Protein Alignment mAChR-C and DRD3

DIOPT Version :10

• Sequence 1: NP_572358.1
• Gene: mAChR-C / 31626
• FlyBaseID: FBgn0029909
• Length: 371
• Species: Drosophila melanogaster
• Sequence 2: NP_000787.2
• Gene: DRD3 / 1814
• HGNCID: 3024
• Length: 400
• Species: Homo sapiens
• Alignment Length: 390
• Identity: 100/390 - (25%)
• Similarity: 152/390 - (38%)
• Gaps: 105/390 - (26%)

  Fly    45 SFGAG----HLLWLAINAFLFVLILGGNILTIVAVRTCRHLRSVISNLFILSLAVSDFCVG-LAL 104
            |.||.    |..:......|.:.|:.||.|..:||...|.|::. :|..::||||:|..|. |.:
Human    20 STGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTT-TNYLVVSLAVADLLVATLVM 83

  Fly   105 PYHLVFYM---GSDIGAMRGPCLLRFFLLICACCVSMLTLISIAVDRYIAVVYALHYR----RYM 162
            |:  |.|:   |......|..|.:...|.:..|..|:|.|.:|::|||.|||..:||:    :..
Human    84 PW--VVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSS 146

  Fly   163 TRRVAYSIIIFNWCLGALVALLPVF-WNRWPDAQACEFDEVLAPGYIAGVITPGFVIIWICMFLV 226
            .||||..|... |.|...|:...:| :|...|...|....   |.::.......|.:.:....||
Human   147 CRRVALMITAV-WVLAFAVSCPLLFGFNTTGDPTVCSISN---PDFVIYSSVVSFYLPFGVTVLV 207

  Fly   227 YWRI---MREASKQALRLRQSVVYNT--------------------------------------- 249
            |.||   :::..::.:..||:...|:
Human   208 YARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQER 272

  Fly   250 ------DEATTMRNLL----------------------------LHP------DWKSVQIVVFIM 274
                  :|.|  ||.|                            |.|      :.|:.|:|..::
Human   273 GGELKREEKT--RNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVL 335

  Fly   275 GCFTLCWLPYFCVAIAQLF-SICQSSSMIYKTTFSLAIANSALNPIIYSWKNSGFRRAFVQTLCC 338
            |.|.:||||:|...:.... ..|..|..:|..|..|...||||||:||:..|..||:||::.|.|
Human   336 GAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC 400

  Fly   339  338
            Human   401  400

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-C	NP_572358.1	7tm_classA_rhodopsin-like	53..325	CDD:410626	89/363 (25%)
		TM helix 1	53..78	CDD:410626	7/24 (29%)
		TM helix 2	86..111	CDD:410626	10/25 (40%)
		TM helix 3	123..153	CDD:410626	11/29 (38%)
		TM helix 4	166..185	CDD:410626	6/18 (33%)
		TM helix 5	204..229	CDD:410626	5/24 (21%)
		TM helix 6	261..291	CDD:410626	11/35 (31%)
		TM helix 7	300..325	CDD:410626	11/24 (46%)
DRD3	NP_000787.2	7tmA_D3_dopamine_R	30..394	CDD:320436	92/372 (25%)
		TM helix 1	31..57	CDD:320436	7/25 (28%)
		TM helix 2	64..87	CDD:320436	9/24 (38%)
		TM helix 3	103..133	CDD:320436	11/29 (38%)
		TM helix 4	150..168	CDD:320436	6/18 (33%)
		TM helix 5	185..210	CDD:320436	5/27 (19%)
		TM helix 6	322..352	CDD:320436	10/29 (34%)
		TM helix 7	362..387	CDD:320436	11/24 (46%)