DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment nonC and TOR2

DIOPT Version :9

Sequence 1:NP_001284967.1 Gene:nonC / 31625 FlyBaseID:FBgn0263968 Length:3218 Species:Drosophila melanogaster
Sequence 2:NP_012719.2 Gene:TOR2 / 853632 SGDID:S000001686 Length:2474 Species:Saccharomyces cerevisiae


Alignment Length:2538 Identity:515/2538 - (20%)
Similarity:881/2538 - (34%) Gaps:855/2538 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   164 MGYMTC----SFVWILD-NMLTLYKQCPP---------------PVLEEC--SKTLGLIG----- 201
            :|.:.|    :|...|: ::|.|...||.               |.||..  |:.|.|:.     
Yeast   465 IGKLACALGPAFAKHLNKDLLNLMLNCPMSDHMQETLMILNEKIPSLESTVNSRILNLLSISLSG 529

  Fly   202 --FINRKSYPIYEEFIVKNYKSSKRMQKYM---------IMALRATLSCDTKCEL--HMYA--DK 251
              ||....|....:|.::..:.| |.|.:|         |...:..:.|....:|  |.|:  :.
Yeast   530 EKFIQSNQYDFNNQFSIEKARKS-RNQSFMKKTGESNDDITDAQILIQCFKMLQLIHHQYSLTEF 593

  Fly   252 IMLLLKDFLENAESA----------DIFI---VVSNTLVQFAASYAETF-ECHFTDVVDIVIGWQ 302
            :.|:...::|:.:|:          |:||   :...|.|....|.:|.. :.....:.|.|...:
Yeast   594 VRLITISYIEHEDSSVRKLAALTSCDLFIKDDICKQTSVHALHSVSEVLSKLLMIAITDPVAEIR 658

  Fly   303 LEAGQPTDLKTHCAQVLEQLTPFFSKQI--------------DFSYGLLDQFVEDITTLEEGEPA 353
            ||             :|:.|...|..|:              |..:|:..:.::.|..|....||
Yeast   659 LE-------------ILQHLGSNFDPQLAQPDNLRLLFMALNDEIFGIQLEAIKIIGRLSSVNPA 710

  Fly   354 NTAERVGAFVGAFNTLLKCLARMQIFVGMP-------TCECIVKMAVDHLIKIMPTLHLNTEALV 411
            .....:.      .|||:.|.::: |..||       |..|.:..:.|.:.|             
Yeast   711 YVVPSLR------KTLLELLTQLK-FSNMPKKKEESATLLCTLINSSDEVAK------------- 755

  Fly   412 NINELICICLLNNFTGLDPILLEQVLLDQVKRMISLTELQRQSVLYLLLCT----VRRLRARLTP 472
                          ..:||||  .|:|.:.:...|........||..|...    :.|....|.|
Yeast   756 --------------PYIDPIL--DVILPKCQDASSAVASTALKVLGELSVVGGKEMTRYLKELMP 804

  Fly   473 SLVH-FIFQSNPYMTKVRLRSPGE----TSYKLLLRTCQETLLIRNVPLLQQAYKYLVDDIDACL 532
            .::: |..|||.:.....|.:.|:    :.|.:             .|||.  |..|:    ..|
Yeast   805 LIINTFQDQSNSFKRDAALTTLGQLAASSGYVV-------------GPLLD--YPELL----GIL 850

  Fly   533 EKLLITAPRSKARKASVLLVFHLSAL-------AALAKQTSSIIGMYACKPSI-LELLLTNCRAH 589
            ..:|.|......|:.:|.|:..|.||       ..:...:.|.:...|  ||| :.||:......
Yeast   851 INILKTENNPHIRRGTVRLIGILGALDPYKHREIEVTSNSKSSVEQNA--PSIDIALLMQGVSPS 913

  Fly   590 ELKFWSKYPAAQQAIFGLLVVHCQANHNFRTNSSLLRDQELSAENTSPT-------ANSFASILR 647
            ..::   ||.        :|:|        ....:|.|..||..:|:..       .|.....:.
Yeast   914 NDEY---YPT--------VVIH--------NLMKILNDPSLSIHHTAAIQAIMHIFQNLGLRCVS 959

  Fly   648 FLDSV----------------------LGQAHQLAPQNLRVLLQWIQMLLRE------------- 677
            |||.:                      ||....:..|::|..::.|..::||             
Yeast   960 FLDQIIPGIILVMRSCPPSQLDFYFQQLGSLISIVKQHIRPHVEKIYGVIREFFPIIKLQITIIS 1024

  Fly   678 CREKIDLLMEQENFRGICRNIA---------ATASKLVPLESAACIQTVLDYGLERLEKYPKLL- 732
            ..|.|...:|.|..|.:...:.         .:..::||:.   .:::::.:| ..||.|..|: 
Yeast  1025 VIESISKALEGEFKRFVPETLTFFLDILENDQSNKRIVPIR---ILKSLVTFG-PNLEDYSHLIM 1085

  Fly   733 -ILYRDT-----ALQQLQM-----LSTNYHAPYFQIYAQLPLHLTLTGGESSMPGMASRRVSVWQ 786
             |:.|.|     :|:::.:     |:.|.:...........|...|..|:..:.......:|:..
Yeast  1086 PIVVRMTEYSAGSLKKISIITLGRLAKNINLSEMSSRIVQALVRILNNGDRELTKATMNTLSLLL 1150

  Fly   787 QRISQYSAVRDNVFRDFF--DRVQKPEQDSLIH------CL--RELFVRSCQVAPQD--ERQMNL 839
            .::.....|...|.....  :|:|....|.|::      ||  ..:|.:..:|..:.  |.:|.:
Yeast  1151 LQLGTDFVVFVPVINKALLRNRIQHSVYDQLVNKLLNNECLPTNIIFDKENEVPERKNYEDEMQV 1215

  Fly   840 SQCTKRCQRLAIAWLQFEAARYCVDQR-------------LRTTVGKPQETFLGFEAIIMRH--- 888
            ::.......|..||       ||..|:             ::.....|........:::..:   
Yeast  1216 TKLPVNQNILKNAW-------YCSQQKTKEDWQEWIRRLSIQLLKESPSACLRSCSSLVSVYYPL 1273

  Fly   889 ARLL-----SGCAKEIERSALDDL--SLEELLSMQSN----LSLLLGFLDALE------------ 930
            ||.|     |.|..|::.|..:||  :|.:.||...|    ..:||..::.:|            
Yeast  1274 ARELFNASFSSCWVELQTSYQEDLIQALCKALSSSENPPEIYQMLLNLVEFMEHDDKPLPIPIHT 1338

  Fly   931 -------------KLIYNAAEGSAFALRPPEKQVAAFFRLNNPTCQSWFNRIRIGVVIIAMHVQQ 982
                         .|.|...|   |...|....:.|...:||...|:   ...||          
Yeast  1339 LGKYAQKCHAFAKALHYKEVE---FLEEPKNSTIEALISINNQLHQT---DSAIG---------- 1387

  Fly   983 PELVIRYAQQILVNSKTQDPTYSQAIVYMAWSLVSCQEADSLRGLRLWARGKSCKSYKWLKYAAD 1047
               ::::|||                            .:.|:....|..    |..:|      
Yeast  1388 ---ILKHAQQ----------------------------HNELQLKETWYE----KLQRW------ 1411

  Fly  1048 QAAGKRESALAGYRTILAEKELQSE--LEPHTRQFVVSQMMQCLQDLGQWSQLVELKQQQ--MTR 1108
                  |.|||.|.    |||...|  :|      |:...::.|..||:|.:|.:|..::  ..:
Yeast  1412 ------EDALAAYN----EKEAAGEDSVE------VMMGKLRSLYALGEWEELSKLASEKWGTAK 1460

  Fly  1109 PEDRELNPFLQRSNVEVNALERLLAKSEESCSSMDALGGVFQQLSLWPSNWDESVSSSGLSERAS 1173
            ||.::             |:..|.|         .|..|:.|        |||.         |.
Yeast  1461 PEVKK-------------AMAPLAA---------GAAWGLEQ--------WDEI---------AQ 1486

  Fly  1174 FSSIHMRQRTED-------IVLH----KLLEDRCVPDQAKNLLDTQWRDSLLNPSFDQRSCKELT 1227
            ::|: |:.::.|       :.||    |..|....  .|::||.|: ..:|:|.|:::  ...:.
Yeast  1487 YTSV-MKSQSPDKEFYDAILCLHRNNFKKAEVHIF--NARDLLVTE-LSALVNESYNR--AYNVV 1545

  Fly  1228 LLRHIVQGVSGGQELSLLPVSSGRCQNRSKFIS-----SAILMRCL----AWTQLLRQH---CAP 1280
            :...|:..:....:...||      ||..|.::     :..|:.|.    .|.::||..   ..|
Yeast  1546 VRAQIIAELEEIIKYKKLP------QNSDKRLTMRETWNTRLLGCQKNIDVWQRILRVRSLVIKP 1604

  Fly  1281 GSWETLCLDAAAAAREEGNLQLAETLLTQFFGQPIGEIAALFSLEQGVQTDNPEMLRGYSELVKC 1345
            .....:.:..|...|:.|.:.||:.:|...             ||   :||:|:           
Yeast  1605 KEDAQVRIKFANLCRKSGRMALAKKVLNTL-------------LE---ETDDPD----------- 1642

  Fly  1346 LHLQQQQSQTHSGDLSSSIDVCAALCLNIQKSNNQPAAGADLLLNLADWIAVRTCNGLTTNQSPV 1410
                      |.....:|..|..|....:..:..|..| ...|:|...    |..:.|..:.:.:
Yeast  1643 ----------HPNTAKASPPVVYAQLKYLWATGLQDEA-LKQLINFTS----RMAHDLGLDPNNM 1692

  Fly  1411 LIQLLDQLPECPLTCDSSQPLAIPQAERMVARLVHSCLQQRPNYAEALIAYGNW--CY--RWGKK 1471
            :.|                  ::||..:.|.|.|....:.   .|...:..|.|  |.  :|...
Yeast  1693 IAQ------------------SVPQQSKRVPRHVEDYTKL---LARCFLKQGEWRVCLQPKWRLS 1736

  Fly  1472 VADSC----CVLTQADATAISQALDIPQPLESEKLDELLQALSTEQPPANCVEVCPDAARARDDE 1532
            ..||.    .:.|..|.|......:  ..|.:.::..:|.::|.::...:      ||:...|..
Yeast  1737 NPDSILGSYLLATHFDNTWYKAWHN--WALANFEVISMLTSVSKKKQEGS------DASSVTDIN 1793

  Fly  1533 AAKNRLRRLTFLADKTPEALDAILQIWRRAIANTYD----YYKD---------AARSYFQYLSFK 1584
            ...|.:..:                       ||:|    :|..         |.:.:|..:|  
Yeast  1794 EFDNGMIGV-----------------------NTFDAKEVHYSSNLIHRHVIPAIKGFFHSIS-- 1833

  Fly  1585 SGSGPEKPEGEGVVSQRERLHVDDSNLVTTTLRLLRLIVKHASGLQE---VLEQGLHTTPIAPWK 1646
                                 :.:|:.:...||||.|.... .|:.|   .:.:|.:...|..|.
Yeast  1834 ---------------------LSESSSLQDALRLLTLWFTF-GGIPEATQAMHEGFNLIQIGTWL 1876

  Fly  1647 VIIPQLFSRLNHHEPYVRKSVCDLLCRLAKSRPQLVIFPAVVGANRE---QQDATAPPATARPTT 1708
            .::|||.||::.....|.:|:..||..|.|:.||.:::|.:|....|   :|.|...        
Yeast  1877 EVLPQLISRIHQPNQIVSRSLLSLLSDLGKAHPQALVYPLMVAIKSESLSRQKAALS-------- 1933

  Fly  1709 EDACCYGYLLGELSKQAPEAVQHVKLMVKELRRVCLLWDEYWIHSLAHIYNTYVSRVSALATDFR 1773
                    ::.::...:|..|...:|:..||.|:.:||.|.|...|                   
Yeast  1934 --------IIEKMRIHSPVLVDQAELVSHELIRMAVLWHEQWYEGL------------------- 1971

  Fly  1774 PDDHE----GKNNRFNVWRPQLLADLEALVAVTSRPPETTYERSFRKRFDAPIRLTVDALRHRR- 1833
             ||..    |::|     ..::.|.||.|..:..|.|||..|.||:..|...:....:.|.:.: 
Yeast  1972 -DDASRQFFGEHN-----TEKMFAALEPLYEMLKRGPETLREISFQNSFGRDLNDAYEWLMNYKK 2030

  Fly  1834 ------YPEAWDKLKQLYHILQSNMIRGSG------STLKMQSISPVLCGIGRMRISMPGLDAHG 1886
                  ..:|||    :|:    |:.|..|      .||::|.:||.|.....:.:::||..|.|
Yeast  2031 SKDVSNLNQAWD----IYY----NVFRKIGKQLPQLQTLELQHVSPKLLSAHDLELAVPGTRASG 2087

  Fly  1887 PDGDQ-VYIESVESSVCVLPTKTKPKKVAFYGSNGQRYTFLFKGMEDLHLDERIMQFLSISNAIM 1950
              |.. |.|...|....|:.:|.:|:|....||:|:.|.::.||.||:..|..:||...:.|.::
Yeast  2088 --GKPIVKISKFEPVFSVISSKQRPRKFCIKGSDGKDYKYVLKGHEDIRQDSLVMQLFGLVNTLL 2150

  Fly  1951 ACRSDAPGNGCYRAH----HYSVIPLGPQSGLISWVDGVTPVFALYKKWQQRRSQVAGNAGAGAV 2011
              ::||.   |:|.|    .|..|||.|:|||:.||........|.::.::.             
Yeast  2151 --QNDAE---CFRRHLDIQQYPAIPLSPKSGLLGWVPNSDTFHVLIREHREA------------- 2197

  Fly  2012 ANVPRRFTDLFYNKLSPLLAKHNMQVSDPRRQWPISVLLQV---LDELS------------QETP 2061
                         |..||..:|          |   |:||:   .|.|:            ..|.
Yeast  2198 -------------KKIPLNIEH----------W---VMLQMAPDYDNLTLLQKVEVFTYALNNTE 2236

  Fly  2062 NDLLARELWCQAGNAAEWRQSVRRFVRCMSVMSMIGYVIGLGDRHLDNVLINLGSGDIVHIDYNV 2126
            ...|.:.||.::.::..|.:....:.|.::||||.||::||||||..|::::..:|.::|||:..
Yeast  2237 GQDLYKVLWLKSRSSETWLERRTTYTRSLAVMSMTGYILGLGDRHPSNLMLDRITGKVIHIDFGD 2301

  Fly  2127 CFEKGRTLR--IPEKVPFRLTQNLVQAMGITGIEGPFRLGCEYVLKVMRKERETLLTLLEAFVYD 2189
            ||| ...||  .|||||||||:.|..||.::||||.||:.||.|:||:|..:.:|:.:||||.:|
Yeast  2302 CFE-AAILREKFPEKVPFRLTRMLTYAMEVSGIEGSFRITCENVMKVLRDNKGSLMAILEAFAFD 2365

  Fly  2190 PLVDWTTNDDAQALRRSLNAKLQESADGGGAGGLGVGDLKYHKKDKNKGKPLDSDVKRQPFLSKL 2254
            ||::|                           |.   ||...|.::..|..|       |.:   
Yeast  2366 PLINW---------------------------GF---DLPTKKIEEETGIQL-------PVM--- 2390

  Fly  2255 GMLQKYWSTNKTELMPQLEEMEQEVGNLQAAQAKQVVAEEELVKLNQRSALIAEIKSLGTAIESH 2319
                     |..||:                 :...:.|||:.::....                
Yeast  2391 ---------NANELL-----------------SNGAITEEEVQRVENEH---------------- 2413

  Fly  2320 SFNTASLRNAVRRGHSEALALLSTERLPDFGRVQCILRSYGQCLQLYHLLDLQGQLVKL-QMESN 2383
                   :||:|    .|.|:|..:|:.|        :..|..::.::.||:..|:.|| |..::
Yeast  2414 -------KNAIR----NARAMLVLKRITD--------KLTGNDIRRFNDLDVPEQVDKLIQQATS 2459

  Fly  2384 SEN 2386
            .||
Yeast  2460 VEN 2462

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nonCNP_001284967.1 SMG1 571..1140 CDD:292413 123/700 (18%)
Rapamycin_bind 1738..1845 CDD:285924 28/117 (24%)
PIKKc_SMG1 1894..2196 CDD:270714 105/322 (33%)
FATC 3189..3217 CDD:280430
TOR2NP_012719.2 TEL1 290..2474 CDD:227365 515/2538 (20%)
HEAT repeat 599..620 CDD:293787 2/20 (10%)
HEAT repeat 642..667 CDD:293787 6/37 (16%)
HEAT repeat 677..707 CDD:293787 4/29 (14%)
HEAT repeat 715..748 CDD:293787 9/39 (23%)
HEAT repeat 758..787 CDD:293787 9/30 (30%)
HEAT repeat 801..828 CDD:293787 7/26 (27%)
HEAT repeat 843..873 CDD:293787 8/33 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11139
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
22.000

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