DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mAChR-C and LOC100007535

DIOPT Version :9

Sequence 1:	NP_572358.1	Gene:	mAChR-C / 31626	FlyBaseID:	FBgn0029909	Length:	371	Species:	Drosophila melanogaster
Sequence 2:	XP_001345968.4	Gene:	LOC100007535 / 100007535	-ID:	-	Length:	312	Species:	Danio rerio

Alignment Length:	328	Identity:	90/328 - (27%)
Similarity:	152/328 - (46%)	Gaps:	55/328 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 LWLAINAFLFVLILGGNILTIVAVRTCRHLRSVISNLFILSLAVSDFCVG-LALPYHLVFYMGSD 115
            |::.:...:.:..:.||::.:.|||..|.||.. :..||:|||::|..|| |.:|..:...:|..
Zfish     7 LYIGMELLIALFSVIGNVMVVWAVRINRTLRDT-TIYFIVSLALADIAVGALVIPLAITISIGLK 70

  Fly   116 IGAMRGPCLLRFFLLICACCV------SMLTLISIAVDRYIAVVYALHYRRYMTRRVAYSIIIFN 174
            ...        :..|:.||.|      |:|.|::||:|||:.|...:.|:|.:|...|.:.::..
Zfish    71 TNF--------YSCLLVACTVLVLTQSSILALLAIAIDRYLRVKIPMSYKRVVTPNRAGAAVVVC 127

  Fly   175 WCLGALVALLPVF-WNRWPDAQ------------ACEFDEVLAPGYIA-----GVITPGFVIIWI 221
            |.:..:|.|:|:. ||.....|            .|||:.|::..|:.     |.:.|..::
Zfish   128 WMVAIVVGLMPMLGWNNLDKLQQTNGTVGVDLLITCEFENVISMEYMVYFNFFGWVLPPLIL--- 189

  Fly   222 CMFLVYWRIMREASKQALRLRQSVVYNTDEATTM--RNLLLHPDWKSVQIVVFIMGCFTLCWLPY 284
             |.|:|..|.....||   |.:.|:.|..:.|..  :.|.|.   ||:.:|:.:   |.:.|||.
Zfish   190 -MLLIYIEIFFIIHKQ---LNKKVITNQTDPTRYYGKELKLA---KSLALVLLL---FAVSWLPL 244

  Fly   285 FCVAIAQLF-SICQSSSMIYKTTFSLAIANSALNPIIYSWKNSGFRRAFV----QTLCCRTARQC 344
            ..:....|| ..|.:|..:......|:..||.:|||:|:::...|:.||:    |.:|| |...|
Zfish   245 HILNCITLFCPNCDNSMCLLYVAILLSHGNSVVNPIVYAFRIKKFQNAFLRIWKQYVCC-TDSPC 308

  Fly   345 EDQ 347
            ..|
Zfish   309 LSQ 311

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAChR-C	NP_572358.1	7tm_4	61..332	CDD:304433	81/298 (27%)
mAChR-C	NP_572358.1	7tm_1	67..321	CDD:278431	79/281 (28%)
LOC100007535	XP_001345968.4	7tm_GPCRs	7..293	CDD:333717	82/307 (27%)
		TM helix 1	8..32	CDD:320095	4/23 (17%)
		TM helix 2	41..63	CDD:320095	10/21 (48%)
		TM helix 3	77..99	CDD:320095	8/21 (38%)
		TM helix 4	122..138	CDD:320095	3/15 (20%)
		TM helix 5	172..195	CDD:320095	5/26 (19%)
		TM helix 6	224..249	CDD:320095	9/30 (30%)
		TM helix 7	261..286	CDD:320095	7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D252862at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920