DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mAChR-C and ADRB1

DIOPT Version :9

Sequence 1:	NP_572358.1	Gene:	mAChR-C / 31626	FlyBaseID:	FBgn0029909	Length:	371	Species:	Drosophila melanogaster
Sequence 2:	NP_000675.1	Gene:	ADRB1 / 153	HGNCID:	285	Length:	477	Species:	Homo sapiens

Alignment Length:	433	Identity:	121/433 - (27%)
Similarity:	185/433 - (42%)	Gaps:	104/433 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SSSSPAWD---------YRSSPEALGVVPFLWQHQNATETPTEITLQATSFGAGHLLWLAINAFL 60
            ||::|..|         ..:||.|..:.|       |:|:|..::.|.|: |.|.|:     |.:
Human    17 SSAAPLPDGAATAARLLVPASPPASLLPP-------ASESPEPLSQQWTA-GMGLLM-----ALI 68

  Fly    61 FVLILGGNILTIVAVRTCRHLRSVISNLFILSLAVSDFCVGLALPYHLVFYMGSDI---GAMR-G 121
            .:||:.||:|.|||:.....|:: ::||||:|||.:|..:||     ||...|:.|   |... |
Human    69 VLLIVAGNVLVIVAIAKTPRLQT-LTNLFIMSLASADLVMGL-----LVVPFGATIVVWGRWEYG 127

  Fly   122 PCLLRFFLLICACCV--SMLTLISIAVDRYIAVVYALHYRRYMTRRVAYSIIIFNWCLGALVALL 184
            ......:..:...||  |:.||..||:|||:|:.....|:..:||..|..::...|.:.|||:.|
Human   128 SFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTVWAISALVSFL 192

  Fly   185 PVFWNRW-----------PDAQACEFDEVLAPGYIAGVITPGFVIIWICMFLVYWRIMREASKQA 238
            |:..:.|           .|.:.|:|....|....:.|::  |.:....|..||.|:.|||.||.
Human   193 PILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVS--FYVPLCIMAFVYLRVFREAQKQV 255

  Fly   239 LRL--------------------------------RQSVVYNTDEATTMR-------NLLLHPDW 264
            .::                                |.:....|......|       .|:...:.
Human   256 KKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAPLANGRAGKRRPSRLVALREQ 320

  Fly   265 KSVQIVVFIMGCFTLCWLPYFCVAIAQLFSICQSSSMIYKTTFSLAIANSALNPIIYSWKNSGFR 329
            |:::.:..|||.|||||||:|...:.:.|........::.....|..||||.|||||. ::..||
Human   321 KALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFVFFNWLGYANSAFNPIIYC-RSPDFR 384

  Fly   330 RAFVQTLCC--RTARQCEDQLPADSKHRMEATSSSQEIKPKAT 370
            :||...|||  |.||            |..||...   :|:|:
Human   385 KAFQGLLCCARRAAR------------RRHATHGD---RPRAS 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-C	NP_572358.1	7tm_4	61..332	CDD:304433	91/326 (28%)
mAChR-C	NP_572358.1	7tm_1	67..321	CDD:278431	85/309 (28%)
ADRB1	NP_000675.1	7tm_4	67..>266	CDD:304433	62/206 (30%)
		7tm_1	75..377	CDD:278431	85/309 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	269..307		3/37 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	403..477		4/13 (31%)
		PDZ-Binding	474..477
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910