Protein Alignment nonC and MEC1

DIOPT Version :9

• Sequence 1: NP_001284967.1
• Gene: nonC / 31625
• FlyBaseID: FBgn0263968
• Length: 3218
• Species: Drosophila melanogaster
• Sequence 2: NP_009694.3
• Gene: MEC1 / 852433
• SGDID: S000000340
• Length: 2368
• Species: Saccharomyces cerevisiae
• Alignment Length: 2412
• Identity: 447/2412 - (18%)
• Similarity: 765/2412 - (31%)
• Gaps: 895/2412 - (37%)

  Fly    79 SHDVAQAFANALL------------------LRNMNHVVGKGQPVVQ----NHRKAYQCKGDTIN 121
            ||.....|:.:||                  |.:.|..:.|...:||    |..:..:.....|.
Yeast   528 SHPNIDEFSESLLSGILFSLHRIFSHFQPPKLTDGNGQINKSFKLVQKCFMNSNRYLRLLSTRII 592

  Fly   122 PM------ANGEDLRLSKIIRRLINENNPTVSLELCSKLDQAVRTPINMGYMTCSFVWI------ 174
            |:      .|.||...:.:|:.|.::..|.|...|.....|...|..|..:.|.....|
Yeast   593 PLFNISDSHNSEDEHTATLIKFLQSQKLPVVKENLVIAWTQLTLTTSNDVFDTLLLKLIDIFNSD 657

  Fly   175 -----------LDNMLTLYKQCP--------PPVLEECSKTL-----------GLIGFINRKSYP 209
                       :.||..:.|:.|        |.:|.:..|.|           .|:|:.::....
Yeast   658 DYSLRIMMTLQIKNMAKILKKTPYQLLSPILPVLLRQLGKNLVERKVGFQNLIELLGYSSKTILD 722

  Fly   210 IYEEFIVK----NYKSSKRMQKYMIMALRATLSCDTKCELHMYADKIMLLLKD------------ 258
            |::.:|:.    .|||.       :::..|.:.||....| :...|:.||.|:
Yeast   723 IFQRYIIPYAIIQYKSD-------VLSEIAKIMCDGDTSL-INQMKVNLLKKNSRQIFAVALVKH 779

  Fly   259 -----------FLENAESAD-----IFIVVSNTLVQFAASYAETFECHFTDVVD----------I 297
                       ||..|.:.|     .::....||.:....|..:.....:|..:          :
Yeast   780 GLFSLDILETLFLNRAPTFDKGYITAYLPDYKTLAEITKLYKNSVTKDASDSENANMILCSLRFL 844

  Fly   298 VIGWQLEAGQPTDLKTHCAQVLEQLTPFFSKQIDFSYGLLDQFVEDITTLEEGEPANTA--ERVG 360
            :..::.:....:..|.......:|...|..|..|...|:...|..||..:|    ..|.  |::.
Yeast   845 ITNFEKDKRHGSKYKNINNWTDDQEQAFQKKLQDNILGIFQVFSSDIHDVE----GRTTYYEKLR 905

  Fly   361 AFVG-AF-------NTLLKCLARMQIFVGMPTCECIVKMAVD-----HLIKIMPTLHLNTEALVN 412
            ...| :|       .:::..||  ||.:.:.|...:.::..:     ||:    ..|||.|.|..
Yeast   906 VINGISFLIIYAPKKSIISALA--QISICLQTGLGLKEVRYEAFRCWHLL----VRHLNDEELST 964

  Fly   413 -INELICICL--LNNFTGLDPILLEQVLLDQVKRMISLTELQRQSVLYLLLCTVRRLRARLTPSL 474
             |:.||...|  .:.|.|                       :.::::|.:|.|:.:.::.|
Yeast   965 VIDSLIAFILQKWSEFNG-----------------------KLRNIVYSILDTLIKEKSDL---- 1002

  Fly   475 VHFIFQSNPYMTKVRLRSPGETSYKLLLRTCQETLLIRN-------VPL----LQQAYKYLV--- 525
               |.:..||.|   |...|:....:|.|..|...::..       :|:    |:.:.||::
Yeast  1003 ---ILKLKPYTT---LALVGKPELGILARDGQFARMVNKIRSTTDLIPIFANNLKSSNKYVINQN 1061

  Fly   526 -DDIDACL-----EKLLITAPRSKARKASVLLVFHLSALAALAKQTSSIIGM-----YACKPSIL 579
             |||:..|     |:.:...|:...:.:.:.||     |.||...:.....:     ..|...|.
Yeast  1062 LDDIEVYLRRKQTERSIDFTPKKVGQTSDITLV-----LGALLDTSHKFRNLDKDLCEKCAKCIS 1121

  Fly   580 ELLLTNCRAHELKFWSKYPAAQQAIFGLLVVHCQANHNFRTNSSLLRDQELSAENTSPTANSFAS 644
            .:.:.:...||.|                          ||..|         ||.....|....
Yeast  1122 MIGVLDVTKHEFK--------------------------RTTYS---------ENEVYDLNDSVQ 1151

  Fly   645 ILRFLDSVLG--------QAHQLAPQNLRVLLQWIQMLLREC---REKIDLLMEQENFRGICRNI 698
            .::||..|:.        |:...:.|....|:  ||..|:.|   .|..|:     |.:.:..|.
Yeast  1152 TIKFLIWVINDILVPAFWQSENPSKQLFVALV--IQESLKYCGLSSESWDM-----NHKELYPNE 1209

  Fly   699 AATASKLVPLESAACIQTVLDYGLERLEKYPKLLILYRDTALQQ---LQMLSTNYHAPYFQIYAQ 760
            |....|.              ..:.:...||.|..||...:.::   |:..|.|:...|.....:
Yeast  1210 AKLWEKF--------------NSVSKTTIYPLLSSLYLAQSWKEYVPLKYPSNNFKEGYKIWVKR 1260

  Fly   761 LPLHLTLTGGESSMP------------GMASR--------RVSVWQQRISQYSAVR-------DN 798
            ..|.|..||...:.|            |..|.        .:.:..::.:.|:.:.       |:
Yeast  1261 FTLDLLKTGTTENHPLHVFSSLIREDDGSLSNFLLPYISLDIIIKAEKGTPYADILNGIIIEFDS 1325

  Fly   799 VFRDFFDRVQKPEQDSLIHCLRELF--VRSCQVAPQDERQMNLSQC--------TKRCQRLAIAW 853
            :|....:.:...:.|||..|...:|  ...|:....:.:| |.|:.        ||....|
Yeast  1326 IFTCNLEGMNNLQVDSLRMCYESIFRVFEYCKKWATEFKQ-NYSKLHGTFIIKDTKTTNML---- 1385

  Fly   854 LQFEAARYCVDQRLRTTVGKPQETFL-------GFEAIIMRHARLLSGCAKEIERSALDDLSLEE 911
                   ..:|:.||||   |.:...       .||    |.|..|..|.::   :..|.....:
Yeast  1386 -------LRIDEFLRTT---PSDLLAQRSLETDSFE----RSALYLEQCYRQ---NPHDKNQNGQ 1433

  Fly   912 LLSMQSNLSLL---LGFLDALEKLIYNAAEGSAFALRPPEKQVAAFFRLNNPTCQSWFNRIRIGV 973
            ||   .||.:.   :|.:|:|:.::...|.|:..: :..|.|.:..::|    .|..||
Yeast  1434 LL---KNLQITYEEIGDIDSLDGVLRTFATGNLVS-KIEELQYSENWKL----AQDCFN------ 1484

  Fly   974 VIIAMHVQQPELVIRYAQQILVNSKTQDPTYSQAIVYMAWSLVSCQEADSLRGLRLWARGKSCKS 1038
             ::......|:...|     ::.|......|||.|     |..|...:|          ||...|
Yeast  1485 -VLGKFSDDPKTTTR-----MLKSMYDHQLYSQII-----SNSSFHSSD----------GKISLS 1528

  Fly  1039 ---YKWLKYAADQAAGKRESALAGYRTILAEKELQSELEPHTRQFVVSQMMQCLQDLGQWSQLVE 1100
               .:|.....:.|                      .||.:            :|.|..|.:.:|
Yeast  1529 PDVKEWYSIGLEAA----------------------NLEGN------------VQTLKNWVEQIE 1559

  Fly  1101 LKQQQMTRPEDRELNPFLQRSNVEVNALERLLAKSEESCSSMDALGGVFQQLSLWPSNWDESVSS 1165
                .:...:|||:       .::.|..:.|:|.|.|.
Yeast  1560 ----SLRNIDDREV-------LLQYNIAKALIAISNED--------------------------- 1586

  Fly  1166 SGLSERASFSSIHMRQRTEDIVLHKLLEDRCVPDQAKNLLDTQWRDSLLNPSFDQRSCKELTLLR 1230
                                            |.:.:..:...:|  |:..:| ..|.||.|||:
Yeast  1587 --------------------------------PLRTQKYIHNSFR--LIGTNF-ITSSKETTLLK 1616

  Fly  1231 --HIVQGVSGGQELSLLPVSSGRCQNRSK--------------FI-SSAILMRCLAWTQLLRQHC 1278
              :::..:....:||.|..:..:.:.:|.              |: :..||....::.||.....
Yeast  1617 KQNLLMKLHSLYDLSFLSSAKDKFEYKSNTTILDYRMERIGADFVPNHYILSMRKSFDQLKMNEQ 1681

  Fly  1279 APGSWETLCLDAAAAAREEGNLQLAETLLTQFFGQPIGEIAALFSLEQGVQTDNPEMLRGYSELV 1343
            |...........|..||....|.:|...|.....:.:.:....|:.....|.:|...|:    :|
Yeast  1682 ADADLGKTFFTLAQLARNNARLDIASESLMHCLERRLPQAELEFAEILWKQGENDRALK----IV 1742

  Fly  1344 KCLHLQQQQSQTHSGDLSSSIDVCAALCLNIQKSNNQPAAGADLLLNLADWIAVRTCNGLTTNQS 1408
            :.:|.:.|:        :||::.               ...|.:||...:|:      .|:.|.:
Yeast  1743 QEIHEKYQE--------NSSVNA---------------RDRAAVLLKFTEWL------DLSNNSA 1778

  Fly  1409 PVLIQLLDQLPECPLTCDS--SQPLAIPQAERMVARLVHSCLQQRPNYAEALIAYGNWCYRWGKK 1471
            ..  |::.|..:. ...||  .:|.       ....|.:|.|.:|.. ||..|..|.:.||
Yeast  1779 SE--QIIKQYQDI-FQIDSKWDKPY-------YSIGLYYSRLLERKK-AEGYITNGRFEYR---- 1828

  Fly  1472 VADSCCVLTQADATAISQALDIPQPLESEKLDELLQALSTEQPPANCVEVCPDAARARDDEAAKN 1536
                          |||..|     |..||                      :.|:.|
Yeast  1829 --------------AISYFL-----LAFEK----------------------NTAKVR------- 1845

  Fly  1537 RLRRLTFLADKTPEALDAILQIWRRAIANTYDYYKDAARSYFQYLSFKSGSGPEKPEGEGVVSQR 1601
                         |.|..::..|                     |...:.|..|.|.     :::
Yeast  1846 -------------ENLPKVITFW---------------------LDIAAASISEAPG-----NRK 1871

  Fly  1602 ERLHVDDSNLVTTTLRLLRLIVKHASGLQEVLEQGLHTTPIAPWKVIIPQLFSRLNHHEPYVRKS 1666
            |                  ::.|....:...:|:.|...|...|..::.||.|||.|......:.
Yeast  1872 E------------------MLSKATEDICSHVEEALQHCPTYIWYFVLTQLLSRLLHSHQSSAQI 1918

  Fly  1667 VCDLLCRLAKSRPQLVIF--PAVVGANREQQDATAPPATARPTTEDACCYGYLLG--------EL 1721
            :..:|..||...|..:::  .|:|.:|..::                    .|.|        :.
Yeast  1919 IMHILLSLAVEYPSHILWYITALVNSNSSKR--------------------VLRGKHILEKYRQH 1963

  Fly  1722 SKQAPEAVQHVKLMVKELRRVCLLWDEYWIHSLAHIYNTYVSRVSALATDFRPDDHEGKNNRFNV 1786
            |:...:.|.....:.|.|.|||
Yeast  1964 SQNPHDLVSSALDLTKALTRVC------------------------------------------- 1985

  Fly  1787 WRPQLLADLEALVAVTSRPPETTYERSFRKRFD---------APIRLTVDALRHRRYPEAWDKLK 1842
                    |:.:.::|||..: :.|:.|  :||         .|:|..:|.:..
Yeast  1986 --------LQDVKSITSRSGK-SLEKDF--KFDMNVAPSAMVVPVRKNLDIISP----------- 2028

  Fly  1843 QLYHILQSNMIRGSGSTLKMQSISPVLCGIGRMRISMPGLDAHGPDGDQVYIESVESSVCVLPTK 1907
                 |:||.:||      .|...||                       |.|....||..|..:.
Yeast  2029 -----LESNSMRG------YQPFRPV-----------------------VSIIRFGSSYKVFSSL 2059

  Fly  1908 TKPKKVAFYGSNGQRYTFLFKGMEDLHLDERIMQFLSISNAIM----ACRSDAPGNGCYRAHHYS 1968
            .|||::...||:|..|..:.| .||:..|.:.|||.:..:.::    |.|..:.|     .:.||
Yeast  2060 KKPKQLNIIGSDGNIYGIMCK-KEDVRQDNQYMQFATTMDFLLSKDIASRKRSLG-----INIYS 2118

  Fly  1969 VIPLGPQSGLISWVDGVT-----------------PVFALYKKWQQRRSQVAGNAGAGAVANVPR 2016
            |:.|....|::..|..|.                 .:.:|:.:||  .:.|.|...
Yeast  2119 VLSLREDCGILEMVPNVVTLRSILSTKYESLKIKYSLKSLHDRWQ--HTAVDGKLE--------- 2172

  Fly  2017 RFTDLFY----NKLSPLLAKHNMQVSDPRRQW-------PISVLLQVLDELSQETPNDLLARELW 2070
                 ||    :|..|:|           .||       ||:                      |
Yeast  2173 -----FYMEQVDKFPPIL-----------YQWFLENFPDPIN----------------------W 2199

  Fly  2071 CQAGNAAEWRQSVRRFVRCMSVMSMIGYVIGLGDRHLDNVLINLGSGDIVHIDYNVCFEKGRTLR 2135
            ..|.|.         :.|..:||:|:|:::||||||.:|:|:::.:|.::|:|::..||||:.|.
Yeast  2200 FNARNT---------YARSYAVMAMVGHILGLGDRHCENILLDIQTGKVLHVDFDCLFEKGKRLP 2255

  Fly  2136 IPEKVPFRLTQNLVQAMGITGIEGPFRLGCEYVLKVMRKERETLLTLLEAFVYDPLVDWTTNDDA 2200
            :||.||||||.||:.|:||.|.||.|:...|..|.:|||....|:.::|..:||..:|.:.....
Yeast  2256 VPEIVPFRLTPNLLDALGIIGTEGTFKKSSEVTLALMRKNEVALMNVIETIMYDRNMDHSIQKAL 2320

  Fly  2201 QALRRSL 2207
            :.||..:
Yeast  2321 KVLRNKI 2327

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nonC	NP_001284967.1	SMG1	571..1140	CDD:292413	115/637 (18%)
		Rapamycin_bind	1738..1845	CDD:285924	15/115 (13%)
		PIKKc_SMG1	1894..2196	CDD:270714	93/333 (28%)
		FATC	3189..3217	CDD:280430
MEC1	NP_009694.3	TEL1	194..2368	CDD:227365	447/2412 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900