DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nonC and Pi4kb

DIOPT Version :9

Sequence 1:	NP_001284967.1	Gene:	nonC / 31625	FlyBaseID:	FBgn0263968	Length:	3218	Species:	Drosophila melanogaster
Sequence 2:	XP_038959158.1	Gene:	Pi4kb / 81747	RGDID:	621214	Length:	862	Species:	Rattus norvegicus

Alignment Length:	784	Identity:	144/784 - (18%)
Similarity:	245/784 - (31%)	Gaps:	279/784 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  1590 EKPEGE-GVVS------QRER----------LHVDDSNLVTTTLRLLRLIVKHASGLQEVLEQGL 1637
            |:.|.| ||||      :|.|          |.:.:|.|...::.:..|......|:|..:...|
  Rat   125 EEDEMEPGVVSGTAKGTRRRRQNNSAKQSWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRL 189

  Fly  1638 HTTPIAPWKVIIPQLFSRLNHHE--------PYV----RKSV-----CDLL-------------- 1671
            ...........:|||.:...|.:        ||:    |:|:     |.||
  Rat   190 FCFRNEDVDFYLPQLLNMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQR 254

  Fly  1672 -CRLAKSRPQLVIFPAVVGANREQQDATAPPA----------TARPTTEDACCYGYLLGELSKQA 1725
             .|..|.| :|::...:..|:|:::..|..||          |.:.:..||.....|...|.:.|
  Rat   255 HSRGTKLR-KLILSDELKPAHRKRELPTLSPAPDTGLSPSKRTHQRSKSDATASISLSSNLKRTA 318

  Fly  1726 --PEAVQHVKLMVKELRRVCLLWDEYWIHSLAHIYNTYVS-------------------RVSALA 1769
              |:....               ||....|...|.|::.|                   |::.|.
  Rat   319 SNPKVENE---------------DEELSSSTESIDNSFSSPVRLAPEREFIKSLMAIGKRLATLP 368

  Fly  1770 TDFRPDDHEGKNNRF-------------NVWRPQLLAD--------LEALVAVT-SRPPETTYER 1812
            |      .|.|..|.             .||.|....|        .:|:|..: .:.|...|..
  Rat   369 T------KEQKTQRLISELSLLNHKLPARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVE 427

  Fly  1813 SFR-KRFD---APIRLTVDALRHRR----YPEAWDKLKQLYHILQSNMIRGSGSTL-------KM 1862
            ... :.||   .|.|:..:.:|..|    .||..         :......||.||:       :.
  Rat   428 VLECENFDTTNVPARIPENRIRSTRSVENLPECG---------ITHEQRAGSFSTVPNYDNDDEA 483

  Fly  1863 QSISPVLCGIGRMRISMPGLDAHGPDGDQVYIESVESSVCVLPTKTKPKKVAFYGSNGQRYTFLF 1927
            .|:.    .||.:::.:|  :.|....|.:...||:|.     |..:.|:..|..:...|
  Rat   484 WSVD----DIGELQVELP--EVHTNSCDNISQFSVDSI-----TSQESKEPVFIAAGDIR----- 532

  Fly  1928 KGMEDLHLDERIMQFLSISNAIMACRSDAPGNGCYRAHHYSVIPLGPQSGLISWVDGVTPVFALY 1992
                 ..|.|::                        ||..:.....|:.         ....||.
  Rat   533 -----RRLSEQL------------------------AHTPTAFKRDPED---------PSAVALK 559

  Fly  1993 KKWQQRRSQVAGNAGAGAVAN----------------------VPRRFTDLFYNKLSPLLAK--- 2032
            :.||::..::...:..|.:.|                      |.::...::..:..||..|
  Rat   560 EPWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYK 624

  Fly  2033 ---------------HNMQVSDPRRQWPISVLLQVLDELSQETPNDLLARELWCQAGNAAEWRQS 2082
                           :.:.:...::|..:|:|...|.|....|....|:.:
  Rat   625 ILVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQ-------------- 675

  Fly  2083 VRRFVRCMSVMSMIGYVIGLGDRHLDNVLINLGSGDIVHIDYN-VCFEKGRTLRIPEKVPFRLTQ 2146
             |.||:..:...::.|::.:.|||..|:|:: ..|.|:|||:. :.....|.|.. |...|:||.
  Rat   676 -RNFVQSCAGYCLVCYLLQVKDRHNGNILLD-AEGHIIHIDFGFILSSSPRNLGF-ETSAFKLTT 737

  Fly  2147 NLVQAMGITGIEGP----FRLGCEYVLKVMRKERETLLTLLEAFVYDPLVDWTTNDDAQALRRSL 2207
            ..|..||  |:.|.    :::.....|...||..:.::.::|..             .|..||..
  Rat   738 EFVDVMG--GLNGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIM-------------QQGCRRCS 787

  Fly  2208 NAKL 2211
            .|.|
  Rat   788 GASL 791

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nonC	NP_001284967.1	SMG1	571..1140	CDD:292413
		Rapamycin_bind	1738..1845	CDD:285924	28/155 (18%)
		PIKKc_SMG1	1894..2196	CDD:270714	58/346 (17%)
		FATC	3189..3217	CDD:280430
Pi4kb	XP_038959158.1	PI4KB_NTD	27..91	CDD:412074
Pi4kb	XP_038959158.1	PI4Kc_III_beta	554..862	CDD:270712	51/270 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900