| Sequence 1: | NP_572358.1 | Gene: | mAChR-C / 31626 | FlyBaseID: | FBgn0029909 | Length: | 371 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_000731.1 | Gene: | CHRM3 / 1131 | HGNCID: | 1952 | Length: | 590 | Species: | Homo sapiens |
| Alignment Length: | 292 | Identity: | 71/292 - (24%) |
|---|---|---|---|
| Similarity: | 120/292 - (41%) | Gaps: | 41/292 - (14%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 5 SSSSP-------AWDYRSSPEALGVVPFLWQHQNATETPTEITLQATSFGA----------GHLL 52
Fly 53 WLAI-----NAFLFVLILGGNILTIVAVRTCRHLRSVISNLFILSLAVSDFCVGLALPYHLVFYM 112
Fly 113 GSDIGAMRG-PCLLRFFLLICACCVSMLTLISIAVDRYIAVVYALHYRRYMTRRVAYSIIIFNWC 176
Fly 177 LG-ALVALLPVFWNRW------PDAQACEFDEVLAPGYIAGVITPGFVIIWICMFLVYWRIMREA 234
Fly 235 SKQALRLRQSVVYNTDEATTMRNLLLHPDWKS 266 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| mAChR-C | NP_572358.1 | 7tm_4 | 61..332 | CDD:304433 | 56/214 (26%) |
| 7tm_1 | 67..321 | CDD:278431 | 56/208 (27%) | ||
| CHRM3 | NP_000731.1 | 7tmA_mAChR_M3 | 66..>270 | CDD:320426 | 53/205 (26%) |
| TM helix 1 | 70..96 | CDD:320426 | 7/25 (28%) | ||
| TM helix 2 | 103..130 | CDD:320426 | 9/26 (35%) | ||
| TM helix 3 | 141..171 | CDD:320426 | 9/29 (31%) | ||
| Agonist binding. /evidence=ECO:0000250 | 148..152 | 0/3 (0%) | |||
| TM helix 4 | 183..206 | CDD:320426 | 5/22 (23%) | ||
| TM helix 5 | 228..257 | CDD:320426 | 8/28 (29%) | ||
| Basolateral sorting signal | 275..281 | 1/8 (13%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 323..357 | ||||
| 7tm_GPCRs | <484..564 | CDD:391938 | |||
| TM helix 6 | 487..512 | CDD:341315 | |||
| Agonist binding. /evidence=ECO:0000250 | 507..530 | ||||
| TM helix 7 | 523..548 | CDD:341315 | |||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 0 | 0.000 | Not matched by this tool. | |||
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 1 | 0.910 | |||||