DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nonC and pik3ca

DIOPT Version :9

Sequence 1:	NP_001284967.1	Gene:	nonC / 31625	FlyBaseID:	FBgn0263968	Length:	3218	Species:	Drosophila melanogaster
Sequence 2:	XP_009304451.1	Gene:	pik3ca / 561737	ZFINID:	ZDB-GENE-130409-1	Length:	1069	Species:	Danio rerio

Alignment Length:	1220	Identity:	215/1220 - (17%)
Similarity:	371/1220 - (30%)	Gaps:	426/1220 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  1110 EDRELNPFLQRSNVEVNALERLLAKSEESCSSMDALGGVFQQLSLWPSNWDES------------ 1162
            :|.|:..|  |.|:        |...::|....||.|...:.|.::|.|.:.|
Zfish   132 KDPEVQDF--RRNI--------LNVCKDSVELRDASGAHSRALYVYPPNVESSPELPKHIYGKLD 186

  Fly  1163 -----------VSSSGLSERASFSSIH-----------MRQRTEDIVLHKLLEDRCVPD-QAKNL 1204
                       ||.:...::.:....|           :|::|..::|.......||.: |.|.:
Zfish   187 KGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSAEQLKMCVQEYQGKYI 251

  Fly  1205 LDTQWRDSLLNPSFD------QRSCKELTLLRHIVQGVSGGQELSLLPVSSGRCQNRSKFISSAI 1263
            |.....|..|...:.      .|||..|..|.:::. :|.....|.||:.:....:.|:.||:|.
Zfish   252 LKVCGCDEYLLEKYPISQYKYVRSCIMLGRLPNLML-MSKDSLYSQLPMDNFTMPSYSRRISTAT 315

  Fly  1264 -LMRCLAWTQLLRQHCAPGSW---ETLCLDAAAAAREEGNLQLAETLLTQFFGQPIGEIAALFSL 1324
             .|...|.|:.|        |   .||.:....|.....|:            :.|.:|.....:
Zfish   316 PYMNGEASTKSL--------WTINSTLRIRVLCATYVNVNI------------RDIDKIYVRTGI 360

  Fly  1325 EQGVQ--TDNPEMLRGYSELVKCLHLQQQQSQTHSGDLSSSIDVCAALCLNI--------QKSNN 1379
            ..|.:  .||....|     |.|.:.:..:..|:...: ..|...|.|||:|        .|..:
Zfish   361 YHGGEQLCDNVNTQR-----VPCSNPRWNEWLTYDMYI-PDIPRAARLCLSICSVKGRKGAKEEH 419

  Fly  1380 QPAAGADLLLNLADWIAVRTCNGLTTNQSPVLIQLLDQLPECPLTCDSSQPLAI----PQAERMV 1440
            .|.|..:  :||.|:........:..|..||...|.|.|          .|:.:    |..|.
Zfish   420 CPLAWGN--VNLFDYTHTLVSGKMALNLWPVPHGLEDLL----------NPIGVTGSNPNKET-- 470

  Fly  1441 ARLVHSCLQQRPNYAEALIAY---------GNWCYRWGKKVADSCCVLTQADATAISQAL---DI 1493
                 .||:...:|..:.:.:         .||..  .:::..:.|...|:...|...|:   ||
Zfish   471 -----PCLELEFDYFSSPVKFPDMATIEDHANWII--SREMGYNYCQSGQSSRVARDHAMTEADI 528

  Fly  1494 PQPLESEKLDELLQALSTEQPPANCVEVCPDAARARDDEAAKNRLRRLTFLADKTPEALDAILQI 1558
            .|          |:.|....|.:...            |..|:.|.|........||.|..||..
Zfish   529 EQ----------LRQLGNRDPLSEIT------------EQEKDFLWRHRQYCVNIPEILPKILLA 571

  Fly  1559 --W--RRAIANTYDYYKD-AARSYFQYLSFKSGSGPEKPEGEGVVSQRERLHVDD--SNLVTTTL 1616
              |  |..:|..|...|| .|....|.:.....:.|:....:..|...|:...||  |..:...:
Zfish   572 VKWNSRDEVAQMYCLLKDWPAIKPEQAMELLDCNYPDPMIRDFAVRCLEKYLTDDKLSQYLIQLV 636

  Fly  1617 R-----------LLRLIVKHASGLQEV-------LEQGLHTTPIAPWKVIIPQLFSRLNHHEPYV 1663
            :           |:|.::|.|...|.:       |:..:|...::       |.|..|  .|.|.
Zfish   637 QVLKYEQYLDNPLVRFLLKKALTNQRIGHFFFWHLKSEMHNKTVS-------QRFGLL--LESYC 692

  Fly  1664 RKSVCDL----LCRLAKSRPQLVIFPAVVGANREQQDATAPPATARPTTEDACCYGYLLGELSKQ 1724
            |  .|.:    |.|..::..:|:....::  .:|::|.|
Zfish   693 R--ACGMYLKHLSRQVEAMEKLINLTDIL--KQEKKDET-------------------------- 727

  Fly  1725 APEAVQHVKLMVKELRRVCLLWDEYWIHSLAHIYNTYVSRVSALATDFRPDDHEGKNNRFNVWRP 1789
              :.|| :|.:|:::||                 ..|:..:....:...| .|:..|.|....|
Zfish   728 --QKVQ-MKFLVEQMRR-----------------PDYMDALQNFTSPLNP-AHQLGNLRLEDCR- 770

  Fly  1790 QLLADLEALVAVTSRPPETTYERSFRKRFDAPIRLTVDALRHRRYPEAWDKLKQLYHILQSNMIR 1854
                    :::...||....:|.                      |:...:|     :.|:|.|
Zfish   771 --------IMSSAKRPLWLNWEN----------------------PDIMSEL-----LFQNNEI- 799

  Fly  1855 GSGSTLKMQSISPVLCGIGRMRISMPGLDAHGPDGDQVYIESVESSVCVLPTKTKPKKVAFYGSN 1919

Zfish   800 ----------------------------------------------------------------- 799

  Fly  1920 GQRYTFLFKGMEDLHLDERIMQFLSISNAIMACRSDAPGNGC-YRAHHYSVIPLGPQSGLISWVD 1983
                  :||..:||..|...:|.:.|...|.      ...|. .|...|..:.:|...|||..|.
Zfish   800 ------IFKNGDDLRQDMLTLQIIRIMENIW------QNQGLDLRMLPYGCLSIGDCVGLIEVVR 852

  Fly  1984 GVTPVFALYKKWQQRRSQVAGNAGAGAVANVPRRFTDLFYNKLSPLLAKHNMQVSDPRRQWPISV 2048
            ....:..:..|        .|..||            |.:|             |....||
Zfish   853 SSHTIMQIQCK--------GGLKGA------------LQFN-------------STTLHQW---- 880

  Fly  2049 LLQVLDELSQETPNDLLARELWCQAGNAAEWRQSVRRFVRCMSVMSMIGYVIGLGDRHLDNVLIN 2113
                   |..:...::              :..::..|.|..:...:..:::|:||||..|:::.
Zfish   881 -------LKDKNKGEM--------------YDMAIDLFTRSCAGYCVATFILGIGDRHNSNIMVK 924

  Fly  2114 LGSGDIVHIDYN--VCFEKGRTLRIPEKVPFRLTQNLVQAMGITGIE--------GPFRLGCEYV 2168
             ..|.:.|||:.  :..:|.:.....|:|||.|||:.:..:...|.:        ..|:..|...
Zfish   925 -DDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFLIVISKGGTQECTKTREFERFQEMCYKA 988

  Fly  2169 LKVMRKERETLLTLLEAFVYDPLVDWTTNDDAQALRR--SLNAKLQESAD 2216
            ...:|:.....:.|....:...:.:..:.||...:|:  :|:...||:.|
Zfish   989 YLAIRQHANLFINLFSMMLGSGMPELQSFDDIAYIRKTLALDKTEQEALD 1038

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nonC	NP_001284967.1	SMG1	571..1140	CDD:292413	7/29 (24%)
		Rapamycin_bind	1738..1845	CDD:285924	13/106 (12%)
		PIKKc_SMG1	1894..2196	CDD:270714	51/312 (16%)
		FATC	3189..3217	CDD:280430
pik3ca	XP_009304451.1	PI3K_p85B	31..108	CDD:197539
		PI3K_rbd	173..292	CDD:307097	20/119 (17%)
		C2_PI3K_class_I_alpha	325..484	CDD:176043	39/203 (19%)
		PI3Ka_I	529..696	CDD:238444	40/199 (20%)
		PKc_like	695..1065	CDD:328722	85/566 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900