Protein Alignment nonC and STT4

DIOPT Version :9

• Sequence 1: NP_001284967.1
• Gene: nonC / 31625
• FlyBaseID: FBgn0263968
• Length: 3218
• Species: Drosophila melanogaster
• Sequence 2: NP_013408.1
• Gene: STT4 / 851014
• SGDID: S000004296
• Length: 1900
• Species: Saccharomyces cerevisiae
• Alignment Length: 2243
• Identity: 387/2243 - (17%)
• Similarity: 712/2243 - (31%)
• Gaps: 762/2243 - (33%)

  Fly   130 RLSKIIR---RLINENNP--TVSLELCSKLDQAV-RTPI---NMGYMTCSFVWILDNMLTLY--K 183
            |:|.::.   :|....||  .::.:|...:.||. :.|:   |:|.:..::   .:.:|.::  |
Yeast   103 RISDVLSSKFKLEQMRNPIELLTFQLTKFMIQACEQYPVLYENIGGIISTY---FERVLKIFTIK 164

  Fly   184 QCPPPVLEECSKTLGLIGFINRKSYPIYEEFIVKNYKSSKRMQKY-----MIMALRATLSCDTKC 243
            |         |..|.|:||||        .||  .:.:|..:.|:     ..:.||.:...:
Yeast   165 Q---------SGLLSLVGFIN--------AFI--QFPNSTELTKFTWKKLAKLVLRGSFLNE--- 207

  Fly   244 ELHMYADKIMLLLKDFLENAESADIFIVVSNTLVQFAASYAETFECHFTDVVDIVIGWQLEAGQP 308
                 .|||:          .|:..|  .::::||:..:..|....:..:::.     :|:....
Yeast   208 -----VDKIL----------NSSATF--TNDSIVQYYDAGNELSSAYLLELIS-----RLQVSLI 250

  Fly   309 TDLKTHCAQVLEQLTPFFSKQIDFSYGLLDQFVEDITTLEEGEPANTAERVGAFVGAFNTLLKCL 373
            :.| .:.:.|...|:.|...| .:.:...||.|.|       |..:|               ||:
Yeast   251 SHL-LNTSHVGANLSEFLLNQ-QYQFYKFDQEVAD-------ENDDT---------------KCI 291

  Fly   374 --------ARMQIFVGMPTCECIVKMAVD-HLIKIMPTLHLNTEALVNINELICICLLNNFTGLD 429
                    :..|.|..|  |:..::...: |::.:..............:.|..:||:......:
Yeast   292 DDFFFNVRSNKQFFTDM--CKISLQFCSESHILDLSTDNRARFSFDTRAHYLQTLCLIPFIEDTE 354

  Fly   430 PILLEQVLLDQVKRMISLTELQRQSVLYLLLCTVRRLRARLTPSLVHFIFQS----NPYMTKVRL 490
            ..|.|           |.|.:..:|:....|..|      :||||:..|..|    |.:..|:.|
Yeast   355 SELFE-----------SFTNVVSESIDKFFLSDV------VTPSLIKAIVASASLLNFFTEKLSL 402

  Fly   491 RSPGETSYKLLLRTCQETLLIRNVPLLQQAYKYLVDDIDACLEKLLITAPRSKARKASVLLVFHL 555
                              .|||..||| .|..::..:....:.|:..|........|.|..::.:
Yeast   403 ------------------TLIRMFPLL-VASPHITTETVNDVAKIFTTGLYPLNEDAIVSTIYSM 448

  Fly   556 SALAALAKQTSSIIGMYACKPSILE-----------------------------LLLTNCRAHEL 591
            :.|.|:::..|.:       |.:.|                             .||.|....:|
Yeast   449 NNLLAVSEDGSPV-------PVLRERQLTITSGKNIEKDYFPLRNSSASLDGTGALLGNTTVGQL 506

  Fly   592 KFWSKYPAAQQAIFGLLVVHCQANHNFRTNSSLLRDQELSAENTSPTANSFASILRFLDSV-LGQ 655
            ........|.......|:.:|.|...  |.:|....|.::|...|.......|:.:.||.| |..
Yeast   507 SSHDVNSGATMTYHASLISNCVAATT--TIASYYNTQSITALTISILTQKVNSMSKELDGVILNS 569

  Fly   656 AHQLAPQNLRVLLQWIQMLLRECREKIDLLMEQENFRGICRNIAATASKLVPLESAACIQTVLDY 720
            ..:|||   ...|....:||:..:.               |.:.||     .::.:|.::.::.
Yeast   570 LARLAP---NTSLTEFSLLLKFFKS---------------RTVIAT-----KIDDSALLKNIIK- 610

  Fly   721 GLERLEKYPKLLILYRDTALQQLQMLSTNYHAPYFQIYAQLPLHLTLTGGESSMPGMASRRVSVW 785
                    .|.:|        ..::|:.::.:..:.:|....|...:..||
Yeast   611 --------AKCVI--------SKELLARHFSSDLYFMYLHDLLDSIIASGE-------------- 645

  Fly   786 QQRISQYSAVRDNVFRDFFDRVQKPEQDSLIHCLRELFVRSCQVAPQDERQMNLSQCTKRCQRLA 850
            .:|:..:....:      ..||    .|.:...|..|   :..:....:..:::::......:..
Yeast   646 VERLEHHRPQTE------ISRV----ADQIATYLEPL---AALLPVPGDTPLDINKDEVTTNKFR 697

  Fly   851 IAWLQFEAARYCVDQRLRTTVGKPQETFLGFEAIIMRHARLLSGCAKEIERSALDDLSLEELLSM 915
            .||..|....|        .:|.|         |:.|
Yeast   698 NAWFNFVIHGY--------HLGGP---------IVKR---------------------------- 717

  Fly   916 QSNLSLLLGFLDALEKLIYNAAEGSAFALRPPEKQVAAFFRLNNPTCQSWFNRI-RIGVVIIAMH 979
              |.|.||       .:.||:         ||   :|:.|..||.......|.| |.|.....:.
Yeast   718 --NFSFLL-------TIAYNS---------PP---LASEFPANNKELSLEMNTILRRGSSNENIK 761

  Fly   980 VQQPELVIRYAQQILVNSKTQDPTYSQAIVYMAWSL----VSCQEADSLRGLRLWARGKSCKSYK 1040
             ||.:.:..|....:|..:|   |.|..|:::|.::    :.|:..|             |.  |
Yeast   762 -QQKQQITEYFNTNIVQYRT---TSSSKIMFLAAAVLLETIRCEAGD-------------CS--K 807

  Fly  1041 WLKYAADQA--AGKRESALAGYRTILAEKELQSELEPHTRQFVVSQMMQCLQDLGQWSQLVELKQ 1103
            .|.|.:|.:  :|..|..:|                      |:|..|
Yeast   808 TLLYFSDPSILSGSIEKCIA----------------------VLSVSM----------------- 833

  Fly  1104 QQMTRPEDRELNPFLQRSNVEVNALERLLAKSEESCSSMDALGGVFQQLSLWPSNWDESVSSSGL 1168
                                 :....||:.|..::..:...:......|.|..|:.:.::
Yeast   834 ---------------------IRKYARLIQKGNDAIFNSKMIAQQLNNLLLCLSHREPTL----- 872

  Fly  1169 SERASFSSIHMRQRTEDIVLHKLLEDRCVPDQAKNLLD--TQWRDSLLNPSFDQRSCKELTLLRH 1231
             :.|:|.:.       :|.:..:....|.......|||  |...||:|:....:...:....|:|
Yeast   873 -QDAAFHAC-------EIFIRSIPSSLCHHLSLYTLLDMLTALFDSILDSEAHKFEPRYEFKLKH 929

  Fly  1232 IVQGVSGGQELSLLPVSSGRCQNRSKFISSAILMRCLAW--TQLLRQHCAPGSWETLCLDAAAAA 1294
                   .:...|:|.||                   :|  |.|.|.|.:...|..:.|
Yeast   930 -------SKTTILVPSSS-------------------SWRATTLSRLHKSAKEWVRILL------ 962

  Fly  1295 REEGNLQLAET-LLTQFFGQPIGEIAALFSLEQGVQ-----------------------TDNPEM 1335
                |....:| :|.|.:...:||.:.|.|:|.||.                       .:.|..
Yeast   963 ----NRSNQDTKILLQSYISDLGEYSRLNSVEFGVSFAMDMAGLILPADKELSRLTYYGPEKPNT 1023

  Fly  1336 LRGYSELVKCLHLQQQQSQTHSGDLSSSIDVCAALCLNIQKSNNQPAAGADLLL-NLADWIAVRT 1399
            :.|:..    ||..:.:....:...||..|:...:.::.|........|..::. ::.|::.:.|
Yeast  1024 ISGFIS----LHSWRSKYLFDTAITSSPEDIKRQIGISTQNIRKNLTLGNKIITKDVTDFLDMAT 1084

  Fly  1400 CNGLTTNQSPVLIQLLDQLPECPLTCDSSQPLAIPQAERMVARLVHSCLQQRPNYAEALIAYGNW 1464
            ...:..|.:|.  .|:..:...|....:|..|      ::...:..:.:.::|..|..|:.  ..
Yeast  1085 ALLILGNGAPA--SLIYDIVHIPFEVFTSASL------KIATNVWLTIITEKPEVAHLLLV--EV 1139

  Fly  1465 CYRWGKKVADSCCVLTQADATAISQALDIPQPLESEKLDELLQALSTEQPPANCVEVCPDAARAR 1529
            ||.|.:.:.|:..:.::            ...|:.|:..::      |..|.:...:..||..|
Yeast  1140 CYCWMRSIDDNIGLYSR------------DHDLKGEEYQKM------EYSPYDKAGINRDAKNA- 1185

  Fly  1530 DDEAAKNRLRRLTFLADKTPEAL---DAILQIWRR-AIANTYDYYKDAARSYFQYL--------- 1581
             .:|.:..|..:.|.|......|   |.:|:|:.: |:....:.||.:...:.:.:
Yeast  1186 -SQAMQPHLHVIKFFASHFEGTLFQSDFLLKIFTKCALYGIKNLYKASLHPFARMIRHELLLFAT 1249

  Fly  1582 -----SFKSGS---GPEKPE-GEGVVSQRER----------LHVDDSNLVTTTL-----RLLRLI 1622
                 |:|.||   |....| ..|.:|..:|          |.:.....||..|     :|..|:
Yeast  1250 LVLNASYKQGSKYMGRLSQEITNGALSWFKRPVAWPFGSNELKIKADLSVTRDLFLQLNKLSSLM 1314

  Fly  1623 VKHASGLQEVLEQGL--HTTPIAPW-----KV-----------IIPQLFSRLNHHEP-------- 1661
            .:|.....::|...|  ....|..|     |:           |:...|::    :|
Yeast  1315 SRHCGKDYKILNYFLASEIQQIQTWLTPTEKIEGADSNELTSDIVEATFAK----DPTLAINLLQ 1375

  Fly  1662 --YVRKSVCDLLCRLAKSRPQLVIFPAVVG--------ANREQQDATAPPATARPTTE------- 1709
              |.:|:...|:..:||.....|..|:.:.        ::::...||...|...|...
Yeast  1376 RCYSKKAEDVLVGLVAKHALMCVGSPSALDLFIKGSHLSSKKDLHATLYWAPVSPLKSINLFLPE 1440

  Fly  1710 ---DACCYGYLLGELSKQ--------APEAVQ--------HVKLMVKELRRVCLLWDEYWI-HSL 1754
               ::....:.:..|..|        .|:.||        :|:.::.:..::.:|:....| :.|
Yeast  1441 WQGNSFILQFSIYSLESQDVNLAFFYVPQIVQCLRYDKTGYVERLILDTAKISVLFSHQIIWNML 1505

  Fly  1755 AHIYNTYVSRVSALATDFRPDDHEGKNNRFNVWRPQLLADLEALVAVTSRPPETTYERSFRKRFD 1819
            |:.|.                |.||...  :..:|.|....|.:|:..|:.....|||.| :.||
Yeast  1506 ANCYK----------------DDEGIQE--DEIKPTLDRIRERMVSSFSQSHRDFYEREF-EFFD 1551

  Fly  1820 ---------APIRLTVDALRHRRYPEAWDKLK---QLYHILQSN-------MIRGSGSTLKMQSI 1865
                     .|......|.:..:..|...|::   .:|  |.||       :.|.||..|:..:.
Yeast  1552 EVTGISGKLKPYIKKSKAEKKHKIDEEMSKIEVKPDVY--LPSNPDGVVIDIDRKSGKPLQSHAK 1614

  Fly  1866 SPVLCGIGRMRISMPGLDAHGPDGDQVYIESVESSVCVLPTKTKPKKVAFYGSNGQRYTFLFKGM 1930
            :|.:   ...:|.....|                     |...|.|:|..:      ...:||..
Yeast  1615 APFM---ATFKIKKDVKD---------------------PLTGKNKEVEKW------QAAIFKVG 1649

  Fly  1931 EDLHLDERIMQFLSISNAIMACRSDAPGNGCYRAHHYSVIPLGPQSGLISWVDGVTPVFALYKKW 1995
            :|...|...:|.:|:...|.:    :.|...| ...|.|....|..|:|.    |.|
Yeast  1650 DDCRQDVLALQLISLFRTIWS----SIGLDVY-VFPYRVTATAPGCGVID----VLP-------- 1697

  Fly  1996 QQRRSQVAGNAGAGAVANVPRRFTDLFYNKLSPLLAKHNMQVSDPRRQWPISVLLQVLDELSQET 2060
               .|......|..||..:...||..|.|:
Yeast  1698 ---NSVSRDMLGREAVNGLYEYFTSKFGNE----------------------------------- 1724

  Fly  2061 PNDLLARELWCQAGNAAEWRQSVRRFVRCMSVMSMIGYVIGLGDRHLDNVLINLGSGDIVHIDYN 2125
                          :..|::.:...||:.::..|:|.|::...|||..|::.: ..|..:|||:.
Yeast  1725 --------------STIEFQNARNNFVKSLAGYSVISYLLQFKDRHNGNIMYD-DQGHCLHIDFG 1774

  Fly  2126 VCFEKGRTLRIP-----EKVPFRLTQNLVQAMG 2153
            ..|:     .:|     |.|||:||:.:|:.||
Yeast  1775 FIFD-----IVPGGIKFEAVPFKLTKEMVKVMG 1802

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nonC	NP_001284967.1	SMG1	571..1140	CDD:292413	92/605 (15%)
		Rapamycin_bind	1738..1845	CDD:285924	23/119 (19%)
		PIKKc_SMG1	1894..2196	CDD:270714	53/265 (20%)
		FATC	3189..3217	CDD:280430
STT4	NP_013408.1	TEL1	1..1900	CDD:227365	387/2243 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900