DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mAChR-C and GPR119

DIOPT Version :9

Sequence 1:	NP_572358.1	Gene:	mAChR-C / 31626	FlyBaseID:	FBgn0029909	Length:	371	Species:	Drosophila melanogaster
Sequence 2:	NP_848566.1	Gene:	GPR119 / 139760	HGNCID:	19060	Length:	335	Species:	Homo sapiens

Alignment Length:	342	Identity:	89/342 - (26%)
Similarity:	150/342 - (43%)	Gaps:	34/342 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 TSFGAGHLLWLAINAFLFVLILGGNILTIVAVRTCRHLRSVISNLFILSLAVSDFCVGLALPYHL 108
            :||..|.:|     |.|..||:..|.|..|||....|....:|..|.|:|||:|..:|:|:...|
Human     3 SSFSFGVIL-----AVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLL 62

  Fly   109 VFYMGS-DIGAMRGPCLLRFFLLICACCVSMLTLISIAVDRYIAVVYALHYRRYMTRRVAYSIII 172
            ...:.| .....:..|.||...:..:...|:||::.|..|||:|:.....|.:.|:..||.:.|.
Human    63 TDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIA 127

  Fly   173 FNWCLGALVALLPV---FWNRWPDAQACEFDEVLAPGYIAGVITPGFVIIWICMFLVYWRIMREA 234
            ..|.:..|:..||:   .:.:......|.|..|..|.::..:...||....:.....|..:::.|
Human   128 GLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIA 192

  Fly   235 SKQALRLRQSVVYNTDEATTMRNLLLHP----DWKSVQIVVFIMGCFTLCWLPYFCVAIAQLFSI 295
            |..:.::|:     .:.|..|......|    |:|:::.|..::|.|.|.|.|:....|.|:  .
Human   193 SMHSQQIRK-----MEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQV--A 250

  Fly   296 CQSSSM---IYKTTFSLAIANSALNPIIYS-WKNS----------GFRRAFVQTLCCRTARQCED 346
            ||...:   :.:..:.|.:.||.|||:||: |:..          |.::.....|...:||.|..
Human   251 CQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGP 315

  Fly   347 QLPADSKHRMEATSSSQ 363
            :.|.:|...:...|||:
Human   316 ERPRESSCHIVTISSSE 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-C	NP_572358.1	7tm_4	61..332	CDD:304433	74/292 (25%)
mAChR-C	NP_572358.1	7tm_1	67..321	CDD:278431	68/264 (26%)
GPR119	NP_848566.1	7tmA_GPR119_R_insulinotropic_receptor	6..290	CDD:320232	77/295 (26%)
		TM helix 1	7..32	CDD:320232	11/29 (38%)
		TM helix 2	40..66	CDD:320232	10/25 (40%)
		TM helix 3	78..108	CDD:320232	11/29 (38%)
		TM helix 4	120..140	CDD:320232	5/19 (26%)
		TM helix 5	162..191	CDD:320232	4/28 (14%)
		TM helix 6	218..248	CDD:320232	9/29 (31%)
		TM helix 7	258..283	CDD:320232	8/24 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910