DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mAChR-C and GPR21

DIOPT Version :9

Sequence 1:	NP_572358.1	Gene:	mAChR-C / 31626	FlyBaseID:	FBgn0029909	Length:	371	Species:	Drosophila melanogaster
Sequence 2:	NP_005285.1	Gene:	GPR21 / 2844	HGNCID:	4476	Length:	349	Species:	Homo sapiens

Alignment Length:	347	Identity:	86/347 - (24%)
Similarity:	137/347 - (39%)	Gaps:	74/347 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 LLWLAINAFLFVLILGGNILTIVAVRTCRHLRSVISNLFILSLAVSDFCVG-------LALPYHL 108
            ||.:.|..||.|||:.|||:.|........|....::.||.::|.:|..||       |:|.:|.
Human    29 LLEVLIIVFLTVLIISGNIIVIFVFHCAPLLNHHTTSYFIQTMAYADLFVGVSCVVPSLSLLHHP 93

  Fly   109 VFYMGSDIGAMRGP------CLLRFFLLICACCVSMLTLISIAVDRYIAVVYALHYRRYMTRRVA 167
            :            |      |.:..|::.....|||.:|..|::|||||:...|.|...:|....
Human    94 L------------PVEESLTCQIFGFVVSVLKSVSMASLACISIDRYIAITKPLTYNTLVTPWRL 146

  Fly   168 YSIIIFNWCLGALVALLPVF--WNRWPDAQACEFDEVLAPGYIAGVI--------TPGFVIIWIC 222
            ...|...|....|| .||.|  |.:              |||...|.        |..:..::|.
Human   147 RLCIFLIWLYSTLV-FLPSFFHWGK--------------PGYHGDVFQWCAESWHTDSYFTLFIV 196

  Fly   223 MFL----------VYWRIMREASKQALRLRQSVVYNTDEATTMRNLLLHPDWKSVQIVVFIMGCF 277
            |.|          .|:.|.|...:....:.:.....:.::.....:...||.:...::..|...|
Human   197 MMLYAPAALIVCFTYFNIFRICQQHTKDISERQARFSSQSGETGEVQACPDKRYAMVLFRITSVF 261

  Fly   278 TLCWLPYFCVAIAQLFSICQSSS------MIYKTTFSLAIANSALNPIIYSWKNSGFRRAFVQTL 336
            .:.||||.      ::.:.:||:      ..:.||: |||:||..|.:|||..||.|:|. ::.|
Human   262 YILWLPYI------IYFLLESSTGHSNRFASFLTTW-LAISNSFCNCVIYSLSNSVFQRG-LKRL 318

  Fly   337 CCRTARQCEDQLPADSKHRMEA 358
            .......|..|..|:..:.:.:
Human   319 SGAMCTSCASQTTANDPYTVRS 340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-C	NP_572358.1	7tm_4	61..332	CDD:304433	77/309 (25%)
mAChR-C	NP_572358.1	7tm_1	67..321	CDD:278431	67/292 (23%)
GPR21	NP_005285.1	7tm_classA_rhodopsin-like	31..308	CDD:320086	76/310 (25%)
		TM helix 1	31..56	CDD:320086	10/24 (42%)
		TM helix 2	64..90	CDD:320086	7/25 (28%)
		TM helix 3	102..132	CDD:320086	12/29 (41%)
		TM helix 4	145..164	CDD:320086	5/19 (26%)
		TM helix 5	188..213	CDD:320086	4/24 (17%)
		TM helix 6	238..275	CDD:320086	8/42 (19%)
		TM helix 7	283..308	CDD:320086	11/25 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24249
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010