DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment nonC and TRRAP

DIOPT Version :9

Sequence 1:NP_001284967.1 Gene:nonC / 31625 FlyBaseID:FBgn0263968 Length:3218 Species:Drosophila melanogaster
Sequence 2:NP_001362453.1 Gene:TRRAP / 8295 HGNCID:12347 Length:3873 Species:Homo sapiens


Alignment Length:2368 Identity:415/2368 - (17%)
Similarity:754/2368 - (31%) Gaps:842/2368 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   268 IFIVVSNTLVQFAASYAETFECHFT------------DVVDIVIGWQLEAGQPTDLKTHCAQVLE 320
            ::..|.:.|||...|..:  ...||            |:.::||.|:|:            ::.:
Human  1980 VYYPVRHHLVQHMVSAMQ--RLGFTPSVTIEQRRLAVDLSEVVIKWELQ------------RIKD 2030

  Fly   321 QLTPFFSKQIDFSYGLLDQFVEDI-TTLEEGEPANTAERVGAFVGAFNTLLKCLARMQIFVGMPT 384
            |     ....|.......:.|..: ::::.|...::|:.|..|..|...:.....|.|   .:|.
Human  2031 Q-----QPDSDMDPNSSGEGVNSVSSSIKRGLSVDSAQEVKRFRTATGAISAVFGRSQ---SLPG 2087

  Fly   385 CECIVKMAVD---------HLIKIMPTLHLNTEALVNINELI---CICLLNNFTGLDPIL--LEQ 435
            .:.::...:|         .||::...::.||....:..|::   |:.||.  |.|.|.:  ..:
Human  2088 ADSLLAKPIDKQHTDTVVNFLIRVACQVNDNTNTAGSPGEVLSRRCVNLLK--TALRPDMWPKSE 2150

  Fly   436 VLLDQVKRMISLTELQRQSVLYLLLCTVRRLRARLTPSLVHFIFQSNPYMTKVRLRSPGETSYKL 500
            :.|....:::...| |...|.|..:||                               |......
Human  2151 LKLQWFDKLLMTVE-QPNQVNYGNICT-------------------------------GLEVLSF 2183

  Fly   501 LLRTCQETLLIRNVPLLQQAYKYLVDDIDACLEKLLITAPRSKARKASVLLVFHLSALAALAKQT 565
            ||...|.       |.:..::|.|...|.||:     |...:|..:|...|:..|.::......|
Human  2184 LLTVLQS-------PAILSSFKPLQRGIAACM-----TCGNTKVLRAVHSLLSRLMSIFPTEPST 2236

  Fly   566 SSIIG-------MYACKPSILELLLTNCRAHELKFWSKYPAAQQA----IFGLLVV---HCQANH 616
            ||:..       :||....::...|||           |..|..|    :||.|::   .|..|.
Human  2237 SSVASKYEELECLYAAVGKVIYEGLTN-----------YEKATNANPSQLFGTLMILKSACSNNP 2290

  Fly   617 NF--RTNSSLLRD-QELSAENTSPTANSFASIL----------------------------RFLD 650
            ::  |..|..:|. |::..|:.:|.|.|.::..                            .|:.
Human  2291 SYIDRLISVFMRSLQKMVREHLNPQAASGSTEATSGTSELVMLSLELVKTRLAVMSMEMRKNFIQ 2355

  Fly   651 SVLGQAHQLAPQN------LRVLLQWIQ----MLLRE---CREKIDLLMEQENF----------- 691
            ::|....:.:|..      ::::.:|::    |...:   .|||..||::...:           
Human  2356 AILTSLIEKSPDAKILRAVVKIVEEWVKNNSPMAANQTPTLREKSILLVKMMTYIEKRFPEDLEL 2420

  Fly   692 --------RGICRNIAATAS----KLVP--LESAACIQ--------TVLDYGLERLEKYPKLLIL 734
                    ..:.|:...:.|    ||.|  |....|.|        .|.|..::| ..|.:||.:
Human  2421 NAQFLDLVNYVYRDETLSGSELTAKLEPAFLSGLRCAQPLIRAKFFEVFDNSMKR-RVYERLLYV 2484

  Fly   735 YRDTALQQLQMLSTNYHAPYFQIYAQLPLHLTLTGGESSMPGMAS-------------------- 779
                      ..|.|:.|.....:.:..:.|.|...|.|.|...|                    
Human  2485 ----------TCSQNWEAMGNHFWIKQCIELLLAVCEKSTPIGTSCQGAMLPSITNVINLADSHD 2539

  Fly   780 RRVSVWQQRISQYSAVRDN-------VFRDF----FDRVQKPE-------------------QDS 814
            |........:.|....|:|       |..|.    .|:...|:                   .|.
Human  2540 RAAFAMVTHVKQEPRERENSESKEEDVEIDIELAPGDQTSTPKTKELSEKDIGNQLHMLTNRHDK 2604

  Fly   815 LIHCLREL--------FVRSCQVAPQDERQMNLSQCTKRCQRLAIAWLQFEAARYCVDQRLRTTV 871
            .:..|||:        ||:.|.::      ..|::.|         |:|       :..||...:
Human  2605 FLDTLREVKTGALLSAFVQLCHIS------TTLAEKT---------WVQ-------LFPRLWKIL 2647

  Fly   872 GKPQETFLGFEAIIMRHARLLSGCAKEIERSALDDLSLEELLSMQSNLSLLLGFLDALEKLIYNA 936
            ...|:..|..|.     :..|...:.:::|..              ..|.|..|::|:.:.:   
Human  2648 SDRQQHALAGEI-----SPFLCSGSHQVQRDC--------------QPSALNCFVEAMSQCV--- 2690

  Fly   937 AEGSAFALRPPEKQVAAFFRLNNPTCQSWFNRIRIGVVI--------IAMHVQQPELVIRYAQQI 993
                     ||........:....|...||   |..:::        :::.: :|:....:.:|.
Human  2691 ---------PPIPIRPCVLKYLGKTHNLWF---RSTLMLEHQAFEKGLSLQI-KPKQTTEFYEQE 2742

  Fly   994 LVNSKTQDPTYSQAIVYMAWSLVSCQEADSLRGLRLWARGKSCKSYKWLKYAADQAAGKRESALA 1058
            .:....|:...|.|.:|   ||:  ||.|...|  ||.  |.||..:.....|.:..|..|.|..
Human  2743 SITPPQQEILDSLAELY---SLL--QEEDMWAG--LWQ--KRCKYSETATAIAYEQHGFFEQAQE 2798

  Fly  1059 GYRTILAEKELQSELEPHTR-----------QFVVSQMMQCLQDLGQWSQLVELKQQQMTRPEDR 1112
            .|     ||.:....:.|.|           |......::|.::|.||..|.|..|.:      .
Human  2799 SY-----EKAMDKAKKEHERSNASPAIFPEYQLWEDHWIRCSKELNQWEALTEYGQSK------G 2852

  Fly  1113 ELNPFL------QRSNVEVNALERLLAKSEESCSSMDALGGVFQQLSLWPSNWDESVSSSGLSER 1171
            .:||:|      :.||  ..|::..|.:.|.||....|          |..|          ..|
Human  2853 HINPYLVLECAWRVSN--WTAMKEALVQVEVSCPKEMA----------WKVN----------MYR 2895

  Fly  1172 ASFSSIHMRQRTEDIVLHKLLEDRCVPDQAKNLLDTQWRDSLLNPSFDQRSCKELTLLRHIVQGV 1236
            ...:..|..::....:      :|.| :.|.:|...:||                 .|.|:|..|
Human  2896 GYLAICHPEEQQLSFI------ERLV-EMASSLAIREWR-----------------RLPHVVSHV 2936

  Fly  1237 -----SGGQEL-----------SLLPVSSGR-------------CQNRSKFIS------SAILMR 1266
                 ...|::           .|.|.:.||             .:||...:|      |:|.| 
Human  2937 HTPLLQAAQQIIELQEAAQINAGLQPTNLGRNNSLHDMKTVVKTWRNRLPIVSDDLSHWSSIFM- 3000

  Fly  1267 CLAWTQ-----------LLRQHCAPGSWETLCLDAAAA--------AREEGNLQLAETLLTQFFG 1312
               |.|           ...||....:...|.:.|:|:        ||::|.:.:|..:|::...
Human  3001 ---WRQHHYQAIVTAYENSSQHDPSSNNAMLGVHASASAIIQYGKIARKQGLVNVALDILSRIHT 3062

  Fly  1313 QPIGEIAALF-SLEQ---------GVQTDNPEMLRGYSELVKCLHL----QQQQSQTHS------ 1357
            .|...|...| .:.|         ||...| |.::|. |:::..:|    ::..::.::      
Human  3063 IPTVPIVDCFQKIRQQVKCYLQLAGVMGKN-ECMQGL-EVIESTNLKYFTKEMTAEFYALKGMFL 3125

  Fly  1358 GDLSSSIDVCAALCLNIQKSNNQPAAGA---DLLLNLADWIAVRTCNGLTTNQSPVLIQLLDQLP 1419
            ..::.|.:...|....:|..:....|.|   |.|.|:  ::..|              ||  .|.
Human  3126 AQINKSEEANKAFSAAVQMHDVLVKAWAMWGDYLENI--FVKER--------------QL--HLG 3172

  Fly  1420 ECPLTCDSSQPLAIPQAERMVARLVHSCLQQRPNYAEALIAYGNWCYRWGKKVADSCCVLTQADA 1484
            ...:||                 .:|:|..|..:.:...:|...|...:            ..|.
Human  3173 VSAITC-----------------YLHACRHQNESKSRKYLAKVLWLLSF------------DDDK 3208

  Fly  1485 TAISQALDIPQPLESEKLDELLQALSTEQPPANCVEVCPDAARARDDEAAKNRLRRLTFLADKTP 1549
            ..::.|:|                       ..|:.|.|              ::.|.::    |
Human  3209 NTLADAVD-----------------------KYCIGVPP--------------IQWLAWI----P 3232

  Fly  1550 EALDAIL----QIWRRAIANTYDYYKDAARSYFQ----YLS--------FKSGSGPEKPEGEGVV 1598
            :.|..::    ::....|:.....|..|.  ||.    ||:        :||.||.::|...|..
Human  3233 QLLTCLVGSEGKLLLNLISQVGRVYPQAV--YFPIRTLYLTLKIEQRERYKSDSGQQQPSSVGNQ 3295

  Fly  1599 SQRERLHVDDSNLVTTTLRLLRLI-VKHASGLQEVLEQGLHTTPIAPWKVIIPQL-FSRLNHHEP 1661
            |.    ...|...:..|..:.|.. :.|       :::.||.|.::..:.|:.|: :.|.|.||.
Human  3296 SH----SASDPGPIRATAPMWRCSRIMH-------MQRELHPTLLSSLEGIVDQMVWFRENWHEE 3349

  Fly  1662 YVRKSVCDLLCRLAKSRPQLVIFPAVVGANREQQDATAPPATARPTTEDACCYGYLLGELSKQAP 1726
            .:|:    |...|||                                    ||     .::.:..
Human  3350 VLRQ----LQQGLAK------------------------------------CY-----SVAFEKS 3369

  Fly  1727 EAVQHVKLMVKELRRVCLLWDEYWIHSLAHIYNTYVSRVSALATDFRPDDHEGKNNRFNVWRPQL 1791
            .||...|:....|.         ::..|...:...:..||.::|.|.....|             
Human  3370 GAVSDAKITPHTLN---------FVKKLVSTFGVGLENVSNVSTMFSSAASE------------- 3412

  Fly  1792 LADLEALVAVTSRPPETTYERSFRK---------RFDAPIRLTVDALRHRRYPEAWDKL-----K 1842
                    ::..|...|..:..|:|         .|..|..:.:..|..:.  :.|.|:     |
Human  3413 --------SLARRAQATAQDPVFQKLKGQFTTDFDFSVPGSMKLHNLISKL--KKWIKILEAKTK 3467

  Fly  1843 QL--YHILQ------SNMIRGSGSTLKMQSISPVLCGIGRMRISMPGLDAHGPDGDQVYIE---- 1895
            ||  :.:::      ||.   |..|.:               :.:|| :...|.....||:    
Human  3468 QLPKFFLIEEKCRFLSNF---SAQTAE---------------VEIPG-EFLMPKPTHYYIKIARF 3513

  Fly  1896 --SVESSVCVLPTKTKPKKVAFYGSNGQRYTFLFKGMEDLHL-----DERIMQFLSISNAIMACR 1953
              .||   .|....|..:::...|.||:.|.:|.  |.|..|     :||::|.|.:.|..:..|
Human  3514 MPRVE---IVQKHNTAARRLYIRGHNGKIYPYLV--MNDACLTESRREERVLQLLRLLNPCLEKR 3573

  Fly  1954 SDAPGNGCYRAHHYSVIP----LGPQSGLISWVDGVTPVFALYKKWQQRRSQVAGNAGAGAVANV 2014
            .:..     :.|.:..:|    :.||..|:........:..:||       |.....|......:
Human  3574 KETT-----KRHLFFTVPRVVAVSPQMRLVEDNPSSLSLVEIYK-------QRCAKKGIEHDNPI 3626

  Fly  2015 PRRFTDLFYNKLSPLLAKHNMQVSDPRRQWPISVLLQVLDELSQETPNDLLAREL---WC--QAG 2074
            .|     :|::|:.:.|: ..|.|.           |||.::.:|..::::.|.:   |.  ...
Human  3627 SR-----YYDRLATVQAR-GTQASH-----------QVLRDILKEVQSNMVPRSMLKEWALHTFP 3674

  Fly  2075 NAAEWRQSVRRFVRCMSVMSMIGYVIGLGDRHLDNVLI--NLGSGDIVHIDYNVCFEKGRTLRIP 2137
            ||.::....:.|...::::....:|:.|...:.:.:.|  :.|..::.:..:::....| .|...
Human  3675 NATDYWTFRKMFTIQLALIGFAEFVLHLNRLNPEMLQIAQDTGKLNVAYFRFDINDATG-DLDAN 3738

  Fly  2138 EKVPFRLTQNLVQAMGITGIEGPFRLGCEYVLKVMRKERETLLTLLEAFVYDPLVDWTTNDDAQA 2202
            ..||||||.|:.:.:...|:.||.......|.:...:....:..:|:..:.|.::.|        
Human  3739 RPVPFRLTPNISEFLTTIGVSGPLTASMIAVARCFAQPNFKVDGILKTVLRDEIIAW-------- 3795

  Fly  2203 LRRSLNAKLQESADGGGAGGLGVGDLKYHKKDKN--------KGKPLDSDVKRQPFLSKLGMLQK 2259
                                        |||.:.        .|:|.:.|.::     .:.::||
Human  3796 ----------------------------HKKTQEDTSSPLSAAGQPENMDSQQ-----LVSLVQK 3827

  Fly  2260 YWSTNKTEL--MPQLEEMEQEVGNLQAA 2285
            ..:...|.|  :.|.|..|.:|..|.||
Human  3828 AVTAIMTRLHNLAQFEGGESKVNTLVAA 3855

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nonCNP_001284967.1 SMG1 571..1140 CDD:292413 133/735 (18%)
Rapamycin_bind 1738..1845 CDD:285924 19/122 (16%)
PIKKc_SMG1 1894..2196 CDD:270714 63/323 (20%)
FATC 3189..3217 CDD:280430
TRRAPNP_001362453.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 491..541
Interaction with TP53. /evidence=ECO:0000269|PubMed:12138177 2017..2395 78/454 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2030..2051 3/25 (12%)
Bipartite nuclear localization signal. /evidence=ECO:0000255 2054..2069 3/14 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2550..2585 7/34 (21%)
TEL1 <2552..3873 CDD:227365 299/1706 (18%)
FAT 2868..3200 CDD:367004 73/418 (17%)
PIKK_TRRAP 3510..3797 CDD:270707 62/357 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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