DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mAChR-C and F36D4.4

DIOPT Version :9

Sequence 1:	NP_572358.1	Gene:	mAChR-C / 31626	FlyBaseID:	FBgn0029909	Length:	371	Species:	Drosophila melanogaster
Sequence 2:	NP_001343846.1	Gene:	F36D4.4 / 179322	WormBaseID:	WBGene00018089	Length:	523	Species:	Caenorhabditis elegans

Alignment Length:	378	Identity:	94/378 - (24%)
Similarity:	151/378 - (39%)	Gaps:	94/378 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 VPFLWQHQNATETPTEITLQATSFGAGHL--LWLAINAFLFVLILGGNILTIVAVRTCRHLRSVI 85
            |||...:...|...|.:      |..|||  |.:.:|.|:.:.:|             ||.|.|:
Worm    59 VPFYENYSQETMATTAV------FLCGHLGALSVILNLFVIIALL-------------RHRRRVL 104

  Fly    86 SNLF---ILSLAVSDFCVGLAL-PYHLVFYMGS------DIGA-MRGPCLLRFFLLICACCVSML 139
            ||:|   :|..||.|...|:.| .|.|.::..|      ||.. :....|.||.|:|...| ::|
Worm   105 SNVFYVIVLHCAVLDVARGVCLILYGLPYFANSFYNINLDIHTRIHLFQLSRFALVILRVC-NLL 168

  Fly   140 TLISIAV---DRYIAVVYALHYRRYMTRRVAYSIIIFNWCLGALVALLPVF-----WNRW--PDA 194
            |:.::.|   :.||.:.|.||||||..|:....|:...|.:..::||..::     ...|  |:.
Worm   169 TIFNLLVFTTNEYIVIRYPLHYRRYFRRKFVLIILAICWTMSIMMALGILYSSSKSQTEWLPPEE 233

  Fly   195 QACEFDEVLAPGYIAGV--ITPGFVIIWICMFLVYWRIMREASKQALRLRQSVVYNTDEATTMRN 257
            :..:| ..:....|:.:  :|.|.|:  ||    |..|:|...|    .:.....|.||:..:.|
Worm   234 RGIDF-ATITMVLISSLCFVTLGTVV--IC----YISILRTIRK----FKDEGCLNNDESHRIHN 287

  Fly   258 LLLH------------------PDWKSVQIV-----VFIMGCFTLCWLPYFC----------VAI 289
            ..||                  ..|:|||.:     ::::|...:..|.:.|          :.|
Worm   288 RSLHRPINGQGSNCSNGSSLRGSKWRSVQAMSRHKYIYVIGSVLIVDLLFLCPYSGIQMVSFLHI 352

  Fly   290 AQLFSICQSSSMIYKTTFSLAIANSALNPIIYSWKNSGFRRAFVQTLCCRTAR 342
            .....|...|::|......|...:|...|:.| ::.:.|||    ..||...|
Worm   353 NNFLQITHGSTLIRWWLQVLIGVHSVCQPLCY-FRMTEFRR----LACCNPRR 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-C	NP_572358.1	7tm_4	61..332	CDD:304433	79/326 (24%)
mAChR-C	NP_572358.1	7tm_1	67..321	CDD:278431	74/309 (24%)
F36D4.4	NP_001343846.1	7tm_classA_rhodopsin-like	81..387	CDD:381740	80/331 (24%)
		TM helix 2	109..131	CDD:381740	7/21 (33%)
		TM helix 3	156..178	CDD:381740	8/22 (36%)
		TM helix 4	201..215	CDD:381740	2/13 (15%)
		TM helix 5	239..262	CDD:381740	6/28 (21%)
		TM helix 6	321..346	CDD:381740	3/24 (13%)
		TM helix 7	359..387	CDD:381740	6/28 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910