DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mAChR-C and Adora2a

DIOPT Version :9

Sequence 1:	NP_572358.1	Gene:	mAChR-C / 31626	FlyBaseID:	FBgn0029909	Length:	371	Species:	Drosophila melanogaster
Sequence 2:	NP_001318024.1	Gene:	Adora2a / 11540	MGIID:	99402	Length:	410	Species:	Mus musculus

Alignment Length:	328	Identity:	93/328 - (28%)
Similarity:	150/328 - (45%)	Gaps:	53/328 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 GHLLWLAINAFLFVLILGGNILTIVAVRTCRHLRSVISNLFILSLAVSDFCVG-LALPYHLVFYM 112
            |..:::.:...:.||.:.||:|...||....:|::| :|.|::|||.:|..|| ||:|:.:....
Mouse     2 GSSVYIMVELAIAVLAILGNVLVCWAVWINSNLQNV-TNFFVVSLAAADIAVGVLAIPFAITIST 65

  Fly   113 GSDIGAMRGPCLLRFFLLICACCVSMLT------LISIAVDRYIAVVYALHYRRYMTRRVAYSII 171
            |. ..|..| ||  ||    ||.|.:||      |::||:|||||:...|.|...:|...|..||
Mouse    66 GF-CAACHG-CL--FF----ACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGMRAKGII 122

  Fly   172 IFNWCLGALVALLPVF-WNRWPDAQ------------ACEFDEVLAPGYIAGVITPGFVII-WIC 222
            ...|.|...:.|.|:. ||......            .|.|::|:...|:.......||:: .:.
Mouse   123 AICWVLSFAIGLTPMLGWNNCSQKDENSTKTCGEGRVTCLFEDVVPMNYMVYYNFFAFVLLPLLL 187

  Fly   223 MFLVYWRIMREASKQALRLRQSVVYNTDEATTMRNLLLHPDWKSVQIVVFIMGCFTLCWLP---- 283
            |..:|.||...|.:|..::....:......:|     |..:..:.:.:..|:|.|.|||||
Mouse   188 MLAIYLRIFLAARRQLKQMESQPLPGERTRST-----LQKEVHAAKSLAIIVGLFALCWLPLHII 247

  Fly   284 ----YFCVAIAQLFSICQSSS--MIYKTTFSLAIANSALNPIIYSWKNSGFRRAFVQTLCCRTAR 342
                :||       |.||.:.  ::| ....|:.:||.:||.||:::...||:.|.:.:.....|
Mouse   248 NCFTFFC-------STCQHAPPWLMY-LAIILSHSNSVVNPFIYAYRIREFRQTFRKIIRTHVLR 304

  Fly   343 QCE 345
            :.|
Mouse   305 RQE 307

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-C	NP_572358.1	7tm_4	61..332	CDD:304433	89/301 (30%)
mAChR-C	NP_572358.1	7tm_1	67..321	CDD:278431	83/284 (29%)
Adora2a	NP_001318024.1	7tmA_Adenosine_R_A2A	4..294	CDD:320196	89/311 (29%)
		TM helix 1	5..31	CDD:320196	7/25 (28%)
		TM helix 2	38..65	CDD:320196	11/26 (42%)
		TM helix 3	74..104	CDD:320196	17/35 (49%)
		TM helix 4	118..136	CDD:320196	6/17 (35%)
		Agonist binding. /evidence=ECO:0000250	163..172		2/8 (25%)
		TM helix 5	169..199	CDD:320196	7/29 (24%)
		TM helix 6	221..251	CDD:320196	8/29 (28%)
		Agonist binding. /evidence=ECO:0000250	241..248		3/6 (50%)
		Agonist binding. /evidence=ECO:0000250	259..269		1/10 (10%)
		TM helix 7	262..287	CDD:320196	8/25 (32%)
		Interaction with GAS2L2. /evidence=ECO:0000250\|UniProtKB:P30543	322..410
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	342..410
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D252862at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920