Protein Alignment mAChR-C and Adora2b

DIOPT Version :10

• Sequence 1: NP_572358.1
• Gene: mAChR-C / 31626
• FlyBaseID: FBgn0029909
• Length: 371
• Species: Drosophila melanogaster
• Sequence 2: NP_058857.2
• Gene: Adora2b / 29316
• RGDID: 2050
• Length: 332
• Species: Rattus norvegicus
• Alignment Length: 329
• Identity: 90/329 - (27%)
• Similarity: 146/329 - (44%)
• Gaps: 64/329 - (19%)

  Fly    52 LWLAINAFLFVLILGGNILTIVAVRTCRHLRSVISNLFILSLAVSDFCVGL-ALPYHLVFYMG-- 113
            |::|:...:..|.:.||:|...||.....|::. :|.|::|||.:|..||| |:|:.:...:|
  Rat     9 LYVALELVIAALAVAGNVLVCAAVGASSALQTP-TNYFLVSLATADVAVGLFAIPFAITISLGFC 72

  Fly   114 SDIGAMRGPCLLRFFLLICACCVSMLT------LISIAVDRYIAVVYALHYRRYMTRRVAYSIII 172
            :|..:    ||   ||   ||.|.:||      |:::|||||:|:...|.|:..:|...|..||.
  Rat    73 TDFHS----CL---FL---ACFVLVLTQSSIFSLLAVAVDRYLAIRVPLRYKGLVTGTRARGIIA 127

  Fly   173 FNWCLGALVALLPVF-WNRWPDAQA------------------CEFDEVLAPGYIA-----GVIT 213
            ..|.|...:.|.|.. ||....|.:                  |.|:.|:...|:.     |.:.
  Rat   128 VLWVLAFGIGLTPFLGWNSKDRATSNCTEPGDGITNKSCCPVKCLFENVVPMSYMVYFNFFGCVL 192

  Fly   214 PGFVIIWICMFLVYWRIMREASKQALRLRQSVVYNTDEATTMRNLLLHPDWKSVQIVVFIMGCFT 278
            |..:|    |.::|.:|...|.||   |:...:......|..|.:      .:.:.:..|:|.|.
  Rat   193 PPLLI----MMVIYIKIFMVACKQ---LQHMELMEHSRTTLQREI------HAAKSLAMIVGIFA 244

  Fly   279 LCWLPYFCVAIAQLFSIC---QSSSMIYKTTFSLAIANSALNPIIYSWKNSGFRRAFVQTL---- 336
            |||||...:....||...   .....:......|:.|||.:||::|:::|..||.:|.:.:
  Rat   245 LCWLPVHAINCITLFHPALAKDKPKWVMNVAILLSHANSVVNPVVYAYRNRDFRYSFHRIISRYV 309

  Fly   337 CCRT 340
            .|:|
  Rat   310 LCQT 313

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-C	NP_572358.1	7tm_classA_rhodopsin-like	53..325	CDD:410626	83/307 (27%)
		TM helix 1	53..78	CDD:410626	7/24 (29%)
		TM helix 2	86..111	CDD:410626	11/25 (44%)
		TM helix 3	123..153	CDD:410626	16/35 (46%)
		TM helix 4	166..185	CDD:410626	6/18 (33%)
		TM helix 5	204..229	CDD:410626	6/29 (21%)
		TM helix 6	261..291	CDD:410626	8/29 (28%)
		TM helix 7	300..325	CDD:410626	7/24 (29%)
Adora2b	NP_058857.2	7tm_GPCRs	8..301	CDD:475119	87/315 (28%)
		TM helix 1	10..34	CDD:410628	7/23 (30%)
		TM helix 2	43..65	CDD:410628	11/21 (52%)
		TM helix 3	79..101	CDD:410628	9/27 (33%)
		TM helix 4	124..140	CDD:410628	5/15 (33%)
		TM helix 5	180..203	CDD:410628	5/26 (19%)
		TM helix 6	233..255	CDD:410628	8/21 (38%)
		TM helix 7	269..294	CDD:410628	7/24 (29%)