DRSC/TRiP Functional Genomics Resources

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Protein Alignment mAChR-C and Chrm3

DIOPT Version :9

Sequence 1:NP_572358.1 Gene:mAChR-C / 31626 FlyBaseID:FBgn0029909 Length:371 Species:Drosophila melanogaster
Sequence 2:NP_036659.2 Gene:Chrm3 / 24260 RGDID:2343 Length:589 Species:Rattus norvegicus


Alignment Length:589 Identity:109/589 - (18%)
Similarity:173/589 - (29%) Gaps:245/589 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 SSSSP-------AWDYRSSPEA---LGVVPFLWQHQNATETPTEITLQATS--FGAGHLLWLAI- 56
            |::||       :| ..|..||   ||.|..|..:..:.||....:...:|  .| ||.:|..: 
  Rat     7 STTSPLFPNISSSW-VHSPSEAGLPLGTVTQLGSYNISQETGNFSSNDTSSDPLG-GHTIWQVVF 69

  Fly    57 ----NAFLFVLILGGNILTIVAVRTCRHLRSVISNLFILSLAVSDFCVGLALPYHLVFYMGSDIG 117
                ..||.::.:.||||.|||.:..:.|::| :|.|:||||.:|..:|:........|:..:..
  Rat    70 IAFLTGFLALVTIIGNILVIVAFKVNKQLKTV-NNYFLLSLACADLIIGVISMNLFTTYIIMNRW 133

  Fly   118 AMRG-PCLLRFFLLICACCVSMLTLISIAVDRYIAVVYALHYRRYMTRRVAYSIIIFNWCLG-AL 180
            |:.. .|.|...:...|...|::.|:.|:.|||.::...|.||...|.:.|..:|...|.:. .|
  Rat   134 ALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVL 198

  Fly   181 VALLPVFWNRW------PDAQACEFDEVLAPGYIAGVITPGFVIIWICMFLVYWRIMREASKQ-- 237
            .|...:||..:      |..: |....:..|....|.....|.:....|.::||||.:|..|:  
  Rat   199 WAPAILFWQYFVGKRTVPPGE-CFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTK 262

  Fly   238 ----------------------------ALRLRQSVV---------------------------- 246
                                        :..|:|..|                            
  Rat   263 ELAGLQASGTEAEAENFVHPTGSSRSCSSYELQQQGVKRSSRRKYGRCHFWFTTKSWKPSAEQMD 327

  Fly   247 ---------YNTDEATTMRN--------------------------------------------- 257
                     .|.|.|.::.|                                             
  Rat   328 QDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSSILNSTKLPSSDNLQVSN 392

  Fly   258 ----------------------------------------------------------------- 257
                                                                             
  Rat   393 EDLGTVDVERNAHKLQAQKSMGDGDNCQKDFTKLPIQLESAVDTGKTSDTNSSADKTTATLPLSF 457

  Fly   258 ----------------------LLLHPDWKSVQIVVFIMGCFTLCWLPYFCVAIAQLFSICQSSS 300
                                  :.|..:.|:.|.:..|:..|.:.|.||..:.:...|  |  .|
  Rat   458 KEATLAKRFALKTRSQITKRKRMSLIKEKKAAQTLSAILLAFIITWTPYNIMVLVNTF--C--DS 518

  Fly   301 MIYKTTFS----LAIANSALNPIIYSWKNSGFRRAFVQTLCCRTARQCEDQLPADSKHRMEATSS 361
            .|.||.::    |...||.:||:.|:..|..||..|...|.|    ||:.:     |.|.:....
  Rat   519 CIPKTYWNLGYWLCYINSTVNPVCYALCNKTFRTTFKTLLLC----QCDKR-----KRRKQQYQQ 574

  Fly   362 SQEI 365
            .|.:
  Rat   575 RQSV 578

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mAChR-CNP_572358.1 7tm_4 61..332 CDD:304433 81/481 (17%)
7tm_1 67..321 CDD:278431 77/464 (17%)
Chrm3NP_036659.2 7tmA_mAChR_M3 65..>269 CDD:320426 54/205 (26%)
TM helix 1 70..94 CDD:320426 9/23 (39%)
TM helix 2 103..125 CDD:320426 8/21 (38%)
TM helix 3 141..163 CDD:320426 5/21 (24%)
Agonist binding. /evidence=ECO:0000305 147..151 0/3 (0%)
TM helix 4 186..202 CDD:320426 4/15 (27%)
TM helix 5 228..251 CDD:320426 4/22 (18%)
Basolateral sorting signal. /evidence=ECO:0000250 274..280 0/5 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 323..356 4/32 (13%)
7tm_GPCRs <483..563 CDD:421689 26/87 (30%)
TM helix 6 486..513 CDD:410628 7/26 (27%)
Agonist binding. /evidence=ECO:0000305 506..529 7/26 (27%)
TM helix 7 522..547 CDD:410628 8/24 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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