DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mAChR-C and gpr52

DIOPT Version :9

Sequence 1:	NP_572358.1	Gene:	mAChR-C / 31626	FlyBaseID:	FBgn0029909	Length:	371	Species:	Drosophila melanogaster
Sequence 2:	XP_021325264.1	Gene:	gpr52 / 101884270	ZFINID:	ZDB-GENE-050208-696	Length:	370	Species:	Danio rerio

Alignment Length:	342	Identity:	96/342 - (28%)
Similarity:	154/342 - (45%)	Gaps:	45/342 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 LLWLAINAFLFVLILGGNILTIVAVRTCRH-LRSVISNLFILSLAVSDFCVGLA--LP-YHLVFY 111
            :|..|:...|.|||:.|| ||::.|..|.. |....::.||.::|.:|..|||:  :| ..|:.|
Zfish    43 VLETAVIVLLTVLIIAGN-LTVIFVFHCAPLLHHYTTSYFIQTMAYADLLVGLSCLVPTLSLLHY 106

  Fly   112 MGSDIGAMRGP--CLLRFFLLICACCVSMLTLISIAVDRYIAVVYALHYRRYMTRRVAYSIIIFN 174
            .    ..::.|  |.:..:::.....|||..|..|:||||:|:...|.|.:.:|.......||..
Zfish   107 P----AGVQEPITCQVFSYIISVLKSVSMACLACISVDRYLAITKPLSYNQLVTPCRLRCCIILI 167

  Fly   175 WCLGALVALLPVF--------------W--NRWPDAQACEFDEVLAPGYIAGVI-TPGFVIIWIC 222
            | :.:.|..||.|              |  |.||.:       .|..|::..:: .|..:::...
Zfish   168 W-IYSCVVFLPSFFGWGKPGYHGDIFEWCANSWPTS-------ALFTGFVVCLLYAPAALVVCFT 224

  Fly   223 MFLVYWRIMREASKQALRLRQSVVYNTDEATTMRNLLLH-PDWKSVQIVVFIMGCFTLCWLPYFC 286
            .|.:: ||.::.:::....|........|.|...|...| ||.:...::..|...|.:.||||..
Zfish   225 YFHIF-RICQQHNREISERRARFPSQEMETTEGGNPAGHGPDRRYAMVLFRITSVFYMLWLPYIF 288

  Fly   287 VAIAQLFSICQSSSMIYKTTFSLAIANSALNPIIYSWKNSGFR---RAFVQTLCCRTA-RQC--E 345
            ..:.:...:..|.::.:.||: |||:||..|.:|||..||.||   |...||||...: ..|  :
Zfish   289 YFLLESSHVLDSPALSFVTTW-LAISNSFCNCVIYSLSNSVFRLGMRRLSQTLCSSCSFSPCTHD 352

  Fly   346 DQLPADSKHRMEATSSS 362
            |:...:.|.|..|.|.|
Zfish   353 DKDFGEPKPRKRANSCS 369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-C	NP_572358.1	7tm_4	61..332	CDD:304433	82/297 (28%)
mAChR-C	NP_572358.1	7tm_1	67..321	CDD:278431	71/277 (26%)
gpr52	XP_021325264.1	7tm_classA_rhodopsin-like	45..326	CDD:320086	79/295 (27%)
		TM helix 1	45..70	CDD:320086	10/25 (40%)
		TM helix 2	78..104	CDD:320086	8/25 (32%)
		TM helix 3	116..146	CDD:320086	11/29 (38%)
		TM helix 4	159..178	CDD:320086	5/19 (26%)
		TM helix 5	202..227	CDD:320086	3/31 (10%)
		TM helix 6	252..293	CDD:320086	12/40 (30%)
		TM helix 7	301..326	CDD:320086	11/25 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24249
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010