DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mAChR-C and F57C9.6

DIOPT Version :9

Sequence 1:	NP_572358.1	Gene:	mAChR-C / 31626	FlyBaseID:	FBgn0029909	Length:	371	Species:	Drosophila melanogaster
Sequence 2:	NP_491456.2	Gene:	F57C9.6 / 186448	WormBaseID:	WBGene00019012	Length:	389	Species:	Caenorhabditis elegans

Alignment Length:	370	Identity:	79/370 - (21%)
Similarity:	150/370 - (40%)	Gaps:	90/370 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 GVVPFLWQHQNATETPTEITLQATSFGAGH----LLWLAINAFLFVLILGGNILTIVAVRTCRHL 81
            ||||       ||| ..|.:.....||..:    :|.:.:|..:|..|       |:..||   .
Worm    29 GVVP-------ATE-EMEWSTVGGRFGMAYIAFGILAILVNIVIFACI-------IIRRRT---T 75

  Fly    82 RSVISNLFILSLAVSDFCVGL-----ALPYHLVFYMGSDIGAM-------RGPCLLRFFLLICAC 134
            .|.:..:.||:..:.|...|:     ||.. |.|.|.:| |:|       ....||||..|
Worm    76 SSHVFYIIILNFTIIDTIKGICSVLFALKL-LTFNMATD-GSMWTVRVDQYSGVLLRFTNL---- 134

  Fly   135 CVSMLTLISIAVDRYIAVVYALHYRRYMTR-RVAYSIIIFNWCLGALVALLPVFWNR-----WPD 193
             .:::.::.|.::.:|.:.:.|.|...:|| ||.::|:: :|.|..::.:|.:..:.     ..|
Worm   135 -TTIMNVLLITMNEFIFICHPLRYSSIVTRCRVLWAIVL-SWLLAFVLTVLNMLTSTRQRSVMID 197

  Fly   194 AQACEFDEV-------------LAPGYIAGVITPGFVIIWI-----CMFLVYWRIMREASKQALR 240
            .: ||.:.:             |:..::..:|...|.:|.:     |.|::: ||:.:.
Worm   198 TE-CENEMMSGASFCIKHQETSLSHYFVFHMILIAFCLICLAITASCYFILF-RIITKL------ 254

  Fly   241 LRQSVVYNTDEATTMRNLLLHPDWKSV---QIVVFIMGCFTLCWLPYFCVAIAQLFSICQSSSMI 302
            :|..|.|..:......:   |...||:   :..|.::|...|.:..|...     :::.|...::
Worm   255 VRADVKYQAETDLLKED---HSHGKSIARRKKYVLMIGSVILVYSVYLTT-----YAVIQGMHLV 311

  Fly   303 YKTTFSLAIANSALNPIIYSWKNSGFR----RAFVQTLCCRTARQ 343
            ..|:.|..|...|.:..|:: |.:.:.    .:.:|.||....|:
Worm   312 NITSRSKGIPVHARSGYIFT-KYTCYLFISFHSLLQPLCFMRMRE 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-C	NP_572358.1	7tm_4	61..332	CDD:304433	63/313 (20%)
mAChR-C	NP_572358.1	7tm_1	67..321	CDD:278431	59/292 (20%)
F57C9.6	NP_491456.2	7tm_classA_rhodopsin-like	49..305	CDD:381740	58/289 (20%)
		TM helix 1	49..72	CDD:381740	5/29 (17%)
		TM helix 2	81..103	CDD:381740	4/21 (19%)
		TM helix 3	123..145	CDD:381740	6/26 (23%)
		TM helix 4	168..184	CDD:381740	3/16 (19%)
		TM helix 5	222..245	CDD:381740	4/22 (18%)
		TM helix 6	282..305	CDD:381740	4/27 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910