DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mAChR-C and C01F1.4

DIOPT Version :9

Sequence 1:	NP_572358.1	Gene:	mAChR-C / 31626	FlyBaseID:	FBgn0029909	Length:	371	Species:	Drosophila melanogaster
Sequence 2:	NP_494751.1	Gene:	C01F1.4 / 182068	WormBaseID:	WBGene00015299	Length:	333	Species:	Caenorhabditis elegans

Alignment Length:	351	Identity:	68/351 - (19%)
Similarity:	129/351 - (36%)	Gaps:	76/351 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 LLWLAINAFLFVLILGGNILTIVAVRTCRHLRSVISNLFILSLAVSD----FCVGLALPY----- 106
            ::...:.|||       |.:.:::...|: :||....| ..|||:||    ..:|.:|.:
Worm    18 IILCCVAAFL-------NFMVVISRLYCK-MRSASLEL-TYSLALSDTWTSIVIGFSLFWNSYKP 73

  Fly   107 ------HLVFYMGSDIGAMRGPCLLRFFLLICACCVSMLTLISIAVDRYIAVVYALHYRRYMTRR 165
                  |..:.....:.|.|...||          ..:..|:::|...|:.:.....:.:.:..|
Worm    74 VVLNIPHSSYCFPLTLEAFRTGGLL----------TGIFHLVALAFTHYMTIKRPFDHHKVLPIR 128

  Fly   166 VAYSIIIFNWCLGALVALLPVFWNRWPDAQA--CEFDEVLAPGYIAGVITPGFVIIWICMFLVYW 228
            ..|.:|.|.|....:..::....|.....|:  |...:.....|...:::...|.:.|...:.|.
Worm   129 TIYIMIFFMWATPPMALMIYFASNSGQGYQSEKCMGIKFYENFYFRALVSLIIVFLIILTTIFYI 193

  Fly   229 RIMREASKQALRLRQSVVYNTDE-ATTMRNLLLHPDWKSVQIVVFIMGCFTLCWLPYFCVAIAQL 292
            :::::.::    :|.....|:.. ..:.|..      ::|...|.|.|.|.:.|:|      |.:
Worm   194 KMLQKITE----VRSKTASNSQTLGASARGR------RTVVTAVLIFGTFLIGWMP------ASI 242

  Fly   293 FSICQSSSM-IYK------TTFSLAI-----ANSALNPIIYSWKNSGFRRAFVQTLCCRTARQCE 345
            ..|..:.|| :|.      |..|:|:     |.:..|||||:.:.....:...|.|..|.
Worm   243 LYILTAESMPLYNKHSVSITIMSIAVLVSIMAKTLCNPIIYATRIPEINQFVFQKLLYRV----- 302

  Fly   346 DQLPADSKHRMEATSSSQEIKPKATQ 371
              ||.    |........|::|..|:
Worm   303 --LPG----RNPTIRRQSELEPLKTR 322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-C	NP_572358.1	7tm_4	61..332	CDD:304433	56/300 (19%)
mAChR-C	NP_572358.1	7tm_1	67..321	CDD:278431	54/283 (19%)
C01F1.4	NP_494751.1	7tm_classA_rhodopsin-like	17..286	CDD:381740	59/302 (20%)
		TM helix 1	17..37	CDD:381740	4/25 (16%)
		TM helix 2	45..69	CDD:381740	8/24 (33%)
		TM helix 3	85..109	CDD:381740	5/33 (15%)
		TM helix 4	132..148	CDD:381740	3/15 (20%)
		TM helix 5	174..193	CDD:381740	2/18 (11%)
		TM helix 6	220..245	CDD:381740	8/36 (22%)
		TM helix 7	261..286	CDD:381740	9/24 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7095
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950