Protein Alignment nonC and TOR

DIOPT Version :9

• Sequence 1: NP_001284967.1
• Gene: nonC / 31625
• FlyBaseID: FBgn0263968
• Length: 3218
• Species: Drosophila melanogaster
• Sequence 2: NP_175425.2
• Gene: TOR / 841427
• AraportID: AT1G50030
• Length: 2481
• Species: Arabidopsis thaliana
• Alignment Length: 2638
• Identity: 528/2638 - (20%)
• Similarity: 922/2638 - (34%)
• Gaps: 910/2638 - (34%)

  Fly   101 KGQPVVQNHRKAYQCKGDTINPMANGEDLRLSKIIRRLINENNPTVSLELCSKLDQAVRTPINMG 165
            ||:|:::    |..|.|:....|.:..:..:..::..:.:.   ::|..|...|||
plant   390 KGRPLLE----AVACVGNIAKAMGSTVETHVRDLLDVMFSS---SLSSTLVDALDQ--------- 438

  Fly   166 YMTCSFVWIL----DNML---------TLYKQCPPPVLEECSKTLGLIGFINRKSYPIYEEFIVK 217
             :|.|...:|    |.:|         :.|.|..|||......|:|:
plant   439 -ITISIPSLLPTVQDRLLDCISLVLSKSHYSQAKPPVTIVRGSTVGM------------------ 484

  Fly   218 NYKSSKRMQKYMIMALRATLSCDTKCELHMYADKIMLLLK----------DFLENA-ESADIFI- 270
                             |..|.|..|     :.::.|.|:          |.||.| ||..:::
plant   485 -----------------APQSSDPSC-----SAQVQLALQTLARFNFKGHDLLEFARESVVVYLD 527

  Fly   271 ----------------VVSNTL---VQFAASYA--------ETFECHFTDVVDIVIGWQLEAGQP 308
                            :::|:|   .||.:|.:        ...|    ::|:.::...:.....
plant   528 DEDAATRKDAALCCCRLIANSLSGITQFGSSRSTRAGGRRRRLVE----EIVEKLLRTAVADADV 588

  Fly   309 TDLKT-------------HCAQVLEQLTPFFSKQIDFSYGLLDQFVEDITTLEEGEPA------- 353
            |..|:             :.||. :.||..|:...|....:.:..:.....|.|..||
plant   589 TVRKSIFVALFGNQCFDDYLAQA-DSLTAIFASLNDEDLDVREYAISVAGRLSEKNPAYVLPALR 652

  Fly   354 ---------------NTAERVGAFVGAFNTLLKCLARMQIFVGMPTCECIVKMAVDHLIK---IM 400
                           |......|      .||.||.|....:.:|....:.|..|..|.:   :.
plant   653 RHLIQLLTYLELSADNKCREESA------KLLGCLVRNCERLILPYVAPVQKALVARLSEGTGVN 711

  Fly   401 PTLHLNTEALVNINELICI---CLLNNFTGLDPILLEQVLLD---QVKRMISLTEL--------- 450
            ...::.|..||.:.:|..:   .:......|.|:::| .|:|   ..||.::::.|
plant   712 ANNNIVTGVLVTVGDLARVGGLAMRQYIPELMPLIVE-ALMDGAAVAKREVAVSTLGQVVQSTGY 775

  Fly   451 --------------------------QRQSVLYLL------------------------------ 459
                                      .|:.||.:|
plant   776 VVTPYKEYPLLLGLLLKLLKGDLVWSTRREVLKVLGIMGALDPHVHKRNQQSLSGSHGEVPRGTG 840

  Fly   460 -----LCTVRRLRARLTPSLVHFIFQSNPYMTKVRLRSPGETSYKLLLRTCQETLLI----RNVP 515
                 :.::..|...|.||..    .|..|.:.|.:.|        |:|..::..|:    |.|.
plant   841 DSGQPIPSIDELPVELRPSFA----TSEDYYSTVAINS--------LMRILRDASLLSYHKRVVR 893

  Fly   516 LLQQAYKYL----VDDIDACLEKLLITAPRSKARKASVLLVFHLSALAALAKQTSSIIGMYACKP 576
            .|...:|.:    |..:...|.:|..|. |:........:.:.|..|.::.:|.   |..|.  |
plant   894 SLMIIFKSMGLGCVPYLPKVLPELFHTV-RTSDENLKDFITWGLGTLVSIVRQH---IRKYL--P 952

  Fly   577 SILELLLTNCRAHELKFWSKY--PAAQQAIFGLLVVH-----CQA-NHNFRTNSSLLRDQELSAE 633
            .:|.|:        .:.||.:  |...:...||.|:|     |.| |..|||...::....:...
plant   953 ELLSLV--------SELWSSFTLPGPIRPSRGLPVLHLLEHLCLALNDEFRTYLPVILPCFIQVL 1009

  Fly   634 NTSPTANSFA---SILRFLDSVLG-----QAHQLAPQNLRVLLQWIQMLLRECREKIDLLMEQEN 690
            ..:...|.:.   .||..|: |.|     ..|.|.|..:|:.             |:|..:
plant  1010 GDAERFNDYTYVPDILHTLE-VFGGTLDEHMHLLLPALIRLF-------------KVDAPV---- 1056

  Fly   691 FRGICRNIAATASKLVPLESAACIQT-------------VLDYGLERL----------------- 725
              .|.|:...|.::::|     |:|.             |||...:.|
plant  1057 --AIRRDAIKTLTRVIP-----CVQVTGHISALVHHLKLVLDGKNDELRKDAVDALCCLAHALGE 1114

  Fly   726 ------EKYPKLLILYRDTALQQLQMLSTNYHAPYFQIYAQL----PLHLTLTGGESSMPGMASR 780
                  |...|||:.:|      |:      |..:.:|:|:.    ||.:..|..:     ..||
plant  1115 DFTIFIESIHKLLLKHR------LR------HKEFEEIHARWRRREPLIVATTATQ-----QLSR 1162

  Fly   781 RVSV--------------WQQRISQYSAVRDNVFRDFFDRVQKPEQDSLIHCLRELFVRSCQVAP 831
            |:.|              :::...:...|.|...|...:..|:..::.....:|...:...:.:|
plant  1163 RLPVEVIRDPVIENEIDPFEEGTDRNHQVNDGRLRTAGEASQRSTKEDWEEWMRHFSIELLKESP 1227

  Fly   832 QDERQMNLSQCTKRCQRLAIAWLQFEAARYCVDQRLRTTVGKPQETF-LGFEAIIMRHARLLSGC 895
                    |...:.|.:||               :|:..||:  |.| .||   :...|:|....
plant  1228 --------SPALRTCAKLA---------------QLQPFVGR--ELFAAGF---VSCWAQLNESS 1264

  Fly   896 AKEIERS---ALDDLSL-EELLSMQSNLS--------------LLLGFLDALEK-------LIYN 935
            .|::.||   |....:: .|:|:...||:              .|||.|  .||       |.|.
plant  1265 QKQLVRSLEMAFSSPNIPPEILATLLNLAEFMEHDEKPLPIDIRLLGAL--AEKCRVFAKALHYK 1327

  Fly   936 AAEGSAFALRPPEKQVAAFFRLNNPTCQSWFNRIRIGVVIIAMHV----QQPEL---VIRYAQQI 993
            ..|...    |..|::.|     ||          :.||...:|:    .|.|.   ::.||||.
plant  1328 EMEFEG----PRSKRMDA-----NP----------VAVVEALIHINNQLHQHEAAVGILTYAQQH 1373

  Fly   994 LVNSKTQDPTYSQAIVYMAWSLVSCQEADSLRGLRLWARGKSCKSYKWLKYAADQAAGKR---ES 1055
            | :.:.::..|.:                    |:.|  ..:.|:|. ||  |.|.....   |:
plant  1374 L-DVQLKESWYEK--------------------LQRW--DDALKAYT-LK--ASQTTNPHLVLEA 1412

  Fly  1056 ALAGYRTILAE----------KELQSELEPHTRQFVVSQMMQCLQDLGQWSQLVELKQQQMTRPE 1110
            .|...|.:.|.          ||..|..||..|..:.....|...::|:|.|:.|    .::|.:
plant  1413 TLGQMRCLAALARWEELNNLCKEYWSPAEPSARLEMAPMAAQAAWNMGEWDQMAE----YVSRLD 1473

  Fly  1111 DRELNPFLQRSNVEVNALERLLAKSEESCSSMDALGGVFQQLSLWPSNWDESVSSSGLSERASFS 1175
            |                       .:|:     .|.|:...:|          |..|.|....|.
plant  1474 D-----------------------GDET-----KLRGLASPVS----------SGDGSSNGTFFR 1500

  Fly  1176 SIHMRQRTEDIVLHKLLEDRCVPDQAKNLLDTQWRDSLLNPSFDQR-----SCKELTLLRHIVQG 1235
            ::.:.:|.      |..|.|...::|:..|.|:.. :|:..|:::.     ..::|:.|..::
plant  1501 AVLLVRRA------KYDEAREYVERARKCLATELA-ALVLESYERAYSNMVRVQQLSELEEVI-- 1556

  Fly  1236 VSGGQELSLLPVSSGRCQNRSKFISSAILMRCLAWTQLLRQHCAPGS------WETLC------- 1287
                 |...|||.:...:.|...|.:       .|||.::     ||      |:.|.
plant  1557 -----EYYTLPVGNTIAEERRALIRN-------MWTQRIQ-----GSKRNVEVWQALLAVRALVL 1604

  Fly  1288 ---------LDAAAAAREEGNLQLAETLLTQFFGQPIGEIAALFSLEQGVQTDN------PEMLR 1337
                     |..|:..|:.|.:..|::.|.:           |...:..|..:|      |:::.
plant  1605 PPTEDVETWLKFASLCRKSGRISQAKSTLLK-----------LLPFDPEVSPENMQYHGPPQVML 1658

  Fly  1338 GYSELVKCLHLQQQQSQTHSGDLSSSIDVCAALCLNIQKSNNQPAAGADLLLNLADWIAVRTCNG 1402
            ||        |:.|.|                  |..::...:......:|        .|..:.
plant  1659 GY--------LKYQWS------------------LGEERKRKEAFTKLQIL--------TRELSS 1689

  Fly  1403 LTTNQSPVLIQLLDQLPECPLTCDSSQPLAIPQAERMVARLVHSCLQQRPNYAEALIAYGNWCYR 1467
            :..:||.:|..::           ||:...:|...|:..:|                  |.|  :
plant  1690 VPHSQSDILASMV-----------SSKGANVPLLARVNLKL------------------GTW--Q 1723

  Fly  1468 WGKKVADSCCVLTQADATAISQALDIPQPLESEKLDELLQALSTEQPPANCVEVCPDAARARDDE 1532
            |                 |:|..|:          |..:|.:......:.|  ..|..|:|....
plant  1724 W-----------------ALSSGLN----------DGSIQEIRDAFDKSTC--YAPKWAKAWHTW 1759

  Fly  1533 AAKNRLRRLTFLADKTPEALDAILQ--IWRRAIANTYDYYKDAARSYFQYLSFKSGSGPEKPEGE 1595
            |..|                .|::.  |.|..||:  .|...|...||..::..:.:       :
plant  1760 ALFN----------------TAVMSHYISRGQIAS--QYVVSAVTGYFYSIACAANA-------K 1799

  Fly  1596 GVVSQRERLHVDDSNLVTTTLRLLRLIVKH--ASGLQEVLEQGLHTTPIAPWKVIIPQLFSRLNH 1658
            |         ||||  :...||||.|...|  .:.:|..|:.|.....|..|.|::||:.:|::.
plant  1800 G---------VDDS--LQDILRLLTLWFNHGATADVQTALKTGFSHVNINTWLVVLPQIIARIHS 1853

  Fly  1659 HEPYVRKSVCDLLCRLAKSRPQLVIFPAVVGANREQQDATAPPATARPTTEDACCYGYLLGELSK 1723
            :...||:.:..||.|:.::.||.:::|.:|..   :..:....|.|:...:          ::.:
plant  1854 NNRAVRELIQSLLIRIGENHPQALMYPLLVAC---KSISNLRRAAAQEVVD----------KVRQ 1905

  Fly  1724 QAPEAVQHVKLMVKELRRVCLLWDEYWIHSLAHIYNTYVSRVSALATDFRPDDHEGKNNRFNVWR 1788
            .:...|...:|:..||.||.:||.|.|..:|......|          |...:.||
plant  1906 HSGALVDQAQLVSHELIRVAILWHEMWHEALEEASRLY----------FGEHNIEG--------- 1951

  Fly  1789 PQLLADLEALVAV----TSRPPETTYERSFRKRFDAPIRLTVDALRHR----------------- 1832
              :|..||.|..:    ..:...|..||:|           ::|.||.
plant  1952 --MLKVLEPLHDMLDEGVKKDSTTIQERAF-----------IEAYRHELKEAHECCCNYKITGKD 2003

  Fly  1833 -RYPEAWDKLKQLYHILQS-NMIRGSGSTLKMQSISPVLCGIGRMRISMPGLDAHGPDGDQVYIE 1895
             ...:|||   ..||:.:. :....|.:||.::|:||.|.....:.:::||  .:..|...|.|.
plant  2004 AELTQAWD---LYYHVFKRIDKQLASLTTLDLESVSPELLLCRDLELAVPG--TYRADAPVVTIS 2063

  Fly  1896 SVESSVCVLPTKTKPKKVAFYGSNGQRYTFLFKGMEDLHLDERIMQFLSISNAIMACRSDAPGNG 1960
            |....:.|:.:|.:|:|:..:|::|:.|.||.||.|||..|||:||...:.|.::. .|......
plant  2064 SFSRQLVVITSKQRPRKLTIHGNDGEDYAFLLKGHEDLRQDERVMQLFGLVNTLLE-NSRKTAEK 2127

  Fly  1961 CYRAHHYSVIPLGPQSGLISWVDGVTPVFALYKKWQQRRSQVAGNAGAGAVANVPRRFTDLFYNK 2025
            ......||||||.|.||||.||.....:..|.::.:..|..:........::..|.      |:.
plant  2128 DLSIQRYSVIPLSPNSGLIGWVPNCDTLHHLIREHRDARKIILNQENKHMLSFAPD------YDN 2186

  Fly  2026 LSPLLAKHNMQVSDPRRQWPISVLLQVLDELSQETPNDLLARELWCQAGNAAEWRQSVRRFVRCM 2090
            | ||:||                 ::|.:...:.|..:.|:|.||.::.::..|.:....:.|.:
plant  2187 L-PLIAK-----------------VEVFEYALENTEGNDLSRVLWLKSRSSEVWLERRTNYTRSL 2233

  Fly  2091 SVMSMIGYVIGLGDRHLDNVLINLGSGDIVHIDYNVCFEKGRTL-RIPEKVPFRLTQNLVQAMGI 2154
            :||||:||::||||||..|::::..||.|:|||:..|||..... :.|||||||||:.||:||.:
plant  2234 AVMSMVGYILGLGDRHPSNLMLHRYSGKILHIDFGDCFEASMNREKFPEKVPFRLTRMLVKAMEV 2298

  Fly  2155 TGIEGPFRLGCEYVLKVMRKERETLLTLLEAFVYDPLVDWTTNDDAQALRRSLNAKLQESADGGG 2219
            :||||.||..||.|::|:|..:::::.::||||:|||::|...:..:..:.:|......:|.
plant  2299 SGIEGNFRSTCENVMQVLRTNKDSVMAMMEAFVHDPLINWRLFNFNEVPQLALLGNNNPNAP--- 2360

  Fly  2220 AGGLGVGDLKYHKKDKNKGKPLDSDVKRQPFLSKLGMLQKYWSTNKTELMPQLEEMEQEVGNLQA 2284
                  .|::..::|::   |.|.|:.:                      ||....|:|:
plant  2361 ------ADVEPDEEDED---PADIDLPQ----------------------PQRSTREKEI----- 2389

  Fly  2285 AQAKQVVAEEELVKLNQRSALIAEIKSLGTAIESHSFNTASLRNAVRRGHSEALALLSTERLPDF 2349
            .||..::.:...| ||:|:.::  :..:...:....|:::::.:.....|:..|.
plant  2390 LQAVNMLGDANEV-LNERAVVV--MARMSHKLTGRDFSSSAIPSNPIADHNNLLG---------- 2441

  Fly  2350 GRVQCILRSYGQCLQLYHLLDLQGQLVKLQMESNS-EN 2386
                      |...::.|.|.::.|:.||..::.| ||
plant  2442 ----------GDSHEVEHGLSVKVQVQKLINQATSHEN 2469

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nonC	NP_001284967.1	SMG1	571..1140	CDD:292413	133/684 (19%)
		Rapamycin_bind	1738..1845	CDD:285924	27/128 (21%)
		PIKKc_SMG1	1894..2196	CDD:270714	107/302 (35%)
		FATC	3189..3217	CDD:280430
TOR	NP_175425.2	HEAT_EZ	185..233	CDD:404407
		TEL1	271..2481	CDD:227365	528/2638 (20%)
		HEAT repeat	575..603	CDD:293787	3/27 (11%)
		HEAT repeat	612..642	CDD:293787	5/29 (17%)
		HEAT repeat	650..680	CDD:293787	4/35 (11%)
		HEAT repeat	693..727	CDD:293787	6/33 (18%)
		HEAT repeat	739..769	CDD:293787	8/30 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D26975at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11139
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010