DRSC/TRiP Functional Genomics Resources

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Protein Alignment mAChR-C and Hrh1

DIOPT Version :9

Sequence 1:NP_572358.1 Gene:mAChR-C / 31626 FlyBaseID:FBgn0029909 Length:371 Species:Drosophila melanogaster
Sequence 2:NP_001239571.1 Gene:Hrh1 / 15465 MGIID:107619 Length:488 Species:Mus musculus


Alignment Length:474 Identity:94/474 - (19%)
Similarity:159/474 - (33%) Gaps:182/474 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    44 TSFGAGHLLWL-AINAFLFVLILGGNILTIVAVRTCRHLRSVISNLFILSLAVSDFCVG-LALPY 106
            |:..:..||.| .:.:.:.::.:|.|:|.:.|||:.|.|.:| .||:|:||:|:|..|| :.:|.
Mouse    20 TAMASPQLLPLVVVLSSISLVTVGLNLLVLYAVRSERKLHTV-GNLYIVSLSVADLIVGAVVMPM 83

  Fly   107 HLVFYMGSDIGAMRGPCLLRFFLLICACCVSMLTLISIAVDRYIAVVYALHYRRYMTRRVAYSII 171
            ::::.:.:.....|..||....:...|...|:.::..:.:|||.:|...|.|.||.|:..|.:.|
Mouse    84 NILYLIMTKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATI 148

  Fly   172 IFNWCLGALVALLPVFWNRW----PDAQ--ACEFD-------EVLAPGYIAGVITPGFVIIWI-- 221
            :..|.|..|..:..:.|:.:    |:.:  .||.|       :::..  |.....|..:::|.  
Mouse   149 LGAWFLSFLWVIPILGWHHFTPLAPELREDKCETDFYNVTWFKIMTA--IINFYLPTLLMLWFYV 211

  Fly   222 ---------CM-----------FLVY-------------------WRIMREASK----------- 236
                     |.           ||..                   |.:.:..|:           
Mouse   212 KIYKAVRRHCQHRQLTNGSLPTFLEIKLRSEDAKEGAKKPGKESPWGVQKRPSRDPTGGLDQKST 276

  Fly   237 ----------------------------------------------------------------- 236
                                                                             
Mouse   277 SEDPKVTSPTVFSQEGERETVTRPCFRLDVMQTQPVPEGDARGSKANDQTLSQPKMDEQSLSTCR 341

  Fly   237 --------QALRLRQSVVYNTDEATTMR-----------------------------------NL 258
                    |.|..|||....||..|::.                                   .|
Mouse   342 RISETSEDQTLVDRQSFSRTTDSDTSIEPGLGKVKARSRSNSGLDYIKVTWKRLRSHSRQYVSGL 406

  Fly   259 LLHPDWKSVQIVVFIMGCFTLCWLPYFC--VAIAQLFSICQSSSMIYKTTFSLAIANSALNPIIY 321
            .|:.:.|:.:.:..||..|.|||:|||.  :.||...|.|  |..::..|..|...||.|||:||
Mouse   407 HLNRERKAAKQLGCIMAAFILCWIPYFIFFMVIAFCNSCC--SEPVHMFTIWLGYINSTLNPLIY 469

  Fly   322 SWKNSGFRRAFVQTLCCRT 340
            ...|..|::.|.:.|..|:
Mouse   470 PLCNENFKKTFKKILHIRS 488

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mAChR-CNP_572358.1 7tm_4 61..332 CDD:304433 87/446 (20%)
7tm_1 67..321 CDD:278431 82/429 (19%)
Hrh1NP_001239571.1 7tmA_Histamine_H1R 29..480 CDD:320178 88/455 (19%)
TM helix 1 29..55 CDD:320178 7/25 (28%)
TM helix 2 62..88 CDD:320178 10/25 (40%)
TM helix 3 100..130 CDD:320178 7/29 (24%)
Important for agonist binding. /evidence=ECO:0000250 107..112 1/4 (25%)
TM helix 4 142..163 CDD:320178 5/20 (25%)
TM helix 5 187..216 CDD:320178 3/30 (10%)
TM helix 6 218..439 CDD:320178 25/220 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 245..337 2/91 (2%)
Important for agonist binding. /evidence=ECO:0000250 425..429 2/3 (67%)
TM helix 7 448..473 CDD:320178 9/24 (38%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167834922
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.930

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