DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mAChR-C and adora3.1

DIOPT Version :9

Sequence 1:	NP_572358.1	Gene:	mAChR-C / 31626	FlyBaseID:	FBgn0029909	Length:	371	Species:	Drosophila melanogaster
Sequence 2:	XP_002932848.2	Gene:	adora3.1 / 100496142	XenbaseID:	XB-GENE-22169673	Length:	325	Species:	Xenopus tropicalis

Alignment Length:	333	Identity:	91/333 - (27%)
Similarity:	158/333 - (47%)	Gaps:	68/333 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 TETPTEITLQATS-FGAGHLLWLAINAFLFVLILGGNILTIVAVRTCRHLRSVISNLFILSLAVS 96
            ||:.|.|.:...| .||..:|              ||.|.|.|||....|:.. :..|::|||::
Frog     6 TESLTTIYIVTESLIGATAVL--------------GNTLVIWAVRLNPALQDA-TFYFVVSLAIA 55

  Fly    97 DFCVG-LALPYHLVFYMGSDIGAMRGPCLLRFFLLICACC-------VSMLTLISIAVDRYIAVV 153
            ||.|| |.:|..::..|         ...:.|.:.:..||       .|:|:|::|::|||:.:.
Frog    56 DFAVGVLVMPLAIILNM---------EIQMHFHVCLFVCCSIIILTNASILSLLAISIDRYLRIR 111

  Fly   154 YALHYRRYMTRRVAYSIIIFNWCLGALVALLPVF-WNRWP-------DAQACEFDEVLAPGYI-- 208
            ..:.||..:.::..:..|:|:|.|.||.|||||| ||...       |...|||.:|::..::
Frog   112 IPIRYRSVVRKKRIFICILFSWILSALGALLPVFGWNHRSNLEENERDYLRCEFIKVMSLDFLVY 176

  Fly   209 ----AGVITPGFVIIWICMFLVYWRIMREASKQALRLRQSV--VYNTDEATTMRNLLLHPDWKSV 267
                ..|:.|.|:::.:...:.|  ::::..:..:.:.|..  .|:.:..|.          .|:
Frog   177 FCFFGWVVIPLFLMVGLYTQIFY--LIQKNRRHNISIHQGKQNYYSKEHRTA----------SSL 229

  Fly   268 QIVVFIMGCFTLCWLPYFCVAIAQLF--SICQSSSM--IYKTTFSLAIANSALNPIIYSWKNSGF 328
            .:|:|:   |.|||||...|.....|  |:.::|:.  :...|..|:.||||:|||:|::|...|
Frog   230 ALVMFL---FALCWLPISIVNCISYFYPSVAENSTFQPVVLLTILLSHANSAMNPIVYAFKIRKF 291

  Fly   329 RRAFVQTL 336
            :..|:..:
Frog   292 KYTFLSII 299

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-C	NP_572358.1	7tm_4	61..332	CDD:304433	82/298 (28%)
mAChR-C	NP_572358.1	7tm_1	67..321	CDD:278431	79/281 (28%)
adora3.1	XP_002932848.2	7tm_GPCRs	11..295	CDD:391938	87/322 (27%)
		TM helix 1	13..37	CDD:341315	10/37 (27%)
		TM helix 2	46..68	CDD:341315	10/21 (48%)
		TM helix 3	82..104	CDD:341315	6/21 (29%)
		TM helix 4	127..143	CDD:341315	8/15 (53%)
		TM helix 5	172..195	CDD:341315	3/22 (14%)
		TM helix 6	223..248	CDD:341315	11/37 (30%)
		TM helix 7	263..288	CDD:341315	10/24 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D252862at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920