DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mAChR-C and ADRB3

DIOPT Version :9

Sequence 1:	NP_572358.1	Gene:	mAChR-C / 31626	FlyBaseID:	FBgn0029909	Length:	371	Species:	Drosophila melanogaster
Sequence 2:	NP_000016.1	Gene:	ADRB3 / 155	HGNCID:	288	Length:	408	Species:	Homo sapiens

Alignment Length:	387	Identity:	107/387 - (27%)
Similarity:	174/387 - (44%)	Gaps:	82/387 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 WQHQNAT-----ETPTEITLQATSFG----------AGHLLWLAINAFLFVLILGGNILTIVAVR 76
            |.|:|::     :.||.....|.:.|          ||.||.||:.|     .:|||:|.|||:.
Human     4 WPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLA-----TVGGNLLVIVAIA 63

  Fly    77 TCRHLRSVISNLFILSLAVSDFCVGLAL--PYHLVFYMGS-DIGAMRGPCLLRFFLLICACCVSM 138
            ....|:: ::|:|:.|||.:|..:||.:  |...:...|. .:||.  .|.|...:.:.....|:
Human    64 WTPRLQT-MTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGAT--GCELWTSVDVLCVTASI 125

  Fly   139 LTLISIAVDRYIAVVYALHYRRYMTRRVAYSIIIFNWCLGALVALLPV---FWNRWPDAQA---- 196
            .||.::|||||:||...|.|...:|:|.|.:.::..|.:.|.|:..|:   :|....||:|
Human   126 ETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCH 190

  Fly   197 -----CEFDEVLAPGYIAGVITPGFVIIWICMFLVYWRIMREASKQALRLRQSVV--YNTDEATT 254
                 |.|...:.  |:....:..|.:..:.|..||.|:...|::| |||.:..:  :..:|:..
Human   191 SNPRCCAFASNMP--YVLLSSSVSFYLPLLVMLFVYARVFVVATRQ-LRLLRGELGRFPPEESPP 252

  Fly   255 MRNLLLHP--------------------------DWKSVQIVVFIMGCFTLCWLPYFCVAIAQLF 293
            ..:..|.|                          :.:::..:..|||.|||||||:|   :|.:.
Human   253 APSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFF---LANVL 314

  Fly   294 SICQSSSMIYKTTFS----LAIANSALNPIIYSWKNSGFRRAFVQTLCCRTARQCEDQLPAD 351
            ......|::....|.    |..||||.||:||. ::..||.||.:.||     :|..:||.:
Human   315 RALGGPSLVPGPAFLALNWLGYANSAFNPLIYC-RSPDFRSAFRRLLC-----RCGRRLPPE 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-C	NP_572358.1	7tm_4	61..332	CDD:304433	86/317 (27%)
mAChR-C	NP_572358.1	7tm_1	67..321	CDD:278431	81/300 (27%)
ADRB3	NP_000016.1	7tm_GPCRs	51..356	CDD:333717	86/314 (27%)
		TM helix 2	73..95	CDD:320095	9/21 (43%)
		TM helix 3	111..133	CDD:320095	4/21 (19%)
		TM helix 4	156..172	CDD:320095	3/15 (20%)
		TM helix 5	202..225	CDD:320095	4/24 (17%)
		TM helix 6	288..313	CDD:320095	12/27 (44%)
		TM helix 7	325..350	CDD:320095	10/25 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910