DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mAChR-C and drd1c

DIOPT Version :9

Sequence 1:	NP_572358.1	Gene:	mAChR-C / 31626	FlyBaseID:	FBgn0029909	Length:	371	Species:	Drosophila melanogaster
Sequence 2:	XP_004915948.1	Gene:	drd1c / 100124855	XenbaseID:	XB-GENE-5919679	Length:	465	Species:	Xenopus tropicalis

Alignment Length:	382	Identity:	112/382 - (29%)
Similarity:	170/382 - (44%)	Gaps:	79/382 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 HQNATETPTEITLQATSFGAGHLLWLAINAFLFVLILGGNILTIVAVRTCRHLRSVISNLFILSL 93
            |.:.....::::|:|.:   |.||.|.|.:.|.     ||.|..:||...|||||.::|.|::||
Frog    15 HADLDVGSSDLSLRALT---GLLLSLLILSTLL-----GNTLVCLAVIKFRHLRSKVTNFFVISL 71

  Fly    94 AVSDFCVG-LALPYHLV-----FYMGSDIGAMRGPCLLRFFLLICACCVSMLTLISIAVDRYIAV 152
            ||||..|. |.:|:..|     :::..|.      |.......|.....|:|.|..|::|||.|:
Frog    72 AVSDLFVALLVMPWKAVTEVAGYWLFGDF------CDTWVAFDIMCSTASILNLCIISLDRYWAI 130

  Fly   153 VYALHYRRYMTRRVAYSIIIFNWCLGALVALLPV--FWNRWPD----------AQACEFDEVLAP 205
            .....|.|.||:|||:.:|...|.|..|::.:||  .|::..:          .:.|  |..|..
Frog   131 ASPFRYERKMTQRVAFIMIGVAWTLSILISFIPVQLSWHKSQEVDEELNAINHTENC--DSSLNR 193

  Fly   206 GYIAGVITPGFVIIWICMFLVYWRIMREASKQALRLRQSVVYNTDEATTMRNLLLHPD------- 263
            .|........|.|..:.|...|.||.|.|..|..|: .|:....:.|.:.     |||
Frog   194 TYAISSSLISFYIPVVIMIGTYTRIYRIAQTQIRRI-SSLERAVEHAQSG-----HPDCSNENSL 252

  Fly   264 -------WKSVQIVVFIMGCFTLCWLPYFCVAIAQLFSICQSS---------SMIYKTTFSLAI- 311
                   .|.::.:..|||.|..||||:|  .:..:...|..|         ..:.:|||::.:
Frog   253 KTSFRKETKVLKTLSIIMGVFVFCWLPFF--VLNCMIPFCHMSLPGQNEPEPPCVSETTFNIFVW 315

  Fly   312 ---ANSALNPIIYSWKNSGFRRAFVQTLCCRTARQCEDQLPADSKHRMEATSSSQEI 365
               |||:|||:||:: |:.||:||...|.|.  |.|       |.:.:||.:.|.|:
Frog   316 FGWANSSLNPVIYAF-NADFRKAFTTILGCN--RFC-------SSNNVEAVNFSNEL 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-C	NP_572358.1	7tm_4	61..332	CDD:304433	92/315 (29%)
mAChR-C	NP_572358.1	7tm_1	67..321	CDD:278431	87/298 (29%)
drd1c	XP_004915948.1	7tmA_D1-like_dopamine_R	46..338	CDD:320185	91/308 (30%)
		TM helix 2	64..91	CDD:320185	12/26 (46%)
		TM helix 3	101..131	CDD:320185	10/29 (34%)
		TM helix 4	143..163	CDD:320185	7/19 (37%)
		TM helix 5	192..222	CDD:320185	8/29 (28%)
		TM helix 6	257..287	CDD:320185	10/31 (32%)
		TM helix 7	307..332	CDD:320185	11/25 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910