DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mAChR-C and Adrb1

DIOPT Version :9

Sequence 1:	NP_572358.1	Gene:	mAChR-C / 31626	FlyBaseID:	FBgn0029909	Length:	371	Species:	Drosophila melanogaster
Sequence 2:	NP_036833.1	Gene:	Adrb1 / 24925	RGDID:	2059	Length:	466	Species:	Rattus norvegicus

Alignment Length:	394	Identity:	112/394 - (28%)
Similarity:	173/394 - (43%)	Gaps:	76/394 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SSSSPAWD---------YRSSPEALGVVPFLWQHQNATETPTEITLQATSFGAGHLLWLAINAFL 60
            ||::|..|         ..:||.|..:.|       |:|....::.|.|: |.|.||     |.:
  Rat    17 SSAAPLPDGAATAARLLVLASPPASLLPP-------ASEGSAPLSQQWTA-GMGLLL-----ALI 68

  Fly    61 FVLILGGNILTIVAVRTCRHLRSVISNLFILSLAVSDFCVGLALPYHLVFYMGSDI---GAMR-G 121
            .:||:.||:|.|||:.....|:: ::||||:|||.:|..:||     ||...|:.|   |... |
  Rat    69 VLLIVVGNVLVIVAIAKTPRLQT-LTNLFIMSLASADLVMGL-----LVVPFGATIVVWGRWEYG 127

  Fly   122 PCLLRFFLLICACCV--SMLTLISIAVDRYIAVVYALHYRRYMTRRVAYSIIIFNWCLGALVALL 184
            ......:..:...||  |:.||..||:|||:|:.....|:..:||..|.:::...|.:.|||:.|
  Rat   128 SFFCELWTSVDVLCVTASIETLCVIALDRYLAITLPFRYQSLLTRARARALVCTVWAISALVSFL 192

  Fly   185 PVFWNRW-----------PDAQACEFDEVLAPGYIAGVITPGFVIIWICMFLVYWRIMREASKQA 238
            |:..:.|           .|.:.|:|....|....:.|::  |.:....|..||.|:.|||.||.
  Rat   193 PILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVS--FYVPLCIMAFVYLRVFREAQKQV 255

  Fly   239 LRL----------------------------RQSVVYNTDEATTMRNLLLHPDWKSVQIVVFIMG 275
            .::                            ..|:............|:...:.|:::.:..|||
  Rat   256 KKIDSCERRFLTGPPRPPSPAPSPSPGPPRPADSLANGRSSKRRPSRLVALREQKALKTLGIIMG 320

  Fly   276 CFTLCWLPYFCVAIAQLFSICQSSSMIYKTTFSLAIANSALNPIIYSWKNSGFRRAFVQTLCCRT 340
            .|||||||:|...:.:.|........::.....|..||||.|||||. ::..||:||.:.|||..
  Rat   321 VFTLCWLPFFLANVVKAFHRDLVPDRLFVFFNWLGYANSAFNPIIYC-RSPDFRKAFQRLLCCAR 384

  Fly   341 ARQC 344
            ...|
  Rat   385 RAAC 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-C	NP_572358.1	7tm_4	61..332	CDD:304433	89/315 (28%)
mAChR-C	NP_572358.1	7tm_1	67..321	CDD:278431	83/298 (28%)
Adrb1	NP_036833.1	7tm_1	75..366	CDD:278431	83/298 (28%)
		7tm_4	76..>267	CDD:304433	59/198 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	264..302		1/37 (3%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..466
		PDZ-Binding. /evidence=ECO:0000250	463..466
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910