DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mAChR-C and adrb2b

DIOPT Version :9

Sequence 1:	NP_572358.1	Gene:	mAChR-C / 31626	FlyBaseID:	FBgn0029909	Length:	371	Species:	Drosophila melanogaster
Sequence 2:	NP_001082940.2	Gene:	adrb2b / 100037315	ZFINID:	ZDB-GENE-070410-32	Length:	409	Species:	Danio rerio

Alignment Length:	395	Identity:	109/395 - (27%)
Similarity:	180/395 - (45%)	Gaps:	83/395 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 SSPEALGVVPFLWQHQNATETPTEITLQATSFGAGHLLWLAINAFLFVLILGGNILTIVAVRTCR 79
            |||.:|.|..:         :..|:.|.:...|           .|.::|:.||.|.|.|:...:
Zfish    25 SSPVSLSVSEY---------SDAEVVLISILIG-----------ILVLVIVFGNALVISAIVRFQ 69

  Fly    80 HLRSVISNLFILSLAVSDFCVGL-ALPYHLVFYMGSDIGAMRGPCLL------------RFFLLI 131
            .|::| :|.||.|||.:|..:|| .:|:              |.|.:            .|:...
Zfish    70 RLQTV-TNYFISSLACADLVMGLMVVPF--------------GACYILLNTWHFGNFFCEFWTAT 119

  Fly   132 CACCV--SMLTLISIAVDRYIAVVYALHYRRYMTRRVAYSIIIFNWCLGALVALLPVFWNRW--- 191
            ...||  |:.||..||:|||||:::.|.|:..:|:|.|..::|..|.:.||::.||:....|
Zfish   120 DVLCVTASIETLCVIALDRYIAIMWPLRYQSMLTKRKACGMVIGVWAVAALISFLPIHMEWWVSD 184

  Fly   192 -PDA-------QACEFDEVLAPGYIAGVITPGFVIIWICMFLVYWRIMREASKQALRL------- 241
             |:|       ..|:|:...|....:.:|:  |.|..:.|..||.|:.:||.:|..::
Zfish   185 EPEALSCLEEPTCCDFNTNAAYAVTSSIIS--FYIPLVIMAFVYSRVFQEARRQLQKIDRIEGRI 247

  Fly   242 -RQSVVYNTDEATTMRN---LLLHPDWKSVQIVVFIMGCFTLCWLPYFCVAIAQLFSICQSSSMI 302
             .||:  :|.|...::|   .....|.|:::.:..|||.|||||||:|.:.:........:..:.
Zfish   248 RTQSL--STQEGNEIKNRRTKFCMKDHKALKTLGIIMGTFTLCWLPFFVLNVVAAIWKMDNIMLP 310

  Fly   303 YKTTFSLAIANSALNPIIYSWKNSGFRRAFVQTLCCRTARQCEDQLPAD-SKHRMEATSSSQEIK 366
            ::....:..||||.||:||. ::..||.||.:.||.|.:     .||:. ||.....:..|.::.
Zfish   311 FRILNWIGYANSAFNPLIYC-RSPEFRCAFQEILCWRPS-----HLPSTRSKKGYLYSGHSWKVH 369

  Fly   367 PKATQ 371
            .|.|:
Zfish   370 TKTTR 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-C	NP_572358.1	7tm_4	61..332	CDD:304433	88/307 (29%)
mAChR-C	NP_572358.1	7tm_1	67..321	CDD:278431	83/290 (29%)
adrb2b	NP_001082940.2	7tm_GPCRs	41..339	CDD:333717	91/328 (28%)
		TM helix 1	43..67	CDD:320095	8/34 (24%)
		TM helix 2	76..98	CDD:320095	10/35 (29%)
		TM helix 3	114..136	CDD:320095	7/21 (33%)
		TM helix 4	159..175	CDD:320095	4/15 (27%)
		TM helix 5	204..227	CDD:320095	6/24 (25%)
		TM helix 6	272..297	CDD:320095	12/24 (50%)
		TM helix 7	308..333	CDD:320095	8/25 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910