Protein Alignment mAChR-C and Hrh1

DIOPT Version :10

• Sequence 1: NP_572358.1
• Gene: mAChR-C / 31626
• FlyBaseID: FBgn0029909
• Length: 371
• Species: Drosophila melanogaster
• Sequence 2: NP_032311.2
• Gene: Hrh1 / 15465
• MGIID: 107619
• Length: 488
• Species: Mus musculus
• Alignment Length: 474
• Identity: 94/474 - (19%)
• Similarity: 159/474 - (33%)
• Gaps: 182/474 - (38%)

  Fly    44 TSFGAGHLLWL-AINAFLFVLILGGNILTIVAVRTCRHLRSVISNLFILSLAVSDFCVG-LALPY 106
            |:..:..||.| .:.:.:.::.:|.|:|.:.|||:.|.|.:| .||:|:||:|:|..|| :.:|.
Mouse    20 TAMASPQLLPLVVVLSSISLVTVGLNLLVLYAVRSERKLHTV-GNLYIVSLSVADLIVGAVVMPM 83

  Fly   107 HLVFYMGSDIGAMRGPCLLRFFLLICACCVSMLTLISIAVDRYIAVVYALHYRRYMTRRVAYSII 171
            ::::.:.:.....|..||....:...|...|:.::..:.:|||.:|...|.|.||.|:..|.:.|
Mouse    84 NILYLIMTKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATI 148

  Fly   172 IFNWCLGALVALLPVFWNRW----PDAQ--ACEFD-------EVLAPGYIAGVITPGFVIIWI-- 221
            :..|.|..|..:..:.|:.:    |:.:  .||.|       :::..  |.....|..:::|.
Mouse   149 LGAWFLSFLWVIPILGWHHFTPLAPELREDKCETDFYNVTWFKIMTA--IINFYLPTLLMLWFYV 211

  Fly   222 ---------CM-----------FLVY-------------------WRIMREASK----------- 236
                     |.           ||..                   |.:.:..|:
Mouse   212 KIYKAVRRHCQHRQLTNGSLPTFLEIKLRSEDAKEGAKKPGKESPWGVQKRPSRDPTGGLDQKST 276

  Fly   237 ----------------------------------------------------------------- 236
                                                                             
Mouse   277 SEDPKVTSPTVFSQEGERETVTRPCFRLDVMQTQPVPEGDARGSKANDQTLSQPKMDEQSLSTCR 341

  Fly   237 --------QALRLRQSVVYNTDEATTMR-----------------------------------NL 258
                    |.|..|||....||..|::.                                   .|
Mouse   342 RISETSEDQTLVDRQSFSRTTDSDTSIEPGLGKVKARSRSNSGLDYIKVTWKRLRSHSRQYVSGL 406

  Fly   259 LLHPDWKSVQIVVFIMGCFTLCWLPYFC--VAIAQLFSICQSSSMIYKTTFSLAIANSALNPIIY 321
            .|:.:.|:.:.:..||..|.|||:|||.  :.||...|.|  |..::..|..|...||.|||:||
Mouse   407 HLNRERKAAKQLGCIMAAFILCWIPYFIFFMVIAFCNSCC--SEPVHMFTIWLGYINSTLNPLIY 469

  Fly   322 SWKNSGFRRAFVQTLCCRT 340
            ...|..|::.|.:.|..|:
Mouse   470 PLCNENFKKTFKKILHIRS 488

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-C	NP_572358.1	7tm_classA_rhodopsin-like	53..325	CDD:410626	86/448 (19%)
		TM helix 1	53..78	CDD:410626	7/25 (28%)
		TM helix 2	86..111	CDD:410626	10/25 (40%)
		TM helix 3	123..153	CDD:410626	7/29 (24%)
		TM helix 4	166..185	CDD:410626	5/18 (28%)
		TM helix 5	204..229	CDD:410626	6/65 (9%)
		TM helix 6	261..291	CDD:410626	11/31 (35%)
		TM helix 7	300..325	CDD:410626	9/24 (38%)
Hrh1	NP_032311.2	7tmA_Histamine_H1R	29..480	CDD:320178	88/455 (19%)
		TM helix 1	29..55	CDD:320178	7/25 (28%)
		TM helix 2	62..88	CDD:320178	10/25 (40%)
		TM helix 3	100..130	CDD:320178	7/29 (24%)
		Important for agonist binding. /evidence=ECO:0000250|UniProtKB:P35367	107..112		1/4 (25%)
		TM helix 4	142..163	CDD:320178	5/20 (25%)
		TM helix 5	187..216	CDD:320178	3/30 (10%)
		TM helix 6	218..439	CDD:320178	25/220 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	245..337		2/91 (2%)
		Important for agonist binding. /evidence=ECO:0000250|UniProtKB:P35367	425..429		2/3 (67%)
		TM helix 7	448..473	CDD:320178	9/24 (38%)