DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mAChR-C and Adora2a

DIOPT Version :9

Sequence 1:	NP_572358.1	Gene:	mAChR-C / 31626	FlyBaseID:	FBgn0029909	Length:	371	Species:	Drosophila melanogaster
Sequence 2:	NP_445746.3	Gene:	Adora2a / 25369	RGDID:	2049	Length:	410	Species:	Rattus norvegicus

Alignment Length:	348	Identity:	97/348 - (27%)
Similarity:	157/348 - (45%)	Gaps:	54/348 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 GHLLWLAINAFLFVLILGGNILTIVAVRTCRHLRSVISNLFILSLAVSDFCVG-LALPYHLVFYM 112
            |..:::.:...:.||.:.||:|...||....:|::| :|.|::|||.:|..|| ||:|:.:....
  Rat     2 GSSVYITVELAIAVLAILGNVLVCWAVWINSNLQNV-TNFFVVSLAAADIAVGVLAIPFAITIST 65

  Fly   113 GSDIGAMRGPCLLRFFLLICACCVSMLT------LISIAVDRYIAVVYALHYRRYMTRRVAYSII 171
            |. ..|..| ||  ||    ||.|.:||      |::||:|||||:...|.|...:|...|..||
  Rat    66 GF-CAACHG-CL--FF----ACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGVRAKGII 122

  Fly   172 IFNWCLGALVALLPVF-WNRWPDAQ------------ACEFDEVLAPGYIAGVITPGFVII-WIC 222
            ...|.|...:.|.|:. ||......            .|.|::|:...|:.......||:: .:.
  Rat   123 AICWVLSFAIGLTPMLGWNNCSQKDGNSTKTCGEGRVTCLFEDVVPMNYMVYYNFFAFVLLPLLL 187

  Fly   223 MFLVYWRIMREASKQALRLRQSVVYNTDEATTMRNLLLHPDWKSVQIVVFIMGCFTLCWLP---- 283
            |..:|.||...|.:|..::....:......:|     |..:..:.:.:..|:|.|.|||||
  Rat   188 MLAIYLRIFLAARRQLKQMESQPLPGERTRST-----LQKEVHAAKSLAIIVGLFALCWLPLHII 247

  Fly   284 ----YFCVAIAQLFSICQSSS--MIYKTTFSLAIANSALNPIIYSWKNSGFRRAFVQTLCCRTAR 342
                :||       |.|:.:.  ::| ....|:.:||.:||.||:::...||:.|.:.:.....|
  Rat   248 NCFTFFC-------STCRHAPPWLMY-LAIILSHSNSVVNPFIYAYRIREFRQTFRKIIRTHVLR 304

  Fly   343 QCED-QLPADSKHRMEATSSSQE 364
            :.|. |....|...:.|.|:..|
  Rat   305 RQEPFQAGGSSAWALAAHSTEGE 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-C	NP_572358.1	7tm_4	61..332	CDD:304433	88/301 (29%)
mAChR-C	NP_572358.1	7tm_1	67..321	CDD:278431	82/284 (29%)
Adora2a	NP_445746.3	7tmA_Adenosine_R_A2A	4..294	CDD:320196	88/311 (28%)
		TM helix 1	6..30	CDD:320196	7/23 (30%)
		TM helix 2	39..61	CDD:320196	11/21 (52%)
		TM helix 3	75..97	CDD:320196	10/27 (37%)
		TM helix 4	120..136	CDD:320196	5/15 (33%)
		Agonist binding. /evidence=ECO:0000250	163..172		2/8 (25%)
		TM helix 5	170..193	CDD:320196	4/22 (18%)
		TM helix 6	227..249	CDD:320196	8/21 (38%)
		Agonist binding. /evidence=ECO:0000250	241..248		3/6 (50%)
		Agonist binding. /evidence=ECO:0000250	259..269		1/10 (10%)
		TM helix 7	262..287	CDD:320196	8/25 (32%)
		Interaction with GAS2L2. /evidence=ECO:0000269\|PubMed:23994616	322..410		2/6 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	344..410
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D252862at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920