Protein Alignment nonC and TOR2

DIOPT Version :10

• Sequence 1: NP_727132.1
• Gene: nonC / 31625
• FlyBaseID: FBgn0263968
• Length: 3218
• Species: Drosophila melanogaster
• Sequence 2: NP_012719.2
• Gene: TOR2 / 853632
• SGDID: S000001686
• Length: 2474
• Species: Saccharomyces cerevisiae
• Alignment Length: 2538
• Identity: 515/2538 - (20%)
• Similarity: 881/2538 - (34%)
• Gaps: 855/2538 - (33%)

  Fly   164 MGYMTC----SFVWILD-NMLTLYKQCPP---------------PVLEEC--SKTLGLIG----- 201
            :|.:.|    :|...|: ::|.|...||.               |.||..  |:.|.|:.
Yeast   465 IGKLACALGPAFAKHLNKDLLNLMLNCPMSDHMQETLMILNEKIPSLESTVNSRILNLLSISLSG 529

  Fly   202 --FINRKSYPIYEEFIVKNYKSSKRMQKYM---------IMALRATLSCDTKCEL--HMYA--DK 251
              ||....|....:|.::..:.| |.|.:|         |...:..:.|....:|  |.|:  :.
Yeast   530 EKFIQSNQYDFNNQFSIEKARKS-RNQSFMKKTGESNDDITDAQILIQCFKMLQLIHHQYSLTEF 593

  Fly   252 IMLLLKDFLENAESA----------DIFI---VVSNTLVQFAASYAETF-ECHFTDVVDIVIGWQ 302
            :.|:...::|:.:|:          |:||   :...|.|....|.:|.. :.....:.|.|...:
Yeast   594 VRLITISYIEHEDSSVRKLAALTSCDLFIKDDICKQTSVHALHSVSEVLSKLLMIAITDPVAEIR 658

  Fly   303 LEAGQPTDLKTHCAQVLEQLTPFFSKQI--------------DFSYGLLDQFVEDITTLEEGEPA 353
            ||             :|:.|...|..|:              |..:|:..:.::.|..|....||
Yeast   659 LE-------------ILQHLGSNFDPQLAQPDNLRLLFMALNDEIFGIQLEAIKIIGRLSSVNPA 710

  Fly   354 NTAERVGAFVGAFNTLLKCLARMQIFVGMP-------TCECIVKMAVDHLIKIMPTLHLNTEALV 411
            .....:.      .|||:.|.::: |..||       |..|.:..:.|.:.|
Yeast   711 YVVPSLR------KTLLELLTQLK-FSNMPKKKEESATLLCTLINSSDEVAK------------- 755

  Fly   412 NINELICICLLNNFTGLDPILLEQVLLDQVKRMISLTELQRQSVLYLLLCT----VRRLRARLTP 472
                          ..:||||  .|:|.:.:...|........||..|...    :.|....|.|
Yeast   756 --------------PYIDPIL--DVILPKCQDASSAVASTALKVLGELSVVGGKEMTRYLKELMP 804

  Fly   473 SLVH-FIFQSNPYMTKVRLRSPGE----TSYKLLLRTCQETLLIRNVPLLQQAYKYLVDDIDACL 532
            .::: |..|||.:.....|.:.|:    :.|.:             .|||.  |..|:    ..|
Yeast   805 LIINTFQDQSNSFKRDAALTTLGQLAASSGYVV-------------GPLLD--YPELL----GIL 850

  Fly   533 EKLLITAPRSKARKASVLLVFHLSAL-------AALAKQTSSIIGMYACKPSI-LELLLTNCRAH 589
            ..:|.|......|:.:|.|:..|.||       ..:...:.|.:...|  ||| :.||:......
Yeast   851 INILKTENNPHIRRGTVRLIGILGALDPYKHREIEVTSNSKSSVEQNA--PSIDIALLMQGVSPS 913

  Fly   590 ELKFWSKYPAAQQAIFGLLVVHCQANHNFRTNSSLLRDQELSAENTSPT-------ANSFASILR 647
            ..::   ||.        :|:|        ....:|.|..||..:|:..       .|.....:.
Yeast   914 NDEY---YPT--------VVIH--------NLMKILNDPSLSIHHTAAIQAIMHIFQNLGLRCVS 959

  Fly   648 FLDSV----------------------LGQAHQLAPQNLRVLLQWIQMLLRE------------- 677
            |||.:                      ||....:..|::|..::.|..::||
Yeast   960 FLDQIIPGIILVMRSCPPSQLDFYFQQLGSLISIVKQHIRPHVEKIYGVIREFFPIIKLQITIIS 1024

  Fly   678 CREKIDLLMEQENFRGICRNIA---------ATASKLVPLESAACIQTVLDYGLERLEKYPKLL- 732
            ..|.|...:|.|..|.:...:.         .:..::||:.   .:::::.:| ..||.|..|:
Yeast  1025 VIESISKALEGEFKRFVPETLTFFLDILENDQSNKRIVPIR---ILKSLVTFG-PNLEDYSHLIM 1085

  Fly   733 -ILYRDT-----ALQQLQM-----LSTNYHAPYFQIYAQLPLHLTLTGGESSMPGMASRRVSVWQ 786
             |:.|.|     :|:::.:     |:.|.:...........|...|..|:..:.......:|:..
Yeast  1086 PIVVRMTEYSAGSLKKISIITLGRLAKNINLSEMSSRIVQALVRILNNGDRELTKATMNTLSLLL 1150

  Fly   787 QRISQYSAVRDNVFRDFF--DRVQKPEQDSLIH------CL--RELFVRSCQVAPQD--ERQMNL 839
            .::.....|...|.....  :|:|....|.|::      ||  ..:|.:..:|..:.  |.:|.:
Yeast  1151 LQLGTDFVVFVPVINKALLRNRIQHSVYDQLVNKLLNNECLPTNIIFDKENEVPERKNYEDEMQV 1215

  Fly   840 SQCTKRCQRLAIAWLQFEAARYCVDQR-------------LRTTVGKPQETFLGFEAIIMRH--- 888
            ::.......|..||       ||..|:             ::.....|........:::..:
Yeast  1216 TKLPVNQNILKNAW-------YCSQQKTKEDWQEWIRRLSIQLLKESPSACLRSCSSLVSVYYPL 1273

  Fly   889 ARLL-----SGCAKEIERSALDDL--SLEELLSMQSN----LSLLLGFLDALE------------ 930
            ||.|     |.|..|::.|..:||  :|.:.||...|    ..:||..::.:|
Yeast  1274 ARELFNASFSSCWVELQTSYQEDLIQALCKALSSSENPPEIYQMLLNLVEFMEHDDKPLPIPIHT 1338

  Fly   931 -------------KLIYNAAEGSAFALRPPEKQVAAFFRLNNPTCQSWFNRIRIGVVIIAMHVQQ 982
                         .|.|...|   |...|....:.|...:||...|:   ...||
Yeast  1339 LGKYAQKCHAFAKALHYKEVE---FLEEPKNSTIEALISINNQLHQT---DSAIG---------- 1387

  Fly   983 PELVIRYAQQILVNSKTQDPTYSQAIVYMAWSLVSCQEADSLRGLRLWARGKSCKSYKWLKYAAD 1047
               ::::|||                            .:.|:....|..    |..:|
Yeast  1388 ---ILKHAQQ----------------------------HNELQLKETWYE----KLQRW------ 1411

  Fly  1048 QAAGKRESALAGYRTILAEKELQSE--LEPHTRQFVVSQMMQCLQDLGQWSQLVELKQQQ--MTR 1108
                  |.|||.|.    |||...|  :|      |:...::.|..||:|.:|.:|..::  ..:
Yeast  1412 ------EDALAAYN----EKEAAGEDSVE------VMMGKLRSLYALGEWEELSKLASEKWGTAK 1460

  Fly  1109 PEDRELNPFLQRSNVEVNALERLLAKSEESCSSMDALGGVFQQLSLWPSNWDESVSSSGLSERAS 1173
            ||.::             |:..|.|         .|..|:.|        |||.         |.
Yeast  1461 PEVKK-------------AMAPLAA---------GAAWGLEQ--------WDEI---------AQ 1486

  Fly  1174 FSSIHMRQRTED-------IVLH----KLLEDRCVPDQAKNLLDTQWRDSLLNPSFDQRSCKELT 1227
            ::|: |:.::.|       :.||    |..|....  .|::||.|: ..:|:|.|:::  ...:.
Yeast  1487 YTSV-MKSQSPDKEFYDAILCLHRNNFKKAEVHIF--NARDLLVTE-LSALVNESYNR--AYNVV 1545

  Fly  1228 LLRHIVQGVSGGQELSLLPVSSGRCQNRSKFIS-----SAILMRCL----AWTQLLRQH---CAP 1280
            :...|:..:....:...||      ||..|.::     :..|:.|.    .|.::||..   ..|
Yeast  1546 VRAQIIAELEEIIKYKKLP------QNSDKRLTMRETWNTRLLGCQKNIDVWQRILRVRSLVIKP 1604

  Fly  1281 GSWETLCLDAAAAAREEGNLQLAETLLTQFFGQPIGEIAALFSLEQGVQTDNPEMLRGYSELVKC 1345
            .....:.:..|...|:.|.:.||:.:|...             ||   :||:|:
Yeast  1605 KEDAQVRIKFANLCRKSGRMALAKKVLNTL-------------LE---ETDDPD----------- 1642

  Fly  1346 LHLQQQQSQTHSGDLSSSIDVCAALCLNIQKSNNQPAAGADLLLNLADWIAVRTCNGLTTNQSPV 1410
                      |.....:|..|..|....:..:..|..| ...|:|...    |..:.|..:.:.:
Yeast  1643 ----------HPNTAKASPPVVYAQLKYLWATGLQDEA-LKQLINFTS----RMAHDLGLDPNNM 1692

  Fly  1411 LIQLLDQLPECPLTCDSSQPLAIPQAERMVARLVHSCLQQRPNYAEALIAYGNW--CY--RWGKK 1471
            :.|                  ::||..:.|.|.|....:.   .|...:..|.|  |.  :|...
Yeast  1693 IAQ------------------SVPQQSKRVPRHVEDYTKL---LARCFLKQGEWRVCLQPKWRLS 1736

  Fly  1472 VADSC----CVLTQADATAISQALDIPQPLESEKLDELLQALSTEQPPANCVEVCPDAARARDDE 1532
            ..||.    .:.|..|.|......:  ..|.:.::..:|.::|.::...:      ||:...|..
Yeast  1737 NPDSILGSYLLATHFDNTWYKAWHN--WALANFEVISMLTSVSKKKQEGS------DASSVTDIN 1793

  Fly  1533 AAKNRLRRLTFLADKTPEALDAILQIWRRAIANTYD----YYKD---------AARSYFQYLSFK 1584
            ...|.:..:                       ||:|    :|..         |.:.:|..:|
Yeast  1794 EFDNGMIGV-----------------------NTFDAKEVHYSSNLIHRHVIPAIKGFFHSIS-- 1833

  Fly  1585 SGSGPEKPEGEGVVSQRERLHVDDSNLVTTTLRLLRLIVKHASGLQE---VLEQGLHTTPIAPWK 1646
                                 :.:|:.:...||||.|.... .|:.|   .:.:|.:...|..|.
Yeast  1834 ---------------------LSESSSLQDALRLLTLWFTF-GGIPEATQAMHEGFNLIQIGTWL 1876

  Fly  1647 VIIPQLFSRLNHHEPYVRKSVCDLLCRLAKSRPQLVIFPAVVGANRE---QQDATAPPATARPTT 1708
            .::|||.||::.....|.:|:..||..|.|:.||.:::|.:|....|   :|.|...
Yeast  1877 EVLPQLISRIHQPNQIVSRSLLSLLSDLGKAHPQALVYPLMVAIKSESLSRQKAALS-------- 1933

  Fly  1709 EDACCYGYLLGELSKQAPEAVQHVKLMVKELRRVCLLWDEYWIHSLAHIYNTYVSRVSALATDFR 1773
                    ::.::...:|..|...:|:..||.|:.:||.|.|...|
Yeast  1934 --------IIEKMRIHSPVLVDQAELVSHELIRMAVLWHEQWYEGL------------------- 1971

  Fly  1774 PDDHE----GKNNRFNVWRPQLLADLEALVAVTSRPPETTYERSFRKRFDAPIRLTVDALRHRR- 1833
             ||..    |::|     ..::.|.||.|..:..|.|||..|.||:..|...:....:.|.:.:
Yeast  1972 -DDASRQFFGEHN-----TEKMFAALEPLYEMLKRGPETLREISFQNSFGRDLNDAYEWLMNYKK 2030

  Fly  1834 ------YPEAWDKLKQLYHILQSNMIRGSG------STLKMQSISPVLCGIGRMRISMPGLDAHG 1886
                  ..:|||    :|:    |:.|..|      .||::|.:||.|.....:.:::||..|.|
Yeast  2031 SKDVSNLNQAWD----IYY----NVFRKIGKQLPQLQTLELQHVSPKLLSAHDLELAVPGTRASG 2087

  Fly  1887 PDGDQ-VYIESVESSVCVLPTKTKPKKVAFYGSNGQRYTFLFKGMEDLHLDERIMQFLSISNAIM 1950
              |.. |.|...|....|:.:|.:|:|....||:|:.|.::.||.||:..|..:||...:.|.::
Yeast  2088 --GKPIVKISKFEPVFSVISSKQRPRKFCIKGSDGKDYKYVLKGHEDIRQDSLVMQLFGLVNTLL 2150

  Fly  1951 ACRSDAPGNGCYRAH----HYSVIPLGPQSGLISWVDGVTPVFALYKKWQQRRSQVAGNAGAGAV 2011
              ::||.   |:|.|    .|..|||.|:|||:.||........|.::.::.
Yeast  2151 --QNDAE---CFRRHLDIQQYPAIPLSPKSGLLGWVPNSDTFHVLIREHREA------------- 2197

  Fly  2012 ANVPRRFTDLFYNKLSPLLAKHNMQVSDPRRQWPISVLLQV---LDELS------------QETP 2061
                         |..||..:|          |   |:||:   .|.|:            ..|.
Yeast  2198 -------------KKIPLNIEH----------W---VMLQMAPDYDNLTLLQKVEVFTYALNNTE 2236

  Fly  2062 NDLLARELWCQAGNAAEWRQSVRRFVRCMSVMSMIGYVIGLGDRHLDNVLINLGSGDIVHIDYNV 2126
            ...|.:.||.::.::..|.:....:.|.::||||.||::||||||..|::::..:|.::|||:..
Yeast  2237 GQDLYKVLWLKSRSSETWLERRTTYTRSLAVMSMTGYILGLGDRHPSNLMLDRITGKVIHIDFGD 2301

  Fly  2127 CFEKGRTLR--IPEKVPFRLTQNLVQAMGITGIEGPFRLGCEYVLKVMRKERETLLTLLEAFVYD 2189
            ||| ...||  .|||||||||:.|..||.::||||.||:.||.|:||:|..:.:|:.:||||.:|
Yeast  2302 CFE-AAILREKFPEKVPFRLTRMLTYAMEVSGIEGSFRITCENVMKVLRDNKGSLMAILEAFAFD 2365

  Fly  2190 PLVDWTTNDDAQALRRSLNAKLQESADGGGAGGLGVGDLKYHKKDKNKGKPLDSDVKRQPFLSKL 2254
            ||::|                           |.   ||...|.::..|..|       |.:
Yeast  2366 PLINW---------------------------GF---DLPTKKIEEETGIQL-------PVM--- 2390

  Fly  2255 GMLQKYWSTNKTELMPQLEEMEQEVGNLQAAQAKQVVAEEELVKLNQRSALIAEIKSLGTAIESH 2319
                     |..||:                 :...:.|||:.::....
Yeast  2391 ---------NANELL-----------------SNGAITEEEVQRVENEH---------------- 2413

  Fly  2320 SFNTASLRNAVRRGHSEALALLSTERLPDFGRVQCILRSYGQCLQLYHLLDLQGQLVKL-QMESN 2383
                   :||:|    .|.|:|..:|:.|        :..|..::.::.||:..|:.|| |..::
Yeast  2414 -------KNAIR----NARAMLVLKRITD--------KLTGNDIRRFNDLDVPEQVDKLIQQATS 2459

  Fly  2384 SEN 2386
            .||
Yeast  2460 VEN 2462

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nonC	NP_727132.1	SMG1	571..1140	CDD:464869	123/700 (18%)
		PIKKc_SMG1	1894..2196	CDD:270714	105/322 (33%)
		FATC	3189..3217	CDD:460514
TOR2	NP_012719.2	TEL1	290..2474	CDD:227365	515/2538 (20%)
		HEAT repeat	599..620	CDD:293787	2/20 (10%)
		HEAT repeat	642..667	CDD:293787	6/37 (16%)
		HEAT repeat	677..707	CDD:293787	4/29 (14%)
		HEAT repeat	715..748	CDD:293787	9/39 (23%)
		HEAT repeat	758..787	CDD:293787	9/30 (30%)
		HEAT repeat	801..828	CDD:293787	7/26 (27%)
		HEAT repeat	843..873	CDD:293787	8/33 (24%)