Protein Alignment mAChR-C and taar12b

DIOPT Version :10

• Sequence 1: NP_572358.1
• Gene: mAChR-C / 31626
• FlyBaseID: FBgn0029909
• Length: 371
• Species: Drosophila melanogaster
• Sequence 2: NP_001076573.1
• Gene: taar12b / 100034646
• ZFINID: ZDB-GENE-041014-69
• Length: 337
• Species: Danio rerio
• Alignment Length: 311
• Identity: 78/311 - (25%)
• Similarity: 127/311 - (40%)
• Gaps: 70/311 - (22%)

  Fly    60 LFVLILG---GNILTIVAVRTCRHLRSVISNLFILSLAVSDFCVG-LALPYHLV------FYMGS 114
            |.::||.   ||:|.|:::...:||:|. ::|.:.|||..|..:| |.:||.:|      :|:|.
Zfish    39 LLLMILTTVFGNLLIIISISHFKHLQSP-THLIVQSLAACDCLMGSLVMPYSMVRSVEGCWYLGD 102

  Fly   115 DIGAMRGPCLLRFFLLICACCVSMLTLISIAVDRYIAVVYALHYRRYMTRRVAYSIIIFNW---- 175
            .:      |.:...|.:..|..|:|.|..|:||||.|:...|.||..:|.......||..|
Zfish   103 VV------CKVHSSLDMTFCMSSLLHLGLISVDRYWAICDPLRYRLRVTNTTVTVFIIVIWLFSF 161

  Fly   176 ------------------------CLGALVALLPVFWNRWPDAQACEFDEVLAPGYIAGVITPGF 216
                                    |:|:.:.|....|..:|          ....:|.|.|
Zfish   162 IYNFSIVFSGITAVGLEMLILQTYCVGSCIVLFNKEWAVYP----------FLTFFITGAI---- 212

  Fly   217 VIIWICMFLVYWRIMREASKQALRLRQSVVYNTDEATTMRNLLLHPDWKSVQIVVFIMGCFTLCW 281
                  |..:|.:|...|.|.|..:.:.|.......::.:.     :.|:.:.:..:||.|..||
Zfish   213 ------MSSLYMKIFHVAQKHAKVMSERVTGGLKSQSSAQR-----ERKAAKTLAIVMGVFMFCW 266

  Fly   282 LPYFCVAIAQLFSICQSSSMIYKTTFSLAIANSALNPIIYSWKNSGFRRAF 332
            |||........|....:|:.::...|..|..||:.||:||.:....|::||
Zfish   267 LPYCAFTALYPFFTFLNSAEVFDVLFWFAYFNSSCNPVIYGFFYPCFQKAF 317

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-C	NP_572358.1	7tm_classA_rhodopsin-like	53..325	CDD:410626	75/302 (25%)
		TM helix 1	53..78	CDD:410626	7/20 (35%)
		TM helix 2	86..111	CDD:410626	10/31 (32%)
		TM helix 3	123..153	CDD:410626	12/29 (41%)
		TM helix 4	166..185	CDD:410626	6/46 (13%)
		TM helix 5	204..229	CDD:410626	5/24 (21%)
		TM helix 6	261..291	CDD:410626	9/29 (31%)
		TM helix 7	300..325	CDD:410626	8/24 (33%)
taar12b	NP_001076573.1	7tm_GPCRs	33..317	CDD:475119	76/309 (25%)
		TM helix 1	35..59	CDD:410628	7/19 (37%)
		TM helix 2	68..90	CDD:410628	9/21 (43%)
		TM helix 3	106..128	CDD:410628	6/21 (29%)
		TM helix 4	151..167	CDD:410628	3/15 (20%)
		TM helix 5	196..218	CDD:410628	6/41 (15%)
		TM helix 6	252..274	CDD:410628	8/21 (38%)
		TM helix 7	285..310	CDD:410628	8/24 (33%)