DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nonC and pi4kab

DIOPT Version :9

Sequence 1:	NP_001284967.1	Gene:	nonC / 31625	FlyBaseID:	FBgn0263968	Length:	3218	Species:	Drosophila melanogaster
Sequence 2:	NP_001106813.1	Gene:	pi4kab / 793349	ZFINID:	ZDB-GENE-080220-34	Length:	1099	Species:	Danio rerio

Alignment Length:	1057	Identity:	183/1057 - (17%)
Similarity:	344/1057 - (32%)	Gaps:	368/1057 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 PVVQNHRKAYQCKGDTINP------------------MANGEDLRLSKIIRRLINENNPTVSLEL 150
            |..|....:|..:|..:||                  .|:|.::               .|.|||
Zfish   224 PGPQYFEGSYLSEGSAVNPDYYFTTVSSSFSMSPLFSGASGPEI---------------NVPLEL 273

  Fly   151 CSKLDQAVRTPINMGYMTCSFVWILDNMLTLYKQCPPPVLEECSKTLGLIGFINRKSYPIYEEFI 215
            ..:|.|.|:.     :::.||:..||.::|          |......|:..|....|.|:|..
Zfish   274 LRRLLQMVKQ-----FVSDSFLKSLDAVVT----------EVTEANAGVDLFYKGFSDPLYVS-- 321

  Fly   216 VKNYKSSKRMQKYMIMALRATLSCDTKCELHMYADKIMLLLKDFLENAESADIFIVVSNTLVQFA 280
                         |...||.||.                    ::::..:..:..|....|.||:
Zfish   322 -------------MFKMLRDTLY--------------------YMKDVHAGFVKEVHDFVLEQFS 353

  Fly   281 ASYAE-----------------TFECHFTDV-VDIVIGWQLEAGQPTD-LKTHCAQVLEQLTPFF 326
            :|.:|                 ...||.... ||::: |.::..|..: |.|..::.|:..|.
Zfish   354 SSQSELQRVLHEERLPGEASPLKLRCHANAACVDLMV-WAVKDEQGAENLCTKLSEKLQSKTS-- 415

  Fly   327 SKQIDFSYGLLDQFVEDITTLEEGEP--ANTAERVGAFVGAFNTLLKCLARMQIFVGMPTCECIV 389
            ||.|.....||...::.:..|.|..|  |::|.                ..::.|:.:|:. .::
Zfish   416 SKVIIAHMPLLICCLQGLGRLCERFPVIAHSAS----------------LSLKDFLVVPSA-VLI 463

  Fly   390 KMAVDHL--------IKIMPTLHLNTEALVNINEL--------------------ICICLLNNFT 426
            |:...|.        |||..|   |..:..::|.|                    ||.||....|
Zfish   464 KLYKYHSQCSSGAGGIKINVT---NEHSQSSLNLLSSRKDQPSMYEQLRDISIDNICRCLKAGLT 525

  Fly   427 GLDPILLEQVLLDQVKRMISLTELQRQSVLYLLLCTVRRL-----RARLTPSLVHFIFQSNPYMT 486
             :||:::|..|.....|:....|..:::.| :...|:|.|     ..|.:|.::..|.|.
Zfish   526 -MDPVIVEAFLASLSNRLYISQENDKEAHL-IPDHTIRALGHIAVAMRDSPKVMEPILQI----- 583

  Fly   487 KVRLRSPGETSYKLLLRTCQ-----ETLLIRNVP-LLQQAYKYLVDDIDACLEKLLITAPR---- 541
                         |..:.||     :.|:|..:. ::....:|:..::....:::.:.|..
Zfish   584 -------------LQQKFCQPPSPLDVLIIDQLGCMIITGNQYIYQEVWNLFQQISVKASNVVYS 635

  Fly   542 -SKARKASVLLVFHLSALAALAKQTSSIIGMYACKPSILELLLTNCRAHELKFWSKYPAAQQAIF 605
             :|..|........|:.:.|||...:::.|    :|.:.|||:
Zfish   636 ATKDYKDHGYRHCSLAVINALANIAANLQG----EPLVDELLV---------------------- 674

  Fly   606 GLLVVHCQANHNFRTNSSLLRDQ--ELSAENTSPTANSFASILRFLDSVLGQAHQLAPQNLRVLL 668
            .||.:..|.....:.......|:  .|.|.:::........::..|...|....:..|: |:.|.
Zfish   675 NLLELFVQLGLEGKRACERASDKGPALKASSSAGNLGVLIPVIAVLTRRLPPIKEAKPR-LQKLF 738

  Fly   669 Q--WIQMLLRECREKIDLLMEQENFRGICRNIAATASKLVPLESAACIQTVLDYG---------- 721
            :  |:..::.....:...|..:|.:.|:|.  .||.|.|:...|...:::.|.|.
Zfish   739 RDFWLYSVVMGFAVEGSGLWPEEWYEGVCE--IATKSPLLTFPSGEPLRSELQYNSALKNDTVTP 801

  Fly   722 ----------LERLEKYPK---------------LLILYRDTALQQLQMLSTNYHAPYFQIYAQL 761
                      :..|:..|:               ||.:||   |:.::||.:| .|..||:
Zfish   802 AELSDLRSTIINLLDPSPEAAALINKLDFAMCTYLLSVYR---LEYMRMLHSN-DADRFQV---- 858

  Fly   762 PLHLTLTGGESSMPGMASRRVSVWQQRISQYSAVRDNVFRDFFDRVQKPEQDSLIHC-------L 819
                                                 :||.|.|:..:.::..::.|       :
Zfish   859 -------------------------------------MFRYFEDKAIQKDKSGMMQCVICVGDKV 886

  Fly   820 RELFVRSCQVAPQDERQ------------MNLSQCTKRCQRLAIAWLQFEAARY----------- 861
            .|:|::.....|:.:..            :|.:...||.:|:|..:|...|..:
Zfish   887 FEVFLQMMAEKPKTKEHEEELERHAQFLLVNFNHTHKRIRRVADKYLSGLAETFPHLLWSGRVLK 951

  Fly   862 -------CVDQRLRTTVGKPQ---------------ETFLGFEAIIMRHARLLSGCAKEIER--S 902
                   .:...|...:.|.|               :|....|:|:...|.......||..:  :
Zfish   952 TMLDILQTLSLSLSADIHKDQPYYDIPDTPYRITVPDTHEARESIVKDFAARCGEILKEAMKWAA 1016

  Fly   903 ALDDLSLEELLSMQSN----LSLLLGFLDALEKLI----YNAAEGSAFALRPPEKQVAAFFRLNN 959
            ::....|:|.|:...|    ||...|...|.|.::    || .:.:...:...|:....|.:: .
Zfish  1017 SVTKSHLQEYLNKHQNWLSGLSQHTGLAMATESILNFAGYN-RQSTTLGMMVSERVTEVFVQM-K 1079

  Fly   960 PTCQSWFNRIRIGVVII 976
            .:|.|..:|..:|.:|:
Zfish  1080 VSCSSLISRHTVGELIM 1096

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nonC	NP_001284967.1	SMG1	571..1140	CDD:292413	82/507 (16%)
		Rapamycin_bind	1738..1845	CDD:285924
		PIKKc_SMG1	1894..2196	CDD:270714
		FATC	3189..3217	CDD:280430
pi4kab	NP_001106813.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900