DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mAChR-C and taar20x

DIOPT Version :9

Sequence 1:	NP_572358.1	Gene:	mAChR-C / 31626	FlyBaseID:	FBgn0029909	Length:	371	Species:	Drosophila melanogaster
Sequence 2:	XP_017213648.1	Gene:	taar20x / 100150393	ZFINID:	ZDB-GENE-060413-10	Length:	331	Species:	Danio rerio

Alignment Length:	310	Identity:	84/310 - (27%)
Similarity:	134/310 - (43%)	Gaps:	73/310 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 AFLFVLILGG-----NILTIVAVRTCRHLRSVISNLFILSLAVSDFCVGLALPYHLV------FY 111
            |:|.|.:|..     |:|.|:::...:.|.:. :|:.||||||:|..:||.:|...|      :|
Zfish    33 AYLLVSLLSAWTVFLNLLVIISISHFKKLHTP-TNMIILSLAVNDLFIGLIMPIEAVRLIETCWY 96

  Fly   112 MGSDIGAMRGPCLLRFFLLICACCVSMLTLISIAVDRYIAVVYALHYRRYMTRRVAYSIIIFNW- 175
            .|...      |.|....::.....|:..|:.||||||:||.:.|.|.:.:|....:..|...|
Zfish    97 FGDTF------CNLYLIFIVILLSASLSNLVLIAVDRYVAVCHPLLYPQKITITKTFMCICMCWV 155

  Fly   176 CLGALVALLPVFWNRWPDAQACEFDEVLAPGYIAGV--------------ITPGFV-IIWICMFL 225
            |..|....| |..|.:       ||    |.:..||              :|..|| .|:.|..:
Zfish   156 CFSAYCTAL-VINNSY-------FD----PSHRTGVCYGQCLVLMSFSWTVTDLFVGFIFPCALI 208

  Fly   226 V--YWRIMREASKQALRLRQSVVYNTDEATTMRNLLLH-PDWKSVQIVVFIMGCFTLCWLPYFCV 287
            :  |.||......| :::..|::......|  .|||.. .:.|:...:.||:..:.|||:|::
Zfish   209 ITLYLRIFYVVHLQ-VKVINSLMKGGKSVT--ENLLKRKSESKAALTLGFIVTVYLLCWIPFY-- 268

  Fly   288 AIAQLFSICQSSSMIYKTTFSLAI-----ANSALNPIIYS----W-KNSG 327
                   ||  |..:|.:|....:     :||.|||::|:    | |.:|
Zfish   269 -------IC--SLTVYSSTAMNVLIWAVHSNSGLNPLVYALFYPWFKKTG 309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-C	NP_572358.1	7tm_4	61..332	CDD:304433	82/307 (27%)
mAChR-C	NP_572358.1	7tm_1	67..321	CDD:278431	76/288 (26%)
taar20x	XP_017213648.1	7tmA_TAARs	32..308	CDD:320183	83/307 (27%)
		TM helix 1	32..58	CDD:320183	7/24 (29%)
		TM helix 2	65..90	CDD:320183	12/24 (50%)
		TM helix 3	102..132	CDD:320183	11/29 (38%)
		TM helix 4	144..167	CDD:320183	6/23 (26%)
		TM helix 5	189..218	CDD:320183	8/28 (29%)
		TM helix 6	244..274	CDD:320183	10/40 (25%)
		TM helix 7	277..302	CDD:320183	7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24249
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100