DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mAChR-C and Adora2b

DIOPT Version :9

Sequence 1:	NP_572358.1	Gene:	mAChR-C / 31626	FlyBaseID:	FBgn0029909	Length:	371	Species:	Drosophila melanogaster
Sequence 2:	NP_058857.2	Gene:	Adora2b / 29316	RGDID:	2050	Length:	332	Species:	Rattus norvegicus

Alignment Length:	329	Identity:	90/329 - (27%)
Similarity:	146/329 - (44%)	Gaps:	64/329 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 LWLAINAFLFVLILGGNILTIVAVRTCRHLRSVISNLFILSLAVSDFCVGL-ALPYHLVFYMG-- 113
            |::|:...:..|.:.||:|...||.....|::. :|.|::|||.:|..||| |:|:.:...:|
  Rat     9 LYVALELVIAALAVAGNVLVCAAVGASSALQTP-TNYFLVSLATADVAVGLFAIPFAITISLGFC 72

  Fly   114 SDIGAMRGPCLLRFFLLICACCVSMLT------LISIAVDRYIAVVYALHYRRYMTRRVAYSIII 172
            :|..:    ||   ||   ||.|.:||      |:::|||||:|:...|.|:..:|...|..||.
  Rat    73 TDFHS----CL---FL---ACFVLVLTQSSIFSLLAVAVDRYLAIRVPLRYKGLVTGTRARGIIA 127

  Fly   173 FNWCLGALVALLPVF-WNRWPDAQA------------------CEFDEVLAPGYIA-----GVIT 213
            ..|.|...:.|.|.. ||....|.:                  |.|:.|:...|:.     |.:.
  Rat   128 VLWVLAFGIGLTPFLGWNSKDRATSNCTEPGDGITNKSCCPVKCLFENVVPMSYMVYFNFFGCVL 192

  Fly   214 PGFVIIWICMFLVYWRIMREASKQALRLRQSVVYNTDEATTMRNLLLHPDWKSVQIVVFIMGCFT 278
            |..:|    |.::|.:|...|.||   |:...:......|..|.:      .:.:.:..|:|.|.
  Rat   193 PPLLI----MMVIYIKIFMVACKQ---LQHMELMEHSRTTLQREI------HAAKSLAMIVGIFA 244

  Fly   279 LCWLPYFCVAIAQLFSIC---QSSSMIYKTTFSLAIANSALNPIIYSWKNSGFRRAFVQTL---- 336
            |||||...:....||...   .....:......|:.|||.:||::|:::|..||.:|.:.:
  Rat   245 LCWLPVHAINCITLFHPALAKDKPKWVMNVAILLSHANSVVNPVVYAYRNRDFRYSFHRIISRYV 309

  Fly   337 CCRT 340
            .|:|
  Rat   310 LCQT 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-C	NP_572358.1	7tm_4	61..332	CDD:304433	85/306 (28%)
mAChR-C	NP_572358.1	7tm_1	67..321	CDD:278431	80/289 (28%)
Adora2b	NP_058857.2	7tm_GPCRs	8..301	CDD:421689	87/315 (28%)
		TM helix 1	9..35	CDD:410628	8/25 (32%)
		TM helix 2	42..69	CDD:410628	11/26 (42%)
		TM helix 3	78..108	CDD:410628	16/35 (46%)
		TM helix 4	122..140	CDD:410628	6/17 (35%)
		Agonist binding. /evidence=ECO:0000250	173..182		2/8 (25%)
		TM helix 5	179..209	CDD:410628	7/33 (21%)
		TM helix 6	227..257	CDD:410628	9/35 (26%)
		Agonist binding. /evidence=ECO:0000250	247..254		3/6 (50%)
		Agonist binding. /evidence=ECO:0000250	266..276		0/9 (0%)
		TM helix 7	269..294	CDD:410628	7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D252862at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920