DRSC/TRiP Functional Genomics Resources

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Protein Alignment nonC and pik3c2a

DIOPT Version :9

Sequence 1:NP_001284967.1 Gene:nonC / 31625 FlyBaseID:FBgn0263968 Length:3218 Species:Drosophila melanogaster
Sequence 2:XP_005159362.2 Gene:pik3c2a / 571356 ZFINID:ZDB-GENE-030328-39 Length:1691 Species:Danio rerio


Alignment Length:1841 Identity:341/1841 - (18%)
Similarity:573/1841 - (31%) Gaps:630/1841 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   868 RTTVGKPQETFLGFEAIIMRHARLLSGCAKEIERSA----LDDLSLEELLSMQSNLSLLLGFLDA 928
            :|:..:|::..:.|             |..|.::..    .:|:.||.|..            :.
Zfish    67 QTSTSRPEKDLIVF-------------CESETQKKEQKDNFEDIDLENLTK------------EE 106

  Fly   929 LEKLIYNAAEGSAFALRPPEK---QVAAFF---RLNNPTCQSWFNRIRIGVVIIAMHVQQPELVI 987
            ||||:.:.:.|:....||...   .::|.:   ...||:...|        .....|.|.|    
Zfish   107 LEKLLLDDSFGANKMTRPSSLLGCNLSASYPGGHAFNPSSFHW--------TPTPTHAQTP---- 159

  Fly   988 RYAQQILVNSKTQDPT------YSQAI--------------VYMAWSLVSCQEADSLRGLRLWAR 1032
                 |..::....|.      :|.|:              :....:||..|.|.:....:|:.:
Zfish   160 -----IFPSAPFAKPPCSFQNGFSPAMSPFIPPTPFLSFTPIQPPAALVYSQPAVTPEMAKLFDK 219

  Fly  1033 GKSCKSYKWLKYAADQAAGKRESALAGYRTILAEKELQSELEPHTRQFVVSQMMQCLQDLGQWSQ 1097
            ..|...|                 |...|:...|.|              |..::.|:.|.|.|:
Zfish   220 IASTSEY-----------------LKNGRSSSMETE--------------SASVKSLEPLPQPSE 253

  Fly  1098 LVELKQQQMTRPEDRELNPFLQRSNVEVNALERLLAKS-----EESCSSMDALGGVFQQLSLWPS 1157
                 ...::|.|..:|:|..:|..|||   |...|.|     |||..:.|....|.|       
Zfish   254 -----PPNISRFEWLDLDPLNKRKEVEV---EETPAVSSCPFIEESGKAKDPWDAVLQ------- 303

  Fly  1158 NWDESVSSSGLSERASFSSIHMRQRTEDIVLHKLLEDRCVPDQAKNLLDTQWRDSLLNPSFDQRS 1222
              ||..:....|.:|                    |::|                          
Zfish   304 --DEHETVDNGSPKA--------------------EEKC-------------------------- 320

  Fly  1223 CKELTLLRHIVQGVSGGQELSLLPVSSGRCQNRSKFISSAILMRCLAWTQLLRQHCAPGSWETLC 1287
              :.|..|....|.:..:..||...|:...|:..|.::.                   ||...|.
Zfish   321 --KATQPRRASTGAAVTKSQSLSISSNSTNQSTGKQVNK-------------------GSTNVLS 364

  Fly  1288 LDAAAAAREEGNLQLAETLLTQFFGQPIGEIAALFSLEQGVQTDNPEML-------------RGY 1339
            ..:|...:|..||::..      |.:.|.::.:.|..:.  .:.||..:             .|.
Zfish   365 KYSALQEKEAQNLEVVA------FCEDISKLRSKFPHDD--LSTNPGYVLSPVITQRDAGGDNGG 421

  Fly  1340 SELVKCLHLQQQQSQTHSGDLSSSID--VCAALC-----LNIQKSN--------------NQPAA 1383
            |..|.......||..|.:.|::|.:|  :..|||     ||....|              |:.:.
Zfish   422 SVKVSIEISDSQQPVTFTCDVTSPVDLLIMQALCWVHDDLNQVDINSYVLKVCGQEEVLQNKHSL 486

  Fly  1384 GA-DLLLNLADWIAVRTCNGLTTNQSPVLIQLL---DQLPECPLTC-DSSQPLAIPQAERMVARL 1443
            |: :.:.|...|            :|.:.:|||   ....:...|. |...|:.:.:...:|.|.
Zfish   487 GSHEYVQNCRKW------------ESEIKLQLLFLSTMRRDLARTAEDDISPIDLEKYLGLVERP 539

  Fly  1444 VHSCLQQR--PNYAEALIAYGNWC-------YRWGKKVADS----CCVLTQADATAISQA----- 1490
            ....:.:.  ..|.|......|.|       |:....|..|    ||.|.:.:..||:.|     
Zfish   540 FKEAVTREGLAEYLEGFHKQVNLCLQNENNQYKTVDNVVQSVKNLCCALDEVETPAITDAVKRLK 604

  Fly  1491 --LDIPQPLESEKLDELLQALST---------EQPPANCVEVCPDAA------------------ 1526
              :::|:....|...| |||.:|         ..|....:.|..||.                  
Zfish   605 RSVNLPRTRSPEHYAE-LQAGATSSGGSANGYSSPVEESLAVLTDAVYELAKLYLQSFCPISPGF 668

  Fly  1527 -------RARDDEAAKNRLRRLTFLADKTPEALDAILQIWRRAIANTYDYYKDAARSYFQYLSFK 1584
                   ..||.:.|......|.|    |..|:..|...|   :::...||...|.::.....||
Zfish   669 MIEEHKEDERDSKEASGTTEHLQF----TLFAVHGIPATW---VSSFEKYYLMCALTHNNRNLFK 726

  Fly  1585 SGSGPEKPEGEGVVSQRERLHVDDSNLVT--TTLRLLRLIVKHASGLQEVLEQGLHTTPIAPWKV 1647
                |.:.:..|.. :....|:....|:.  .::.||.|....:..|..||.|..:.:|.:..:.
Zfish   727 ----PVQSKKVGTY-KSFFYHIKWDELINFPISVSLLPLEAMLSLSLYGVLSQNANNSPDSNKQR 786

  Fly  1648 IIPQLFSRLNHHEPYVRKSVCDLLCRLAK-----SRPQLVIFPAVVGANRE-------QQDATAP 1700
            ..|:|..:::......|:    :|.|.:|     :.|| .:.|...|..|.       |.|..:|
Zfish   787 KGPELLGKVSMPLFDFRR----VLSRGSKLLSLWTSPQ-ALQPGAAGKGRNPTEKIILQVDFPSP 846

  Fly  1701 PATAR--PTTEDACCYGYLLGELSKQAPEAVQHVKLMVKELRRVC--------------LLWD-- 1747
            .....  ...|:.|.....|..|.:...          .|:.::|              ||||  
Zfish   847 AVDVLYVGPQENGCPNPQSLDPLDQDDR----------SEIEKLCARASTFGLSRADRQLLWDQR 901

  Fly  1748 ------EY-------------W-----IHSLAHIYNTY--VSRVSALATDFRPDD---------H 1777
                  ||             |     ||:|.|.:...  ||.:..|.:.|...:         .
Zfish   902 YYCREYEYSLPKILASAPSWDWGSMGEIHALLHHWPALSPVSALELLESKFADTEVRKVAVSWIQ 966

  Fly  1778 EGKNNRFNVWRPQLLADLE-------ALVA-VTSRP--------------PETTYERSFRKRFD- 1819
            ...::....:.|||:..::       |||. :.||.              .:...:.:|.:|:: 
Zfish   967 SSSDDELADYLPQLVQAVKFECHLKNALVKFLLSRALGNVNIAHYLYWLLRDAVQDPAFGQRYER 1031

  Fly  1820 -APIRLTVDALRHRRYPEAWDKLKQLYHILQSNMIRGSGSTLKMQSISPVLCGIGRMRISMPGLD 1883
             ..:.|.:.....|...|...:|.||...|...:.:.|.||.::    .:|.|:.|::.......
Zfish  1032 ILCVLLCLCGTGLRAELEKQTRLVQLLGALAEKVRQASSSTRQV----VLLEGLERVQSFFQKNS 1092

  Fly  1884 AHGPDGDQVYIESVESSVC-VLPTKTKPKKVAFYGSN--GQRYTFLFKGMEDLHLDERIMQFLSI 1945
            ...|....:..:.:...|| ...:...|.|:|...::  |.....:||..|||..|...:|.:.|
Zfish  1093 CRLPISPSLVAKELNIKVCSFFNSNAVPLKIALVNADPLGDEINVMFKVGEDLRQDMLALQMIRI 1157

  Fly  1946 SNAIMACRSDAPGNGC-YRAHHYSVIPLGPQSGLISWVDGVTPVFALYKKWQQRRSQVAGNAGAG 2009
            .:.|..      ..|. .|..::..|..|...|::..|    |.....:|.|             
Zfish  1158 MDRIWL------QEGLDLRIVNFKCISTGKDKGMVELV----PSSETLRKIQ------------- 1199

  Fly  2010 AVANVPRRFTDLFYNKLSPLLAKHNMQVSDPRRQWPISVLLQVLDELSQETPNDLLARELWCQAG 2074
                |....|..|.:|              |..:|           |.:..|.:           
Zfish  1200 ----VEYGVTGSFKDK--------------PLAEW-----------LRKYNPAE----------- 1224

  Fly  2075 NAAEWRQSVRRFVRCMSVMSMIGYVIGLGDRHLDNVLINLGSGDIVHIDYNVCFEKGRTLRI--- 2136
              .|:.::...|:...:...:..|::|:.|||.||:::. .:|.:.|||:....  |....|   
Zfish  1225 --DEYEKASENFIYTCAGCCVATYILGICDRHNDNIMLR-STGHMFHIDFGKFL--GHAQMIGSF 1284

  Fly  2137 -PEKVPFRLTQNLVQAMGITGIEGP---FRLG---CEYVLKVMRKERETLLTLLE---------- 2184
             .::.||.||.::  |..|.|.|.|   |:|.   |.....::||.....|.||.          
Zfish  1285 KRDRAPFVLTSDM--AYVINGGERPTSRFQLFVDLCSQAYNLIRKHSNLFLNLLSLMTQSGLPEL 1347

  Fly  2185 ------AFVYDPLVDWTTNDDAQALRRSLNAKLQESADGGGAGGL-----GVGDLKYHKKDKNKG 2238
                  .:|||.|...||  ||:|  .....:|.||:.|..|...     .:..|::      .|
Zfish  1348 TGVQDLKYVYDALQPQTT--DAEA--TIFFTRLIESSLGSVATKFNFFIHNLAQLRF------SG 1402

  Fly  2239 KPLDSDVKRQPFLSKLGMLQKYWSTNKTELMPQLEEMEQEVGNLQAAQAKQVVAEEELVKLNQRS 2303
            .|.:.    :|.||               ..|:...|:|: |.::.|   .|.:.::....::..
Zfish  1403 LPSND----EPILS---------------FAPRTYTMKQD-GKIRDA---SVFSYQKRYNPDKHY 1444

  Fly  2304 ALIAEIKSLGTAIESHSFNTASLRNAVRRGHSEALALLSTERLPDFGRVQCILRSYGQCLQLYHL 2368
            ..:..|                    :|.|.||          |.|     :.|::.:..:|::.
Zfish  1445 TYVIRI--------------------LREGQSE----------PQF-----VFRTFDEFQELHNK 1474

  Fly  2369 LDLQGQLVKLQMESNSENAREFSALTEALQLSGLDSMRSQLNELLGRMDM--VAQKSSKHLQEYA 2431
            |.:..||.|                     |.|..|     ..:|||..:  ||.|....|..|.
Zfish  1475 LTILFQLWK---------------------LPGFPS-----KMVLGRTHIKDVASKRKVELNSYV 1513

  Fly  2432 -GVMNFYPEQSHRQNLFVRFH 2451
             .:|....|.:....::..||
Zfish  1514 HNLMRSSTEVAQCDLIYTFFH 1534

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nonCNP_001284967.1 SMG1 571..1140 CDD:292413 57/306 (19%)
Rapamycin_bind 1738..1845 CDD:285924 32/181 (18%)
PIKKc_SMG1 1894..2196 CDD:270714 68/331 (21%)
FATC 3189..3217 CDD:280430
pik3c2aXP_005159362.2 Amelogenin <137..207 CDD:330537 12/86 (14%)
PI3K_rbd 420..507 CDD:307097 21/98 (21%)
C2A_PI3K_class_II 681..852 CDD:175979 38/187 (20%)
PI3Ka 872..1038 CDD:320871 27/175 (15%)
PKc_like 1045..1397 CDD:328722 91/429 (21%)
PX_PI3K_C2_alpha 1428..1536 CDD:132822 30/171 (18%)
C2B_PI3K_class_II 1565..1686 CDD:176027
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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