DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment nonC and Mtor

DIOPT Version :9

Sequence 1:NP_001284967.1 Gene:nonC / 31625 FlyBaseID:FBgn0263968 Length:3218 Species:Drosophila melanogaster
Sequence 2:NP_063971.1 Gene:Mtor / 56718 RGDID:68371 Length:2549 Species:Rattus norvegicus


Alignment Length:2396 Identity:489/2396 - (20%)
Similarity:855/2396 - (35%) Gaps:733/2396 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   220 KSSKRMQKYMIMALRATLSCDTKCELHMYADKIMLLL------KDFLENAE-----SADIFIVVS 273
            |..:|...:..:.|   ||...:.|..:|..:::.::      |||....:     .|.:|..:|
  Rat   426 KEKERTAAFQALGL---LSVAVRSEFKVYLPRVLDIIRAALPPKDFAHKRQKTVQVDATVFTCIS 487

  Fly   274 NTLVQFAASYAETFECHFTDVVDIVIGWQLEAGQPT---DLKTHCAQVLEQLTPFFSKQID---- 331
                ..|.:.....:....::::.::...|......   ||.....|:.:.:.....|.:.    
  Rat   488 ----MLARAMGPGIQQDIKELLEPMLAVGLSPALTAVLYDLSRQIPQLKKDIQDGLLKMLSLVLM 548

  Fly   332 --------FSYGLLDQFVE-DITTLEEGEPANTAERVGAFVGAFNTLLKCLARMQIFVGMPTCEC 387
                    ...||..|... .:|||.|...          |.:....|:.|...: |.|....: 
  Rat   549 HKPLRHPGMPKGLAHQLASPGLTTLPEASD----------VASITLALRTLGSFE-FEGHSLTQ- 601

  Fly   388 IVKMAVDHLIK-----------------IMPTLHL--------NTEALVNINELICICLLNNFTG 427
            .|:...||.:.                 :.|::||        :..|:..:.:::...|:...|.
  Rat   602 FVRHCADHFLNSEHKEIRMEAARTCSRLLTPSIHLISGHAHVVSQTAVQVVADVLSKLLVVGITD 666

  Fly   428 LDPILLEQVLLDQVKRM-ISLTELQRQSVLY------------LLLCTVRRLRARLTPSLVHFIF 479
            .||.:...||....:|. ..|.:.:....|:            |.:|||.|| :.:.|:.|    
  Rat   667 PDPDIRYCVLASLDERFDAHLAQAENLQALFVALNDQVFEIRELAICTVGRL-SSMNPAFV---- 726

  Fly   480 QSNPYMTKVRLRSPGETSYKLLLRTCQETL-----LIRNVPLLQQAY-----KYLV--------D 526
              .|::.|:.::...|..:..:.|..:::.     |:.|.|.|.:.|     |.|:        |
  Rat   727 --MPFLRKMLIQILTELEHSGIGRIKEQSARMLGHLVSNAPRLIRPYMEPILKALILKLKDPDPD 789

  Fly   527 DIDACLEKLLIT----------APRSKARKASVLLVFHLSALAALAKQ-------------TSSI 568
            .....:..:|.|          ..|....:..|:::..|...:.|||:             |..:
  Rat   790 PNPGVINNVLATIGELAQVSGLEMRKWVDELFVIIMDMLQDSSLLAKRQVALWTLGQLVASTGYV 854

  Fly   569 IGMYACKPSILELLLTNCRAHELKFWSKYPAAQQAI--FGLLVV--------------------- 610
            :..|...|::||:||     :.||........::||  .|||..                     
  Rat   855 VEPYRKYPTLLEVLL-----NFLKTEQNQGTRREAIRVLGLLGALDPYKHKVNIGMIDQSRDASA 914

  Fly   611 -------HCQANHNFRTNSSLL-----------------------RDQELSAENT---------- 635
                   ..|.:.::.|:..|:                       |||.||..:|          
  Rat   915 VSLSESKSSQDSSDYSTSEMLVNMGNLPLDEFYPAVSMVALMRIFRDQSLSHHHTMVVQAITFIF 979

  Fly   636 --------------SPTANSFASILR--------FLDSVLGQAHQLAPQNLRVLLQWIQMLLRE- 677
                          .||   |.:::|        ||...||........::|..:..|..|:|| 
  Rat   980 KSLGLKCVQFLPQVMPT---FLNVIRVCDGAIREFLFQQLGMLVSFVKSHIRPYMDEIVTLMREF 1041

  Fly   678 ------CREKIDLLMEQ--------------------------ENFRGICRNIAATASKLVPLES 710
                  .:..|.||:||                          :|.:|          ::|.::.
  Rat  1042 WVMNTSIQSTIILLIEQIVVALGGEFKLYLPQLIPHMLRVFMHDNSQG----------RIVSIKL 1096

  Fly   711 AACIQ----TVLDY------GLERLEKYPKLLILYRDTALQQLQMLS-----TNYHA----PYFQ 756
            .|.||    .:.||      .:.:|...|::.:..|..||:.:..|:     |:|.:    |..:
  Rat  1097 LAAIQLFGANLDDYLHLLLPPIVKLFDAPEVPLPSRKAALETVDRLTESLDFTDYASRIIHPIVR 1161

  Fly   757 IYAQLP-LHLTLTGGESSMPGMASRRVSVWQQRISQYSAVRDNVFRDFFD----RVQK------P 810
            ...|.| |..|.....||:.....::..::...:::. .||..:....:|    |:.|      .
  Rat  1162 TLDQSPELRSTAMDTLSSLVFQLGKKYQIFIPMVNKV-LVRHRINHQRYDVLICRIVKGYTLADE 1225

  Fly   811 EQDSLIHCLRELFVRSCQ----------VAPQDE---RQMNLSQCTKRCQRLA----IAWLQ--- 855
            |:|.||:..|.|  ||.|          ..|..:   ..:||.:.....:|::    :.||:   
  Rat  1226 EEDPLIYQHRML--RSSQGDALASGPVETGPMKKLHVSTINLQKAWGAARRVSKDDWLEWLRRLS 1288

  Fly   856 FEAARYCVDQRLRT-----TVGKPQETFLGFEAIIMRHARLLSGCAKEIERSALDDL--SLEELL 913
            .|..:......||:     ....|....| |.|..:       .|..|:.....|:|  |:|..|
  Rat  1289 LELLKDSSSPSLRSCWALAQAYNPMARDL-FNAAFV-------SCWSELNEDQQDELIRSIELAL 1345

  Fly   914 SMQSNLSLLLGFLDALEKLIYNAAEGSAFALRPPEKQVAAFFRLNNPTCQSWFNRIRIGVVII-- 976
            :.|.        :..:.:.:.|.||....:.:.|..     .|.:|            |:|::  
  Rat  1346 TSQD--------IAEVTQTLLNLAEFMEHSDKGPLP-----LRDDN------------GIVLLGE 1385

  Fly   977 ----------AMHVQQPELVIRYAQQIL-----VNSKTQDPTYSQAIVYMAWSLVSCQEADSLRG 1026
                      |:|.::.|........||     :|:|.|.|..:..::..|     .:....|..
  Rat  1386 RAAKCRAYAKALHYKELEFQKGPTPAILESLISINNKLQQPEAASGVLEYA-----MKHFGELEI 1445

  Fly  1027 LRLWARGKSCKSYKWLKYAADQAAGKRESALAGYRTILAEKELQSEL-EPHTRQFVVSQMMQCLQ 1090
            ...|..    |.::|            |.||..|     :|::.:.. :|.    ::...|:||:
  Rat  1446 QATWYE----KLHEW------------EDALVAY-----DKKMDTNKDDPE----LMLGRMRCLE 1485

  Fly  1091 DLGQWSQLVELKQQQMTRPEDRELNPFLQRSNVEVNALERLLAKSEESCSSMDALGGVFQQLSLW 1155
            .||:|.||    .||                     ..|:....::|:.:.|..:...    :.|
  Rat  1486 ALGEWGQL----HQQ---------------------CCEKWTLVNDETQAKMARMAAA----AAW 1521

  Fly  1156 P-SNWDESVSSSGLSERASFSSIHMRQRTEDIVLHK---LLEDRCVPDQAKNLLDTQWRDSLLNP 1216
            . ..||.....:.:..|.:......|   ..:.||:   .|..:|: |:|::|||.: ..::...
  Rat  1522 GLGQWDSMEEYTCMIPRDTHDGAFYR---AVLALHQDLFSLAQQCI-DKARDLLDAE-LTAMAGE 1581

  Fly  1217 SFDQR-----SCKELTLLRHIVQGVSGGQELSLLPVSSGRCQNRSKFISSAILMRCLAWTQLLRQ 1276
            |:.:.     ||..|:.|..::|       ..|:|      :.|.       ::|.:.|.:|  |
  Rat  1582 SYSRAYGAMVSCHMLSELEEVIQ-------YKLVP------ERRE-------IIRQIWWERL--Q 1624

  Fly  1277 HC--APGSWETLC----------------LDAAAAAREEGNLQLAETLLTQFFGQPIGEIAALFS 1323
            .|  ....|:.:.                |..|:...:.|.|.||...|....|     :.....
  Rat  1625 GCQRIVEDWQKILMVRSLVVSPHEDMRTWLKYASLCGKSGRLALAHKTLVLLLG-----VDPSRQ 1684

  Fly  1324 LEQGVQTDNPEMLRGY--------SELVKCLHLQ------QQQS--------QTHSGDLSSSIDV 1366
            |:..:.|.:|::...|        .::....|:|      |||:        |.|..:|...:..
  Rat  1685 LDHPLPTVHPQVTYAYMKNMWKSARKIDAFQHMQHFVQTMQQQAQHAIATEDQQHKQELHKLMAR 1749

  Fly  1367 CAALCLNIQKSNNQPAAGADLLLNLADWIAVRTCNGLTTNQSPVLIQLLDQLPECPLTCDSSQPL 1431
            |                    .|.|.:|  .....|:..:..|.::|...               
  Rat  1750 C--------------------FLKLGEW--QLNLQGINESTIPKVLQYYS--------------- 1777

  Fly  1432 AIPQAERMVARLVHSCLQQRPNYAEALIAYGNWCYRWGKKVADSCCVLTQADATAISQALDIPQP 1496
            |..:.:|...:..|:....  |: ||::.|.:.                       :||.|..:.
  Rat  1778 AATEHDRSWYKAWHAWAVM--NF-EAVLHYKHQ-----------------------NQARDEKKK 1816

  Fly  1497 LESEKLDELLQALSTEQPPANCVEVCPDAARARDDEAAKNRLRRL-TFLADKTPEALDAILQIWR 1560
            |.......:..|.:|....|:............:.||..|..... :.|..|..|.|...|.:  
  Rat  1817 LRHASGANITNATTTATTAASAAAATSTEGSNSESEAESNESSPTPSPLQKKVTEDLSKTLLL-- 1879

  Fly  1561 RAIANTYDYYKDAARSYFQYLSFKSGSGPEKPEGEGVVSQRERLHVDDSNLVTTTLRLLRLIVK- 1624
                    |...|.:.:|:.:|...|                       |.:..|||:|.|... 
  Rat  1880 --------YTVPAVQGFFRSISLSRG-----------------------NNLQDTLRVLTLWFDY 1913

  Fly  1625 -HASGLQEVLEQGLHTTPIAPWKVIIPQLFSRLNHHEPYVRKSVCDLLCRLAKSRPQLVIFPAVV 1688
             |...:.|.|.:|:....|..|..:||||.:|::...|.|.:.:..||..:.:..||.:|:|..|
  Rat  1914 GHWPDVNEALVEGVKAIQIDTWLQVIPQLIARIDTPRPLVGRLIHQLLTDIGRYHPQALIYPLTV 1978

  Fly  1689 GANREQQDATAPPATARPTTEDACCYGYLLGELSKQAPEAVQHVKLMVKELRRVCLLWDEYWIHS 1753
                    |:....|||....:.     :|..:.:.:...||...::.:||.||.:||.|.|...
  Rat  1979 --------ASKSTTTARHNAANK-----ILKNMCEHSNTLVQQAMMVSEELIRVAILWHEMWHEG 2030

  Fly  1754 LAHIYNTYVSRVSALATDFRPDDHEGKNN---RFNVWRPQLLADLEALVAVTSRPPETTYERSFR 1815
            |......|.                |:.|   .|.|        ||.|.|:..|.|:|..|.||.
  Rat  2031 LEEASRLYF----------------GERNVKGMFEV--------LEPLHAMMERGPQTLKETSFN 2071

  Fly  1816 KRFDAPIRLTVDALRH-------RRYPEAWDKLKQLYHILQ--SNMIRGSGSTLKMQSISPVLCG 1871
            :.:...:....:..|.       :...:|||   ..||:.:  |..: ...::|::|.:||.|..
  Rat  2072 QAYGRDLMEAQEWCRKYMKSGNVKDLTQAWD---LYYHVFRRISKQL-PQLTSLELQYVSPKLLM 2132

  Fly  1872 IGRMRISMPGLDAHGPDGDQVYIESVESSVCVLPTKTKPKKVAFYGSNGQRYTFLFKGMEDLHLD 1936
            ...:.:::||  .:.|:...:.|:|:..|:.|:.:|.:|:|:...||||..:.||.||.|||..|
  Rat  2133 CRDLELAVPG--TYDPNQPIIRIQSIAPSLQVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQD 2195

  Fly  1937 ERIMQFLSISNAIMA-----CRSDAPGNGCYRAHHYSVIPLGPQSGLISWVDGVTPVFALYKKWQ 1996
            ||:||...:.|.::|     .|.:      .....|:||||...||||.||.....:.||.:.::
  Rat  2196 ERVMQLFGLVNTLLANDPTSLRKN------LSIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYR 2254

  Fly  1997 QRRSQVAGNAGAGAVANVPRRF-----TDLFYNKLSPLLAKHNMQVSDPRRQWPISVLLQVLDEL 2056
            :::.         .:.|:..|.     .|  |:.|: |:.|                 ::|.:..
  Rat  2255 EKKK---------ILLNIEHRIMLRMAPD--YDHLT-LMQK-----------------VEVFEHA 2290

  Fly  2057 SQETPNDLLARELWCQAGNAAEWRQSVRRFVRCMSVMSMIGYVIGLGDRHLDNVLINLGSGDIVH 2121
            ...|..|.||:.||.::.::..|......:.|.::||||:||::||||||..|::::..||.|:|
  Rat  2291 VNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILH 2355

  Fly  2122 IDYNVCFEKGRTL-RIPEKVPFRLTQNLVQAMGITGIEGPFRLGCEYVLKVMRKERETLLTLLEA 2185
            ||:..|||...|. :.|||:|||||:.|..||.:||::|.:|..|..|::|:|:.:::::.:|||
  Rat  2356 IDFGDCFEVAMTREKFPEKIPFRLTRMLTNAMEVTGLDGNYRTTCHTVMEVLREHKDSVMAVLEA 2420

  Fly  2186 FVYDPLVDWTTND-DAQALRRSLNAKLQESADGGGAG-------GLGVGDLKYHKK 2233
            ||||||::|...| :|:..:||     :...|...||       |:.:|: ..|||
  Rat  2421 FVYDPLLNWRLMDTNAKGNKRS-----RTRTDSYSAGQSVEILDGVELGE-PAHKK 2470

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nonCNP_001284967.1 SMG1 571..1140 CDD:292413 138/761 (18%)
Rapamycin_bind 1738..1845 CDD:285924 28/116 (24%)
PIKKc_SMG1 1894..2196 CDD:270714 107/312 (34%)
FATC 3189..3217 CDD:280430
MtorNP_063971.1 HEAT repeat 993..1021 CDD:293787 8/30 (27%)
HEAT 25 1029..1068 9/38 (24%)
HEAT repeat 1033..1062 CDD:293787 9/28 (32%)
HEAT 26 1069..1105 6/45 (13%)
HEAT repeat 1073..1099 CDD:293787 3/35 (9%)
HEAT 27 1106..1144 8/37 (22%)
HEAT repeat 1111..1142 CDD:293787 5/30 (17%)
HEAT 28 1145..1188 9/42 (21%)
HEAT repeat 1154..1180 CDD:293787 6/25 (24%)
HEAT 29 1189..1225 5/36 (14%)
HEAT 30 1226..1273 12/48 (25%)
HEAT 31 1274..1311 6/36 (17%)
HEAT 32 1312..1345 10/40 (25%)
TPR 1 1346..1382 8/60 (13%)
TPR 2 1383..1408 3/24 (13%)
TPR 3 1409..1442 7/37 (19%)
TPR 4 1443..1473 9/50 (18%)
TPR 5 1474..1507 12/61 (20%)
TPR 6 1508..1541 5/36 (14%)
TPR 7 1542..1574 10/35 (29%)
TPR 8 1575..1614 9/58 (16%)
TPR 9 1615..1649 6/35 (17%)
TPR 10 1650..1693 10/47 (21%)
TPR 11 1694..1731 7/36 (19%)
TPR 12 1732..1786 12/90 (13%)
TPR 13 1787..1846 12/84 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1812..1867 9/54 (17%)
TPR 14 1898..1930 10/31 (32%)
TPR 15 1931..1970 11/38 (29%)
TPR 16 1971..2005 8/46 (17%)
Sufficient for interaction with the FKBP1A/rapamycin complex. /evidence=ECO:0000250 2012..2144 38/161 (24%)
Rapamycin_bind 2015..2112 CDD:285924 30/123 (24%)
PIKKc_TOR 2153..2431 CDD:270713 107/312 (34%)
Interaction with MLST8. /evidence=ECO:0000250 2258..2296 9/66 (14%)
FATC 2518..2549 CDD:280430
Interaction with NBN. /evidence=ECO:0000250 1..651 38/243 (16%)
TEL1 363..2549 CDD:227365 489/2396 (20%)
HEAT 16 637..683 7/45 (16%)
HEAT repeat 655..681 CDD:293787 6/25 (24%)
HEAT 17 686..724 8/38 (21%)
HEAT repeat 691..721 CDD:293787 7/30 (23%)
HEAT 18 727..766 6/38 (16%)
HEAT repeat 729..759 CDD:293787 3/29 (10%)
HEAT 19 769..811 6/41 (15%)
HEAT repeat 772..805 CDD:293787 5/32 (16%)
HEAT 20 814..853 7/38 (18%)
HEAT repeat 817..847 CDD:293787 5/29 (17%)
DUF3385 854..1024 CDD:288698 30/177 (17%)
HEAT 21 857..893 13/40 (33%)
HEAT 22 894..942 3/47 (6%)
HEAT 23 943..988 6/44 (14%)
HEAT repeat 955..981 CDD:293787 6/25 (24%)
HEAT 24 989..1027 8/40 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D26975at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11139
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
44.010

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