DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nonC and PIK1

DIOPT Version :9

Sequence 1:	NP_001284967.1	Gene:	nonC / 31625	FlyBaseID:	FBgn0263968	Length:	3218	Species:	Drosophila melanogaster
Sequence 2:	NP_014132.1	Gene:	PIK1 / 855454	SGDID:	S000005211	Length:	1066	Species:	Saccharomyces cerevisiae

Alignment Length:	1128	Identity:	211/1128 - (18%)
Similarity:	384/1128 - (34%)	Gaps:	293/1128 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  1257 KFISSA--ILMRCLAWTQLLRQHCAP-GSWETLCLDAAAAAREEGNL---QLAETLLTQFFGQPI 1315
            |.|:|:  .|..|:   :||.:|... |....||...|.....|...   ||.:.|:|.     .
Yeast    25 KLINSSEFTLHNCV---ELLCKHSENIGIHYYLCQKLATFPHSELQFYIPQLVQVLVTM-----E 81

  Fly  1316 GEIAALFSLEQGVQTDNPEMLRGYSELVKCLHLQQQQSQTHSGDLSSSIDVCAALCLNIQKSNNQ 1380
            .|..||..|...::.:||     :..|:....||...:...:...|....|...:..|:|.:...
Yeast    82 TESMALEDLLLRLRAENP-----HFALLTFWQLQALLTDLSTDPASYGFQVARRVLNNLQTNLFN 141

  Fly  1381 PAAGADLLLNLADWIAVRTCNGLTTNQSPVLI--QLLDQLPECPLTCDSSQPLAIPQAER---MV 1440
            .::|:|..:.:.:            |.:|.|:  .::......|...:.::||...|..|   .|
Yeast   142 TSSGSDKNVKIHE------------NVAPALVLSSMIMSAIAFPQLSEVTKPLVESQGRRQKAFV 194

  Fly  1441 ARLVHSCLQ---QRPNYAEALIAYGNWCYRWGKKVADSCCVLTQADATAISQALDIPQPLESEKL 1502
            .:|..|.::   :.......|:         .||.:.|..|.:...:|..| .:|:..|:::::.
Yeast   195 FKLARSAMKDFTKNMTLKNTLL---------NKKTSRSKRVSSNRSSTPTS-PIDLIDPIKTKED 249

  Fly  1503 DELLQALSTEQPPANCVEVCPDAARARDDEAAKNRLRRLTFLADKTPEALDAILQIWRRAIANTY 1567
            ....::..:|      |::..|......::..:.|:.....|..:.|:.||      ...:..||
Yeast   250 ASFRKSRHSE------VKLDFDIVDDIGNQVFEERISSSIKLPKRKPKYLD------NSYVHRTY 302

  Fly  1568 D---YYKDAARSYF---------QYLSFKS--------GSGPEKPEGE-----------GVVSQR 1601
            |   ..:|.:.|..         .|:|.|.        |:..::..||           ...|..
Yeast   303 DGKNINRDGSISNTAKALDGNKGDYISPKGRNDENNEIGNNEDETGGETEEDADALNSDHFTSSM 367

  Fly  1602 ERLH----------------------------------------------VDDSNLVTTT-LRLL 1619
            ..||                                              :|.|.|.||: :::|
Yeast   368 PDLHNIQPRTSSASSASLEGTPKLNRTNSQPLSRQAFKNSKKANSSLSQEIDLSQLSTTSKIKML 432

  Fly  1620 -----RLIVKHASGLQEVLEQGLHTTPI-----------------APWKVIIPQLFSRLNHHEPY 1662
                 |...:.|..| |.:.|.|...|.                 .|.:|.||.|.       |.
Yeast   433 KANYFRCETQFAIAL-ETISQRLARVPTEARLSALRAELFLLNRDLPAEVDIPTLL-------PP 489

  Fly  1663 VRKSVCDLLCRLAKSRPQL------VIFPAVVGANREQQDATAPPATARPTTEDACCYGYLLGEL 1721
            .:|.....|..:..:..|:      |.:..::...|::.|..       ||:|   ....||.::
Yeast   490 NKKGKLHKLVTITANEAQVLNSAEKVPYLLLIEYLRDEFDFD-------PTSE---TNERLLKKI 544

  Fly  1722 SKQAPEAVQHVKLMVK----ELRRVCLLWDEYWIHSL--AHIYNTYVSRVSALATDFRPDDHEGK 1780
            |......:..:..|.:    |.|....|.......|:  ::.:|...||...|::..|.|.....
Yeast   545 SGNQGGLIFDLNYMNRKENNENRNESTLTSNNTRSSVYDSNSFNNGASRNEGLSSTSRSDSASTA 609

  Fly  1781 NNRFNVWRPQLLADLEALVAVTSRPPETTYERSFRKRFDAPIRLTVDALRHRRYPEAWDKLKQLY 1845
            :.|..|.:.:.|.|: ::|.|.:|..:..|..:...:..|.:.:..|..:.|. ||. :....|.
Yeast   610 HVRTEVNKEEDLGDM-SMVKVRNRTDDEAYRNALVIQSAANVPILPDDSQDRS-PEL-NFGSNLD 671

  Fly  1846 HILQSNMIRGSGSTLKMQSISPVLCGIGRMRISMPGLDAHGPDGDQVYIESVESSVCVLPTKTKP 1910
            .:|..|.|.......:..:::      .:||:|            .|.:..::.|...|...||.
Yeast   672 EVLIENGINSKNIHSQTDALA------DQMRVS------------AVMLAQLDKSPQQLSESTKQ 718

  Fly  1911 ---------KKV----------AFYGSNGQR---YTFLFKGMEDLHLDE----------RIMQFL 1943
                     |:|          |.:|..|:|   ...:..|::..:|.|          :..::.
Yeast   719 IRAQIISSMKEVQDKFGYHDLEALHGMAGERKLENDLMTGGIDTSYLGEDWATKKERIRKTSEYG 783

  Fly  1944 SISN----AIMACRSDAPGNGCYRAHHYSVIPLGPQSGLISWVDGVTPVFALYKKWQQRRSQVAG 2004
            ...|    :::|...|   :....|..|.:|    |:....||.....|      |.:|...:..
Yeast   784 HFENWDLCSVIAKTGD---DLRQEAFAYQMI----QAMANIWVKEKVDV------WVKRMKILIT 835

  Fly  2005 NAGAGAVANVPRRFTDLFYNKLSPLLAKHNMQVSDPRRQWPISVLLQVLDELSQETPNDLLAREL 2069
            :|..|.|..:....:   .:.:...|.|..::.::...:..|:.|            ||...|..
Yeast   836 SANTGLVETITNAMS---VHSIKKALTKKMIEDAELDDKGGIASL------------NDHFLRAF 885

  Fly  2070 WCQAG--NAAEWRQSVRRFVRCMSVMSMIGYVIGLGDRHLDNVLINLGSGDIVHIDYNVCFEKGR 2132
                |  |..::|::...|...::..|:|.|::.:.|||..|::|: ..|.:.|||:........
Yeast   886 ----GNPNGFKYRRAQDNFASSLAAYSVICYLLQVKDRHNGNIMID-NEGHVSHIDFGFMLSNSP 945

  Fly  2133 TLRIPEKVPFRLTQNLVQAMGITGIEG-PFRLGCEYV---LKVMRKERETLLTLLEAFVYD---P 2190
            .....|..||:||...::.:|  |:|| .|:...|..   .|.:||..:.::::.|....|   |
Yeast   946 GSVGFEAAPFKLTYEYIELLG--GVEGEAFKKFVELTKSSFKALRKYADQIVSMCEIMQKDNMQP 1008

  Fly  2191 LVDWTTNDDAQALRRSLNAKLQE 2213
            ..|.......| ||:.....|.|
Yeast  1009 CFDAGEQTSVQ-LRQRFQLDLSE 1030

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nonC	NP_001284967.1	SMG1	571..1140	CDD:292413
		Rapamycin_bind	1738..1845	CDD:285924	23/108 (21%)
		PIKKc_SMG1	1894..2196	CDD:270714	69/346 (20%)
		FATC	3189..3217	CDD:280430
PIK1	NP_014132.1	TEL1	<1..1066	CDD:227365	211/1128 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900