DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nonC and TRA1

DIOPT Version :9

Sequence 1:	NP_001284967.1	Gene:	nonC / 31625	FlyBaseID:	FBgn0263968	Length:	3218	Species:	Drosophila melanogaster
Sequence 2:	NP_011967.1	Gene:	TRA1 / 856499	SGDID:	S000001141	Length:	3744	Species:	Saccharomyces cerevisiae

Alignment Length:	2345	Identity:	406/2345 - (17%)
Similarity:	770/2345 - (32%)	Gaps:	728/2345 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   205 RKSYPIYEEFIVKNY----KSSKRMQKYMIMALRATLSCDTKCELHMYADKIMLLLKDFLENAES 265
            |...|:..:||..::    |:|..::|::...:.|  |.:.:.:.:...|..:.:|.|   ....
Yeast  1738 RDQNPLLLDFIDFSFSNGIKASYSLKKFIFHNIIA--SSNKEKQNNFINDATLFVLSD---KCLD 1797

  Fly   266 ADIFI---VVSNTLVQFAASYAETFECHFTDVVDIVIGWQLEAGQPTDLKTHCAQVLEQLTPFFS 327
            |.||:   |:::||                 :.::.....|::....|.|....::|.......|
Yeast  1798 ARIFVLKNVINSTL-----------------IYEVATSGSLKSYLVEDKKPKWLELLHNKIWKNS 1845

  Fly   328 KQIDFSYGLLDQFVEDITTLE---------EGEPANTAE-------RVGAFVGAFNTLLKCLARM 376
            ..| .:|.:||.  .|:...|         :.:|...||       ....|:...:||:|..|.:
Yeast  1846 NAI-LAYDVLDH--HDLFRFELLQLSAIFIKADPEIIAEIKKDIIKFCWNFIKLEDTLIKQSAYL 1907

  Fly   377 QIFVGMPTCECIVKMAVDHLIKIMPTLHLNTEALVNINELICICLLNNFTGLDPILLEQV----- 436
            .....:...:..:|:.....:.::.:.|:....||.          .:...|.|:|.|::
Yeast  1908 VTSYFISKFDFPIKVVTQVFVALLRSSHVEARYLVK----------QSLDVLTPVLHERMNAAGT 1962

  Fly   437 ---LLDQVKRMISLTELQRQSVLYLLLCTVRRL----RARLTPSLVHFIFQSNPYMTKVRLRSPG 494
               .::.|||::......:.::||..|.:...|    |.....:::|       :|.|:...|..
Yeast  1963 PDTWINWVKRVMVENSSSQNNILYQFLISHPDLFFNSRDLFISNIIH-------HMNKITFMSNS 2020

  Fly   495 ETS--------YKLLLRTCQETLLIRNV---------PLLQQAYKYLVDDIDACLEKLLITAPRS 542
            .:.        ..|:|....:||.|.||         .::....|..::.::|....:::.|..:
Yeast  2021 NSDSHTLAIDLASLILYWENKTLEITNVNNTKTDSDGDVVMSDSKSDINPVEADTTAIIVDANNN 2085

  Fly   543 KARKASVLLVFHLSALAALAKQTSSIIGMYACKPSILELLLTNCRAHELKFWSKYPAAQQAIFGL 607
            ..      :..|      |.:..::.:..|.|        .:|.||.|.:            .||
Yeast  2086 SP------ISLH------LREACTAFLIRYVC--------ASNHRAIETE------------LGL 2118

  Fly   608 LVVHCQANHNFRTNSSLLRDQELSAENTSPTANSFASILRFLDSVLGQAHQLAPQNLRVLLQWIQ 672
            ..::..        |.|:.|:..:  |.:.....|...|.|.|        |..:|
Yeast  2119 RAINIL--------SELISDKHWT--NVNVKLVYFEKFLIFQD--------LDSEN--------- 2156

  Fly   673 MLLRECREKIDLL---MEQENFRGICRNIAATASKLVPLESAACIQTVLDYGLERLEKYPKLLIL 734
             :|..|...:|:|   .:.:....|..|:....:.|     ..||::......|.|:|.  |.::
Yeast  2157 -ILYYCMNALDVLYVFFKNKTKEWIMENLPTIQNLL-----EKCIKSDHHDVQEALQKV--LQVI 2213

  Fly   735 YRDTALQQLQMLSTNYHAPYFQIYAQLPLHLTLTGGESSMPG--MASRRVSVWQQRISQYSAVRD 797
            .:....|.:.::.                       |...||  ......||..|.:.:.|:|..
Yeast  2214 MKAIKAQGVSVII-----------------------EEESPGKTFIQMLTSVITQDLQETSSVTA 2255

  Fly   798 NV------FRDFFDRVQKPEQDSLIHCLRELFVRSCQ-----VAPQDERQMNLSQCTKRCQRLAI 851
            .|      |.:|.|.:.     .|:..|.:.|.:.|:     ..|:|...:..::.|.:.
Yeast  2256 GVTLAWVLFMNFPDNIV-----PLLTPLMKTFSKLCKDHLSISQPKDAMALEEARITTKL----- 2310

  Fly   852 AWLQFEAARYCVDQRLRTTVGKPQETFLGFEAIIMRHARLLSGCAKEIERSALDDLSLEELLSMQ 916
                .|...|.:..:: :.:|..:..||...|:::.|              ::|...|.::::|.
Yeast  2311 ----LEKVLYILSLKV-SLLGDSRRPFLSTVALLIDH--------------SMDQNFLRKIVNMS 2356

  Fly   917 SNLSLLLGFLDALEKLIYNAAEGSAFALRPPEKQVAAF------FRL-NNPTCQSWFNRIRIGVV 974
                         ...|:|.      .:.|..|:.||.      |.: ..|:....|..|
Yeast  2357 -------------RSWIFNT------EIFPTVKEKAAILTKMLAFEIRGEPSLSKLFYEI----- 2397

  Fly   975 IIAM----HVQQPELVIRYAQQILVNSKTQDPTYSQAIVYMAWSLVSCQEADSLRGLRLWARGKS 1035
            ::.:    |....|:.:|..|..||.::.:|....:..:.:   |.:..|.|....|....|.::
Yeast  2398 VLKLFDQEHFNNTEITVRMEQPFLVGTRVEDIGIRKRFMTI---LDNSLERDIKERLYYVIRDQN 2459

  Fly  1036 CK---SYKWLKYAADQAAGKRESALAGYRTILAEKELQSELEPHTRQFVVSQMMQCLQDLGQWSQ 1097
            .:   .|.||..|....          |.:...||||.            .:.:.||.......:
Yeast  2460 WEFIADYPWLNQALQLL----------YGSFNREKELS------------LKNIYCLSPPSILQE 2502

  Fly  1098 LVELKQQQMTRPEDRELNPFLQRSNVEVNALERLLAKSEESCSSMDALGGVFQQ-----LSLWPS 1157
            .:....:.:|...|.||:.|::.....:..|.|::     |...:|:|..:|.|     ...|.:
Yeast  2503 YLPENAEMVTEVNDLELSNFVKGHIASMQGLCRII-----SSDFIDSLIEIFYQDPKAIHRAWVT 2562

  Fly  1158 NWDESVSSSGLSERASFSSIHMRQRTEDIVLHKLLEDRCVPDQAKNLLDTQWRDSLLNPSFDQRS 1222
            .:.:...|...:|:..|      .|:...:|.|....|.:..          |.:::|...|..|
Yeast  2563 LFPQVYKSIPKNEKYGF------VRSIITLLSKPYHTRQISS----------RTNVINMLLDSIS 2611

  Fly  1223 -CKELTLLRHIVQGVSGG-----QELSLL-PVSSGRCQNRSKFISS---AILMRCLAWTQLLRQH 1277
             .:.|.|..|:|:.::..     |.:::| .:.|....:.:|.|.:   |:|.   .:..|..:.
Yeast  2612 KIESLELPPHLVKYLAISYNAWYQSINILESIQSNTSIDNTKIIEANEDALLE---LYVNLQEED 2673

  Fly  1278 CAPGSWETLCLDAAAAAREEGNLQLA-ETLLTQFFGQPIGEIAALFSLEQGVQTDNPEMLRGYSE 1341
            ...|.|.      ..|...|.|:.|: |.:......|.:.|:|.:.:....:.....|.......
Yeast  2674 MFYGLWR------RRAKYTETNIGLSYEQIGLWDKAQQLYEVAQVKARSGALPYSQSEYALWEDN 2732

  Fly  1342 LVKCLHLQQQQSQTHSGDLSSSIDVCAALCLNIQKSNNQPAAGADLLL----NLADW-------- 1394
            .::|....|..            ||...|.        :.....||||    .:|||
Yeast  2733 WIQCAEKLQHW------------DVLTELA--------KHEGFTDLLLECGWRVADWNSDRDALE 2777

  Fly  1395 IAVRTCNGLTTNQSPVLIQLL-----------DQLPECPLTCDS----------SQPLAIPQAER 1438
            .:|::...:.|.:..:....|           ||  |....||.          |.|:....|.:
Yeast  2778 QSVKSVMDVPTPRRQMFKTFLALQNFAESRKGDQ--EVRKLCDEGIQLSLIKWVSLPIRYTPAHK 2840

  Fly  1439 MVARLVHSCLQQRPNYAEALIAYGNWCYRWGKKVADSCCVLTQADATAISQALDIPQPLES--EK 1501
            .   |:|. .||...:.||...|.|              :.|.......|:|.:|.:.|::  ::
Yeast  2841 W---LLHG-FQQYMEFLEATQIYAN--------------LHTTTVQNLDSKAQEIKRILQAWRDR 2887

  Fly  1502 LDE----------------------------LLQALSTEQPPAN--------------CVEVCPD 1524
            |..                            |:.||......:|              .:.....
Yeast  2888 LPNTWDDVNMWNDLVTWRQHAFQVINNAYLPLIPALQQSNSNSNINTHAYRGYHEIAWVINRFAH 2952

  Fly  1525 AARARD-DEAAKNRLRRLTFLADKTPEALDAILQIWRRA----------------IANT------ 1566
            .||..: .:...::|.|:..|.:  .|..:|.|::..:|                |:||
Yeast  2953 VARKHNMPDVCISQLARIYTLPN--IEIQEAFLKLREQAKCHYQNMNELTTGLDVISNTNLVYFG 3015

  Fly  1567 --------------------YDYYKDA-----------ARSYFQYLSFKSGSGPEKPEGEGVVSQ 1600
                                |:....|           |:::.|:..|......|:|......|.
Yeast  3016 TVQKAEFFTLKGMFLSKLRAYEEANQAFATAVQIDLNLAKAWAQWGFFNDRRLSEEPNNISFASN 3080

  Fly  1601 RERLHVDDSNLVTTT------LRLLRLI-VKHASG-LQEVLEQGLHTTPIAPWKVIIPQLFSRLN 1657
            ....::..:.|...:      .|:|.|| :..||| |....:......|:..|...||||.:.|:
Yeast  3081 AISCYLQAAGLYKNSKIRELLCRILWLISIDDASGMLTNAFDSFRGEIPVWYWITFIPQLLTSLS 3145

  Fly  1658 HHEPYVRKSVCDLLCRLAKSRPQLVIFPAVVGANREQQDATAPPATARPTTEDACCYGYLLGELS 1722
            |.|   ...|..:|.|:|||.||.:.|                  ..|.|.||
Yeast  3146 HKE---ANMVRHILIRIAKSYPQALHF------------------QLRTTKED------------ 3177

  Fly  1723 KQAPEAVQHVKLMVKELRRVCLLWDEYWIHSLAHIYNTYVSRVSALATDFRPDDHEGKNNRFNVW 1787
                       ..|.:.:.:.::.|                         :||.:: :|.|...|
Yeast  3178 -----------FAVIQRQTMAVMGD-------------------------KPDTND-RNGRRQPW 3205

  Fly  1788 R-------------PQLLADLEALVA-VTSRPPETTYERSFRKRFDAPIRLTVDALRHRRYPEAW 1838
            .             |.|...||:||| :..|...||.|..||.   ..:.|....|.:.|.|..
Yeast  3206 EYLQELNNILKTAYPLLALSLESLVAQINDRFKSTTDEDLFRL---INVLLIDGTLNYNRLPFP- 3266

  Fly  1839 DKLKQLYHILQSNMIRGSGSTLKMQSISPVLCG------------IGRMR--------------- 1876
            .|..:|....:.|:::.| :||....|.|....            |.|:|
Yeast  3267 RKNPKLPENTEKNLVKFS-TTLLAPYIRPKFNADFIDNKPDYETYIKRLRYWRRRLENKLDRASK 3330

  Fly  1877 ---------------------ISMPGLDAHGPDGDQVYIESVESSVCVLP-------TKTKPKKV 1913
                                 |.:||......|.:..:|:...    .||       |.:..:::
Yeast  3331 KENLEVLCPHLSNFHHQKFEDIEIPGQYLLNKDNNVHFIKIAR----FLPTVDFVRGTHSSYRRL 3391

  Fly  1914 AFYGSNGQRYTFL--FKGMEDLHLDERIMQFLSISNAIMACRSDAPGNGCYRAHHYSV---IPLG 1973
            ...|.:|..::|.  :..:.....:||:.|...:.|..::...:..    .|:..:::   |||.
Yeast  3392 MIRGHDGSVHSFAVQYPAVRHSRREERMFQLYRLFNKSLSKNVETR----RRSIQFNLPIAIPLS 3452

  Fly  1974 PQSGLISWVDGVTPVFALYKKWQQRRSQVAGNAGAGAVANVPRRFTDLFYNKLSPLLAKHNMQVS 2038
            ||..:::.....|.:..::.::.:::            ...|....|...:||:   |.|:..:.
Yeast  3453 PQVRIMNDSVSFTTLHEIHNEFCKKK------------GFDPDDIQDFMADKLN---AAHDDALP 3502

  Fly  2039 DPRRQWPISVL-LQVLDEL-SQETPNDLLA---RELWCQAGNAAEWRQSVRRFVRCMSVMSMIGY 2098
            .|    .:::| :::.:.: :...|:::|.   ..|:.|..:...:|   ::|....|....:.|
Yeast  3503 AP----DMTILKVEIFNSIQTMFVPSNVLKDHFTSLFTQFEDFWLFR---KQFASQYSSFVFMSY 3560

  Fly  2099 VIGLGDRHLDNVLINLGSGDIVHIDY---NVCFE------KGRTLRIP---------EKVPFRLT 2145
            ::.:.:|....:.::..||::..::.   ...:|      |...|.:|         |.||||||
Yeast  3561 MMMINNRTPHKIHVDKTSGNVFTLEMLPSRFPYERVKPLLKNHDLSLPPDSPIFHNNEPVPFRLT 3625

  Fly  2146 QNLVQAMGITGIEGPFRLGCEYVLKVMRKERETLLTLLEAFVYDPLVDWTTNDDAQALRRSL--N 2208
            .|:...:|.:.:||.|.:....:.:.:.:....|.|.|..|:.|.::.|.:|     |.|.:  |
Yeast  3626 PNIQSLIGDSALEGIFAVNLFTISRALIEPDNELNTYLALFIRDEIISWFSN-----LHRPIIEN 3685

  Fly  2209 AKLQE 2213
            .:|:|
Yeast  3686 PQLRE 3690

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nonC	NP_001284967.1	SMG1	571..1140	CDD:292413	102/598 (17%)
		Rapamycin_bind	1738..1845	CDD:285924	24/120 (20%)
		PIKKc_SMG1	1894..2196	CDD:270714	59/336 (18%)
		FATC	3189..3217	CDD:280430
TRA1	NP_011967.1	TEL1	1232..3744	CDD:227365	406/2345 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900