Protein Alignment mAChR-C and DRD2

DIOPT Version :10

• Sequence 1: NP_572358.1
• Gene: mAChR-C / 31626
• FlyBaseID: FBgn0029909
• Length: 371
• Species: Drosophila melanogaster
• Sequence 2: NP_000786.1
• Gene: DRD2 / 1813
• HGNCID: 3023
• Length: 443
• Species: Homo sapiens
• Alignment Length: 405
• Identity: 88/405 - (21%)
• Similarity: 146/405 - (36%)
• Gaps: 131/405 - (32%)

  Fly    60 LFVLILGGNILTIVAVRTCRHLRSVISNLFILSLAVSDFCVG-LALPYHLVFYMGSDIGAMRGPC 123
            |..:|:.||:|..:||...:.|::. :|..|:||||:|..|. |.:|:.:...:..:....|..|
Human    44 LIAVIVFGNVLVCMAVSREKALQTT-TNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHC 107

  Fly   124 LLRFFLLICACCVSMLTLISIAVDRYIAVVYALHYR-RYMTRRVAYSIIIFNWCLGALVALLPVF 187
            .:...|.:..|..|:|.|.:|::|||.||...:.|. ||.::|....:|...|.|...::...:|
Human   108 DIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLF 172

  Fly   188 WNRWPDAQACEFDEVLA-PGYIAGVITPGFVIIWICMFLVYWR---------------------- 229
            .....|...|    ::| |.::.......|.:.:|...|||.:
Human   173 GLNNADQNEC----IIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFR 233

  Fly   230 ----------------------IMR------------EASKQALRLRQSVVYNTD---------- 250
                                  ||:            ||:::|..|...::.:|.
Human   234 AHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPI 298

  Fly   251 -------------------------------------------EATTM--------------RNL 258
                                                       |..||              |.|
Human   299 PPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKL 363

  Fly   259 LLHPDWKSVQIVVFIMGCFTLCWLPYFCVAIAQLFSICQSSSMIYKTTFSLAIANSALNPIIYSW 323
            ....:.|:.|::..::|.|.:||||:|...|..:...|....::|.....|...|||:|||||:.
Human   364 SQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTT 428

  Fly   324 KNSGFRRAFVQTLCC 338
            .|..||:||::.|.|
Human   429 FNIEFRKAFLKILHC 443

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-C	NP_572358.1	7tm_classA_rhodopsin-like	53..325	CDD:410626	81/390 (21%)
		TM helix 1	53..78	CDD:410626	7/17 (41%)
		TM helix 2	86..111	CDD:410626	10/25 (40%)
		TM helix 3	123..153	CDD:410626	11/29 (38%)
		TM helix 4	166..185	CDD:410626	3/18 (17%)
		TM helix 5	204..229	CDD:410626	7/25 (28%)
		TM helix 6	261..291	CDD:410626	10/29 (34%)
		TM helix 7	300..325	CDD:410626	10/24 (42%)
DRD2	NP_000786.1	7tmA_D2_dopamine_R	35..437	CDD:320435	84/397 (21%)
		TM helix 1	36..62	CDD:320435	7/17 (41%)
		TM helix 2	69..92	CDD:320435	10/22 (45%)
		TM helix 3	107..137	CDD:320435	11/29 (38%)
		TM helix 4	152..170	CDD:320435	3/17 (18%)
		TM helix 5	186..211	CDD:320435	6/24 (25%)
		Interaction with PPP1R9B. /evidence=ECO:0000250	211..373		13/161 (8%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	281..332		1/50 (2%)
		TM helix 6	366..396	CDD:320435	10/29 (34%)
		TM helix 7	405..430	CDD:320435	10/24 (42%)