DRSC/TRiP Functional Genomics Resources

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Protein Alignment mAChR-C and GPR12

DIOPT Version :9

Sequence 1:NP_572358.1 Gene:mAChR-C / 31626 FlyBaseID:FBgn0029909 Length:371 Species:Drosophila melanogaster
Sequence 2:NP_005279.1 Gene:GPR12 / 2835 HGNCID:4466 Length:334 Species:Homo sapiens


Alignment Length:302 Identity:84/302 - (27%)
Similarity:137/302 - (45%) Gaps:43/302 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    54 LAINAFLFVLILGGNILT---IVAVRTCRHLRSVISNLFIL--SLAVSDFCVGLALPYHLVFYMG 113
            |.:|.:..||...|.:::   .:.|....|..|:.:.:|:|  |||::|...|:.|..:.||...
Human    42 LVVNPWDIVLCTSGTLISCENAIVVLIIFHNPSLRAPMFLLIGSLALADLLAGIGLITNFVFAYL 106

  Fly   114 SDIGAMRGPCLLRFFLLICACCVSMLTLISIAVDRYIAVVYALHYRRYMTRRVAYSIIIFNW--- 175
            ....|.:   |:...|::.:...|:.:|::|.||||:::.|||.|....|....|.:::..|   
Human   107 LQSEATK---LVTIGLIVASFSASVCSLLAITVDRYLSLYYALTYHSERTVTFTYVMLVMLWGTS 168

  Fly   176 -CLGALVALLPVF-WNRWPDAQACEFDEVLAPGYIAGVITPGFVIIWICMFLVYWRI----MREA 234
             |||    ||||. ||...|...|.....|.... |.:::..|:.::..|..:|.:|    ||.|
Human   169 ICLG----LLPVMGWNCLRDESTCSVVRPLTKNN-AAILSVSFLFMFALMLQLYIQICKIVMRHA 228

  Fly   235 SKQALRLRQSVVYNTDEATTMRNLLLHPDWKSVQIVVFIMGCFTLCWLPYFCVAIAQLFSICQS- 298
            .:.||   |.....|....|.|        |.|..:..|:|.|..||:|:      .|:|:... 
Human   229 HQIAL---QHHFLATSHYVTTR--------KGVSTLAIILGTFAACWMPF------TLYSLIADY 276

  Fly   299 --SSMIYKTTFSLAIANSALNPIIYSWKNSGFRRAFVQTLCC 338
              .|:....|...|..||.:||:||:::|...::|.. .:||
Human   277 TYPSIYTYATLLPATYNSIINPVIYAFRNQEIQKALC-LICC 317

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mAChR-CNP_572358.1 7tm_4 61..332 CDD:304433 79/287 (28%)
7tm_1 67..321 CDD:278431 74/270 (27%)
GPR12NP_005279.1 7tmA_GPR12 45..312 CDD:320627 80/291 (27%)
TM helix 1 47..71 CDD:320627 4/23 (17%)
TM helix 2 80..101 CDD:320627 8/20 (40%)
TM helix 3 114..136 CDD:320627 5/21 (24%)
TM helix 4 159..175 CDD:320627 5/19 (26%)
TM helix 5 195..218 CDD:320627 3/23 (13%)
TM helix 6 250..272 CDD:320627 8/27 (30%)
TM helix 7 280..305 CDD:320627 9/24 (38%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S7095
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.860

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