DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mAChR-C and taar19b

DIOPT Version :9

Sequence 1:	NP_572358.1	Gene:	mAChR-C / 31626	FlyBaseID:	FBgn0029909	Length:	371	Species:	Drosophila melanogaster
Sequence 2:	XP_021335134.1	Gene:	taar19b / 100333348	ZFINID:	ZDB-GENE-091116-74	Length:	334	Species:	Danio rerio

Alignment Length:	311	Identity:	77/311 - (24%)
Similarity:	142/311 - (45%)	Gaps:	43/311 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 GHLLWLAINAFLFVLILGGNILTIVAVRTCRHLRSVISNLFILSLAVSDFCVGL-ALPYHLV--- 109
            |::::|.: :||....:..|:|.|:::...:.|.:. :|:.:|||||:|..:|| .:|...|
Zfish    30 GYIIYLFV-SFLSAWTVFLNLLVIISISHFKKLHTP-TNMIVLSLAVADLLIGLIVMPVEAVKLI 92

  Fly   110 ---FYMGSDIGAMRGPCLLRFFLLICACCVSMLTLISIAVDRYIAVVYALHYRRYMTRRVAYSII 171
               :|.|...      |.....|:......|:..|:.||||||.||.:.|.|.:.:|.......|
Zfish    93 ETCWYFGDTF------CGFTLILIGVIPSASLGNLVLIAVDRYAAVCHPLLYPQKITMANMLMSI 151

  Fly   172 IFNWCLGALVALLPVFWNRWPD----AQACEFDEVLAPGYIAGVITPGFV-IIWICMFLV--YWR 229
            ..:|...:......|.:||:.|    ...| :.:.|.....:.::|..|| .::.|:.::  |.|
Zfish   152 CLSWVYYSTYITTLVIYNRYFDTSHRTDEC-YGQCLVMMSFSWILTDLFVCFVFPCVLIITLYLR 215

  Fly   230 IMREASKQALRLRQSVVYNTDEATTMRNLLLHPDWKSVQIVVFIMGCFTLCWLPYFCVAIAQLFS 294
            |.....:| :::..|:: ...:..|..::....:.|:...:..|:..:.|||:||:
Zfish   216 IFYVVHQQ-VKVINSLM-KGGKCVTEGSVKRKSESKAALTLGIIVSVYLLCWIPYY--------- 269

  Fly   295 IC----QSSSMIYKTTFSLAIANSALNPIIYS----WKNSGFRRAFVQTLC 337
            ||    .||:::...|:.| .|||.|||::|:    |.....:.....|:|
Zfish   270 ICTLTVNSSTVLSVLTWVL-YANSGLNPLVYALFYPWFKKTVKHILTMTIC 319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-C	NP_572358.1	7tm_4	61..332	CDD:304433	71/292 (24%)
mAChR-C	NP_572358.1	7tm_1	67..321	CDD:278431	69/271 (25%)
taar19b	XP_021335134.1	7tmA_TAARs	32..310	CDD:320183	74/298 (25%)
		TM helix 1	32..58	CDD:320183	6/26 (23%)
		TM helix 2	65..91	CDD:320183	11/25 (44%)
		TM helix 3	103..133	CDD:320183	11/29 (38%)
		TM helix 4	145..168	CDD:320183	3/22 (14%)
		TM helix 5	190..219	CDD:320183	7/28 (25%)
		TM helix 6	245..275	CDD:320183	9/38 (24%)
		TM helix 7	278..303	CDD:320183	10/25 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24249
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100