Protein Alignment mAChR-C and hrh1

DIOPT Version :10

• Sequence 1: NP_572358.1
• Gene: mAChR-C / 31626
• FlyBaseID: FBgn0029909
• Length: 371
• Species: Drosophila melanogaster
• Sequence 2: XP_031757131.1
• Gene: hrh1 / 100495566
• XenbaseID: XB-GENE-6031155
• Length: 499
• Species: Xenopus tropicalis
• Alignment Length: 488
• Identity: 97/488 - (19%)
• Similarity: 158/488 - (32%)
• Gaps: 194/488 - (39%)

  Fly    26 LWQ-HQNATETPTEITLQATSFGAGHLLWLAINAFLFVLILGGNILTIVAVRTCRHLRSVISNLF 89
            :|| :|:..:..|||...:.....|     .|:|...||    |||.:.||||.|.|.:| .||:
 Frog     1 MWQTNQSIVQNGTEIHSASLGLALG-----TISALTVVL----NILVLYAVRTERKLHTV-GNLY 55

  Fly    90 ILSLAVSDFCVGLA-LPYHLVFYMGSDIGAMRGPCLLRFFLLICACCVSMLTLISIAVDRYIAVV 153
            |:||:::|..||.| :|.::|:.:..:....|..||....:...|...|:.:|..:.:|||.::.
 Frog    56 IVSLSIADLIVGAAVMPLNIVYLLNREWILGRPACLFWLSMDYVASTASIFSLFILCIDRYRSIQ 120

  Fly   154 YALHYRRYMTRRVAYSIIIFNWCLGALVALLPVF-WN-------RWPDAQAC--EFDEVLAPGYI 208
            ..|.|.:|.|:..|..:|...|.| :...::|:. |:       |......|  ||.:|.....:
 Frog   121 QPLRYLKYRTKTRASLMISGAWLL-SFTWVVPILGWHVFANGGIRSVPESTCETEFHKVTWFKVL 184

  Fly   209 AGVIT---PGFVIIWI------------------------------------------------- 221
            ...:.   |..:::|.
 Frog   185 TATLNFYIPSLLMLWFYAKIYKAVREHYQHREVVNGSFQLFYDSKLVQSVRVLKGQQSCTKTQCK 249

  Fly   222 ------------------------------------------------------CMFLV------ 226
                                                                  |..|.
 Frog   250 DGNLTVPEMNFPAQYTPISKEFRQSRSTQEKDPVEDYGKQKGFSHCDNNVFKLHCFPLAIIQGSP 314

  Fly   227 -----YWRIMREASKQ--ALRLRQ--------------------SVV------------------ 246
                 |..:.|.|.::  .||.||                    |.|
 Frog   315 QECRNYVTVTRGALEEHNCLRPRQREEISEEHTFAEAASCMVDLSQVGKSNMEAPGRTEARLSGN 379

  Fly   247 ----------YNTDEATTMRNLLLHPDWKSVQIVVFIMGCFTLCWLPYFC--VAIAQLFSICQSS 299
                      :.|.....::.|.::.:.|:.:.:.|||..|.|||:|||.  :.||...:.|..:
 Frog   380 FRYLKHTWERFRTHSKQHIQGLHMNRERKAAKQLGFIMAAFMLCWIPYFVLFMVIAFCHNCCNHN 444

  Fly   300 SMIYKTTFSLAIANSALNPIIYSWKNSGFRRAF 332
            ..::  |..|...||.|||:||...|..|::.|
 Frog   445 FHMF--TIWLGYINSTLNPLIYPLCNENFKKTF 475

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-C	NP_572358.1	7tm_classA_rhodopsin-like	53..325	CDD:410626	87/451 (19%)
		TM helix 1	53..78	CDD:410626	10/24 (42%)
		TM helix 2	86..111	CDD:410626	11/25 (44%)
		TM helix 3	123..153	CDD:410626	8/29 (28%)
		TM helix 4	166..185	CDD:410626	4/18 (22%)
		TM helix 5	204..229	CDD:410626	5/141 (4%)
		TM helix 6	261..291	CDD:410626	12/31 (39%)
		TM helix 7	300..325	CDD:410626	9/24 (38%)
hrh1	XP_031757131.1	7tmA_Histamine_H1R	18..475	CDD:320178	90/469 (19%)
		TM helix 1	19..45	CDD:320178	11/34 (32%)
		TM helix 2	52..78	CDD:320178	11/25 (44%)
		TM helix 3	90..120	CDD:320178	8/29 (28%)
		TM helix 4	132..153	CDD:320178	5/21 (24%)
		TM helix 5	178..322	CDD:320178	6/143 (4%)
		TM helix 6	404..434	CDD:320178	11/29 (38%)
		TM helix 7	443..468	CDD:320178	9/26 (35%)