DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nonC and Atr

DIOPT Version :9

Sequence 1:	NP_001284967.1	Gene:	nonC / 31625	FlyBaseID:	FBgn0263968	Length:	3218	Species:	Drosophila melanogaster
Sequence 2:	XP_003750609.1	Gene:	Atr / 685055	RGDID:	1305796	Length:	2636	Species:	Rattus norvegicus

Alignment Length:	2366	Identity:	492/2366 - (20%)
Similarity:	818/2366 - (34%)	Gaps:	754/2366 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   241 TKCELHMYADKIMLLLKDFLENAESADIFIVVSNTL-VQFAASYAE---TFECHFTDVVDIVIG- 300
            |...|..|. |::...|..||:.:..::.:|:.:.: :..|..|.:   :|:.|   |::.:.|
  Rat   536 TWMSLDFYT-KVLKSCKSLLESVQKHELELVIDSVVRIYDALMYIQVKSSFQDH---VLEELCGM 596

  Fly   301 ----WQLEAGQPTDLK--THCAQVL-------EQLTPFFSKQIDFSYGLLDQ--FVEDITTLEEG 350
                |.........||  |....:|       |..:|....|..|...|..:  |::..||:
  Rat   597 LSLPWIYSYSDDNSLKMTTFATNLLRLSQRVWESYSPQAQSQCVFLLTLFPKRIFLDWRTTV--- 658

  Fly   351 EPANTAERVGAFVGAFNTLLK---------CLARMQIFVGMP-TCECIVKMAVD------HLIK- 398
                           :|..||         |:....|.:... :|..|.||.:|      |::|
  Rat   659 ---------------YNWALKSSHEVIRTSCVKGFFILLQQENSCNQIPKMLIDRVKDDSHVVKK 708

  Fly   399 --------IMPTLH-------LNTEALVNINELICICLLNNFTGLDPILLEQVLLDQVKRMISLT 448
                    ::.|||       .:.|......:|.|       ..|......:....|||..:.
  Rat   709 EFASVLGQLVCTLHGMFYLTSSSVEPFFGPVDLFC-------KNLKATSQHECSSSQVKASVC-- 764

  Fly   449 ELQRQSVLYLLLCTVRRLRARLTPSLV-------------HFIFQSNPYMTK------------- 487
                :..|:||        .:.|||.|             |..||.:....|
  Rat   765 ----KPFLFLL--------TKNTPSPVKLAFIDNLHHLCKHLDFQEDETEVKAVLGTLLNLMEDP 817

  Fly   488 ---VRLRSPGETSYKLLLRTCQETLLIRNVPLLQQAYKYLVDDIDACLE----KLLITAPRSKAR 545
               ||:...|...| :|.....|...|:.:.:|:....|....|....|    .:|.|....:|.
  Rat   818 DKDVRIAFSGNIKY-ILESLNSEDGFIKELFVLRMKEAYTHAQISRSNELKDTLILTTGDIGRAA 881

  Fly   546 KASVLLVFHLSALAALAKQTSSIIGMYACKPSILELLLTNCRAHELK---FWSKY--PAAQQAIF 605
            |..::....|..|..|..:::|:.|  |....|..|:    .|..:|   |:|:|  |..|..:.
  Rat   882 KGDLIPFALLHLLHCLLSKSASVSG--AAYTEIRALV----AAKSVKLQNFFSQYKKPICQFLVE 940

  Fly   606 GLLVVHCQANHNFRTNSSLLRDQ------ELSAENTSPTAN--SFASILRFLDSVL--------G 654
            .|......|..:....::.:|.|      |::....|..||  .|..:.|||...|        .
  Rat   941 SLHSSQMTALPSTPCQTAEMRKQHVAHHREMALNTLSEIANVFDFPDLNRFLTRTLQVLLPDLAA 1005

  Fly   655 QAHQLAPQNLRVLLQWIQMLLRE----------------CRE--------------KIDL--LME 687
            :|...|...:|.|.:.:.:..||                |.:              :|:|  |:.
  Rat  1006 KASPAASALIRTLGKQLNVNRREILINNFKYIFSHLVCSCSKDELERALHYLKNETEIELGSLLR 1070

  Fly   688 QENFRGICRN------------------IAATASKLVPLESAACI---QTVLDYGLERLEKYPKL 731
            |: |:|:...                  :|:.||...|.:....|   :.:.||      ..|||
  Rat  1071 QD-FQGLHNELLLRIGEHYQQVFNGLSILASFASSDDPYQGPRDITSPELMADY------LQPKL 1128

  Fly   732 L-ILYRDTALQQLQMLSTNYHAPYFQIYAQLPLHLTLTGGESSMPGMASRRVSVWQQRISQYSAV 795
            | ||    |...:|:||::....        ...:.||...|.|..|..:.||  ..|:...:.:
  Rat  1129 LGIL----AFFNMQLLSSSVGIE--------DKKMALTSLMSLMKLMGPKHVS--SVRVKMMTTL 1179

  Fly   796 RDNV-FRDFFDRVQKPEQDSLIHCLRELF------------------------------VRSCQV 829
            |..: |:|.|..:.....|..:.||...:                              :...:|
  Rat  1180 RTGLRFKDDFPELCCRAWDCFVRCLDHAYLGPLLSHVIVALLPLIQMQPKETAAIFHYLIIENRV 1244

  Fly   830 APQD----------------------ERQMNLSQCT--KRCQRLAIAWLQFEAARYCVDQR---- 866
            |.||                      |.:...|:.|  :...:|::..:|.|.    ||.|
  Rat  1245 AVQDFLHEIYFLPDHPELEKIKAVLQEYRKETSESTDLQTTLQLSMKAIQHEN----VDVRIHAL 1305

  Fly   867 --LRTTVGKPQETFLGF-------EAIIMR--------------HARLLSG-CAKEIERSALD-- 905
              |:.|:.|.||..:.:       |.:|.:              .||||.| |..|:  .|:|
  Rat  1306 TSLKETLYKNQEKLIKYATDSETVEPVISQLVTVILKGCQDANSQARLLCGECLGEL--GAIDPG 1368

  Fly   906 --DLSLEE-------LLSMQSNLSLLLGFLDALEK--LIY----NAAEGSAFALRPPEKQVAAFF 955
              |.|..|       .::...:||...|.|..|.:  |.|    .|.:.:|:|:    :::.:.:
  Rat  1369 RLDFSTTETQGKDFTFVTGVEDLSFAYGLLMELTRAYLAYADNSRAQDSAAYAI----QELLSIY 1429

  Fly   956 -----RLNNPTCQSWFNRIRIGVVIIAMHVQ---QPELVIRYAQQILVNSKTQDPTYSQAIVYMA 1012
                 :.|.|..|.|..        ...||:   :|.|..||..    :.|:.|
  Rat  1430 DCREMQSNGPGHQLWKR--------FPEHVREILEPHLNTRYKS----SQKSTD----------- 1471

  Fly  1013 WSLVSCQEADSLRGLRLWARGKSCK--SYKWLKYAADQAAGKRESALAGYRTILAEKELQSE--L 1073
            ||.|:       :.:.|...|.:..  |..|..|...:......|.:....:|:.:.:.:..  |
  Rat  1472 WSGVT-------KPIYLSKLGNNFAEWSSSWAGYLITKVRDNLASKIFTCCSIMMKHDFKVTIYL 1529

  Fly  1074 EPH------------TRQFVVSQMMQCLQDLGQW--------SQLVELKQQQMTRPEDRELNPFL 1118
            .||            .:|.|.:::|..|:...|.        |.|.:|..|.:....| .|..:.
  Rat  1530 LPHILVYVLLGCSQEDQQEVYAEIMAVLKHDDQHAISTQDSASDLCQLSTQTVFSMLD-HLTQWA 1593

  Fly  1119 QRSNVEVNALERLLAKSEESCSSM--DALGGVFQQLSLWPSNWDESVSSSGLSERASFSSIH--- 1178
            :.....:|| |:|.....:..||:  :....|.:.|.|.|.  |....:|..|:..:.:.:|
  Rat  1594 RHKFQALNA-EKLAQNKPKGVSSVNFEDYQSVTRFLDLIPQ--DTLAVASFRSKAYTRAVMHFES 1655

  Fly  1179 -MRQRTEDIVLH-----KLLEDRCVPD-----QAKNLLDTQWRDSLLNPSF-----DQRSCKELT 1227
             :.::.::|..|     ||......||     .|....:...::.:|....     |..:|.:..
  Rat  1656 FITEKKQNIQKHLGFLQKLYAAMHEPDGVAGVSAIRKAEPSLKEQILEHESIGLLRDATACYDRA 1720

  Fly  1228 L------LRH---IVQGVSG-GQELSLLPVSSGRCQNRSKFISSAILMRCLAWTQLLRQHCAPGS 1282
            :      :.|   :|:.:.| ||..:::...:|...|||:            ||..|..:....:
  Rat  1721 IQLEPDQIIHYHGVVKSMLGLGQLSTVITQVNGVHANRSE------------WTDELNTYRVEAA 1773

  Fly  1283 WETLCLD------AAAAAREEGNLQLAETLL-------TQFF-------GQPIGEIAALFSLEQG 1327
            |:....|      ||.......:::|.:.||       |.|:       .:.|..::|. |.|:|
  Rat  1774 WKLSQWDLVENYLAADGKSTTWSVRLGQLLLSAKKRDTTAFYDTLKLVRAEQIVPLSAA-SFERG 1837

  Fly  1328 VQTDNPEMLRGYSELVKCLHLQQQQSQTHSGDLSSSI---------DVCAALCLN----IQKSNN 1379
                  ...|||..:|: ||:        ..:|..|:         |.|....||    ::.:.|
  Rat  1838 ------SYQRGYEFIVR-LHM--------LCELEHSLKPLFHKFPGDSCNEDSLNWAARLEMTQN 1887

  Fly  1380 QPAAGADLLLNLADWIAVRTCNGLTTNQSPVLIQLLDQLPECPLTCDSSQPLAIPQAERMVARLV 1444
            ...|...:|       |:|... |:.|:.|   ...:.:.||.|           |:.|:..:..
  Rat  1888 SYRAKEPIL-------ALRRAL-LSLNKRP---DYNEMVGECWL-----------QSARVARKAG 1930

  Fly  1445 HSCLQQRPN---------YAEALIAYGNWCYRWGKKVADSCCVLTQADATAISQALDIPQ---PL 1497
            |.  |...|         .||..:....|.  |.|.......::.|...     .|..|:   |.
  Rat  1931 HH--QTAYNALLNAGESRLAELYVERAKWL--WSKGDVHQALIVLQKGV-----ELCFPENKSPT 1986

  Fly  1498 ESEKLDELLQALST------EQPPANCVEVCPDAARARDDEAAKNRLRRLT-FLADKTPEALDAI 1555
            ||:.:  |:...:|      .:..||.           :..|...:.:.:| ||    ||
  Rat  1987 ESKHM--LIHGRATLLVGRFMEETANF-----------ESNAIMKKYKDVTLFL----PE----- 2029

  Fly  1556 LQIWRRAIANTYDYYKDAARSYFQYLSFKSGSGPEKPEGEGVVSQRERLHVDDSNLVTTTLRLLR 1620
               |.       |.:...|:.|.:.:...:.:..|| :|:                      |:|
  Rat  2030 ---WE-------DGHFYLAKYYDKLMPMVTDNKMEK-QGD----------------------LIR 2061

  Fly  1621 LIVKHASGLQEVLEQGLHTTPIAPWKVIIPQLFSR-LNHHEPYVRKSVCDLLCRLAKSRPQLVIF 1684
            .||.|                           |.| |.:...::.:|:           |:::..
  Rat  2062 YIVLH---------------------------FGRSLQYGNQFIYQSM-----------PRMLSL 2088

  Fly  1685 PAVVGANREQQDATAPPATARPTTEDACCYGYLLGELSKQAPEAVQHVKLMVKELRRVCLLWDEY 1749
            ....||...:.:........:...:.|.....|....::.||  .|.:....:.:.|:|...||.
  Rat  2089 WLDFGAKAYEWEKGGRSDRLQMRNDLAKINSVLTEHTNRLAP--YQFLTAFSQLISRICHSHDEV 2151

  Fly  1750 WI---HSLAHIYNTYVSRVSALATDFRPDDHEGKNNRFNVWRPQLLADLEALVAVTSRPPETTYE 1811
            ::   ..:|.::..|..:...:.|......:..:.||..          |.|.....      .:
  Rat  2152 FVVLMEIIAKVFLAYPQQAMWMMTAVSKSSYPMRVNRCK----------EILTKAIH------MK 2200

  Fly  1812 RSFRKRFDAPIRLTVDALRHRRYPEAWDKLKQLYHILQSNMIRGSGSTLKMQ------------- 1863
            :|..|......|||             |||.:|.    :..:.||.|||.|.
  Rat  2201 KSLEKFVGDATRLT-------------DKLLELC----NKSVDGSNSTLSMSTHFKMLKKLVEDP 2248

  Fly  1864 SISPVLCGIGRMRI----SMPGLDA-HGP-DGDQVYIESVESSVCVLPTKTKPKKVAFYGSNGQR 1922
            :.|.:|..:..:.|    |:.|..| |.| .|...|:...:..|.:|.:..||||::..||:|:.
  Rat  2249 TFSEILIPLQSVMIPTLPSILGAHANHDPFPGHWAYLAGFDDVVEILSSLQKPKKISLKGSDGKF 2313

  Fly  1923 YTFLFKGMEDLHLDERIMQFLSISNAIMACRSDAPGNGCYRAHH---YSVIPLGPQSGLISWVD- 1983
            |..:.|..:||..|.|:|:|.|:.|  .:.|.||...  .|..|   |:||||..:.|:|.||:
  Rat  2314 YIMMCKPKDDLRKDCRLMEFNSLIN--KSLRKDAESR--RRELHIRTYAVIPLNDECGIIEWVNN 2374

  Fly  1984 --GVTPVFALYKKWQQRRSQVAGNAGAGAVANVPRRFTDLFYNKLSPLLAKHNMQVSDPRRQWPI 2046
              |:.|:                             .|.|:..|...:..|...|...|:.. .:
  Rat  2375 TAGLRPI-----------------------------LTKLYKEKGVYMTGKELRQCMLPKSA-AL 2409

  Fly  2047 SVLLQVLDELSQETPNDLLAR------ELWCQA-GNAAEWRQSVRRFVRCMSVMSMIGYVIGLGD 2104
            |..|:|..|:       ||.|      |.:.:. .:...|..|...:.|..:||||:||::||||
  Rat  2410 SEKLKVFQEI-------LLPRHPPVFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGD 2467

  Fly  2105 RHLDNVLINLGSGDIVHIDYNVCFEKGRTLRIPEKVPFRLTQNLVQAMGITGIEGPFRLGCEYVL 2169
            ||.:|:|.:..:|:.||:|:|..|.||.|..:||.||||||.|:|..||..|.||.||..||..|
  Rat  2468 RHGENILFDSFTGECVHVDFNCLFNKGETFEVPEIVPFRLTHNMVNGMGPMGTEGLFRRACEVTL 2532

  Fly  2170 KVMRKERETLLTLLEAFVYDPLVDWT 2195
            ::||.:||.|:::|:.|::||||:|:
  Rat  2533 RLMRDQREPLMSVLKTFLHDPLVEWS 2558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nonC	NP_001284967.1	SMG1	571..1140	CDD:292413	150/775 (19%)
		Rapamycin_bind	1738..1845	CDD:285924	19/109 (17%)
		PIKKc_SMG1	1894..2196	CDD:270714	107/315 (34%)
		FATC	3189..3217	CDD:280430
Atr	XP_003750609.1	UME	1120..1226	CDD:214825	27/125 (22%)
		FAT	1766..2087	CDD:280429	80/460 (17%)
		TEL1	<2118..2636	CDD:227365	147/517 (28%)
		PIKKc_ATR	2285..2559	CDD:270625	107/315 (34%)
		FATC	2605..2636	CDD:280430
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900