||...|.|....|..|:...|..:|.|....:....:...:.|......
  Rat   117 YSSLFHLSFISIDRYIAVTDPLVYPTKFTVSVSGICISISWILPLAYSGAVFYTGVYADGLEEVS 181

  Fly   200 DEVLAPGYIAGVITPGFVII--------WICMFLVYWRIMREASKQALRLRQSVVYNTDEAT--T 254
            |.|...|....|:...:|:|        .:.|.::|..|...|.:||.::  ..|.|..|::  :
  Rat   182 DAVNCVGGCQVVVNQNWVLIDFLSFLIPTLVMIILYGNIFLVARQQAKKI--ETVGNKAESSSES 244

  Fly   255 MRNLLLHPDWKSVQIVVFIMGCFTLCWLPYFCVAIAQLFSICQSSSMIYKTTFSLAIANSALNPI 319
            .:..:...:.|:.:.:...:..|.:.||||...::...|....:.:.||:.....|..|||:||:
  Rat   245 YKARVARRERKAAKTLGITVVAFMISWLPYSIDSLVDAFMGFITPAYIYEICVWCAYYNSAMNPL 309

  Fly   320 IYSWKNSGFRRA 331
            ||:.....|::|
  Rat   310 IYALFYPWFKKA 321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-C	NP_572358.1	7tm_4	61..332	CDD:304433	74/288 (26%)
mAChR-C	NP_572358.1	7tm_1	67..321	CDD:278431	68/270 (25%)
Taar6	NP_783174.1	7tmA_TAAR6_8_9	33..322	CDD:320439	77/298 (26%)
		TM helix 1	35..59	CDD:320439	7/23 (30%)
		TM helix 2	68..90	CDD:320439	10/21 (48%)
		TM helix 3	106..128	CDD:320439	6/27 (22%)
		TM helix 4	151..167	CDD:320439	3/15 (20%)
		TM helix 5	195..218	CDD:320439	3/22 (14%)
		TM helix 6	257..279	CDD:320439	5/21 (24%)
		TM helix 7	290..315	CDD:320439	10/24 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24249
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010