DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nonC and PRKDC

DIOPT Version :9

Sequence 1:	NP_001284967.1	Gene:	nonC / 31625	FlyBaseID:	FBgn0263968	Length:	3218	Species:	Drosophila melanogaster
Sequence 2:	NP_008835.5	Gene:	PRKDC / 5591	HGNCID:	9413	Length:	4128	Species:	Homo sapiens

Alignment Length:	2182	Identity:	406/2182 - (18%)
Similarity:	738/2182 - (33%)	Gaps:	669/2182 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   381 GMPTCECIVKMAVDHLIKIMPTLHL----------NTEALVNINELICICL-------LNNFTGL 428
            |:|..|.:....::.|:|     |:          |.|.:..:.|....||       ...|:|.
Human  2204 GVPKDEVLANRLLNFLMK-----HVFHPKRAVFRHNLEIIKTLVECWKDCLSIPYRLIFEKFSGK 2263

  Fly   429 DPILLEQVLLDQVKRMISLTELQRQSVLYLLLCTVRRLRARLTPSLVHFIFQSNPY-------MT 486
            ||...:..:..|:..::...:|..    |...|.:                ||:.|       |:
Human  2264 DPNSKDNSVGIQLLGIVMANDLPP----YDPQCGI----------------QSSEYFQALVNNMS 2308

  Fly   487 KVRLRSPGETSYK---LLLRTCQETLLIRNVPL-------LQQAYKYLVDDIDACLEKLLITAPR 541
            .||.:.....:.:   |:||...|...|....|       |:|....:.|....||.|:..:.|.
Human  2309 FVRYKEVYAAAAEVLGLILRYVMERKNILEESLCELVAKQLKQHQNTMEDKFIVCLNKVTKSFPP 2373

  Fly   542 SKARKASVLLVFHLSALAALAKQTSSIIGMYACKPSILELLLTNCRAH---ELKFWSKYPAAQQA 603
            ...|        .::|:..|..:...::     |...||::|  ||..   ||.|..|
Human  2374 LADR--------FMNAVFFLLPKFHGVL-----KTLCLEVVL--CRVEGMTELYFQLK------- 2416

  Fly   604 IFGLLVVHCQANHNFRTNSSLLRDQELSAENTSPTANSFASILRF---------LDSVLGQAHQL 659
                                               :..|..::|.         ||.:.....:|
Human  2417 -----------------------------------SKDFVQVMRHRDDERQKVCLDIIYKMMPKL 2446

  Fly   660 APQNLRVLL----QWIQMLLRECREKI-DLLM-EQENFRGICRNIAATASKLVPLESAACIQTVL 718
            .|..||.||    :::......|||:: ::|| ..:|:|.........:.::..|.....||.::
Human  2447 KPVELRELLNPVVEFVSHPSTTCREQMYNILMWIHDNYRDPESETDNDSQEIFKLAKDVLIQGLI 2511

  Fly   719 DYGLERLEKYPKLLILYRD----------TALQQLQMLSTNYHAPYFQIY-----AQLPLHLTLT 768
            |       :.|.|.::.|:          ..|.:|..|::.| :|..:::     ....|.:|..
Human  2512 D-------ENPGLQLIIRNFWSHETRLPSNTLDRLLALNSLY-SPKIEVHFLSLATNFLLEMTSM 2568

  Fly   769 GGESSMPGMASRRVSVWQQRISQYS-----AVRDNVFRDFFDRVQKPEQDSLIHCLRE--LFVR- 825
            ..:...| |....:|  :....:|:     ..|..|....|...| ..|.:|....:|  |..|
Human  2569 SPDYPNP-MFEHPLS--ECEFQEYTIDSDWRFRSTVLTPMFVETQ-ASQGTLQTRTQEGSLSARW 2629

  Fly   826 --SCQV-APQDERQMNLSQCTKRCQRLAIAWLQFEAARYCVDQRLRTTVGKPQETFLGFEAIIMR 887
              :.|: |.|.:....|:|...  .|.:..||...:....||           .|....::::..
Human  2630 PVAGQIRATQQQHDFTLTQTAD--GRSSFDWLTGSSTDPLVD-----------HTSPSSDSLLFA 2681

  Fly   888 HARLLSGCAKEIERSALD------------------DLSLEELLSMQSNLSLLLGFLDALEKL-I 933
            |.|     ::.::|:.|.                  |..::........|.|...|:...||| :
Human  2682 HKR-----SERLQRAPLKSVGPDFGKKRLGLPGDEVDNKVKGAAGRTDLLRLRRRFMRDQEKLSL 2741

  Fly   934 YNAAEGSAFALRPPEKQVAAFFRLNNPTCQSWFNRIRIGVVIIAMHVQQPELVIRYAQQI--LVN 996
            ..|.:|.|...|  ||::.:..::........:...|        |...|::.|:::..|  |..
Human  2742 MYARKGVAEQKR--EKEIKSELKMKQDAQVVLYRSYR--------HGDLPDIQIKHSSLITPLQA 2796

  Fly   997 SKTQDPTYSQAIVYMAWSLVSCQEADSLRGLRLWARGKSCKSYKWLKYAADQAAGKRESALAGYR 1061
            ...:||..::.:....:|.: .:|.|.                                    ::
Human  2797 VAQRDPIIAKQLFSSLFSGI-LKEMDK------------------------------------FK 2824

  Fly  1062 TILAEKELQSELEPHTRQFV------VSQMMQCLQDLG-QWSQL--------------------- 1098
            |:..:..:..:|.....:|:      ....:.|:||:. |.:.|
Human  2825 TLSEKNNITQKLLQDFNRFLNTTFSFFPPFVSCIQDISCQHAALLSLDPAAVSAGCLASLQQPVG 2889

  Fly  1099 VELKQQQMTR--PEDRELNPFLQRSNVEVNALERL-LAKSEESCSSMDALGGVFQQLSLWPSNWD 1160
            :.|.::.:.|  |.:........::.:..:.|..: |||...|....|.|.|:|.
Human  2890 IRLLEEALLRLLPAELPAKRVRGKARLPPDVLRWVELAKLYRSIGEYDVLRGIFT---------- 2944

  Fly  1161 ESVSSSGLSERASFSSIHMRQRTEDIVLHKLLEDRCVP----DQAKNLLDTQWRDSLLNPSFDQR 1221
                          |.|..:|.|:..:|.:...|....    |:|.|..|  |.|.  .|:..::
Human  2945 --------------SEIGTKQITQSALLAEARSDYSEAAKQYDEALNKQD--WVDG--EPTEAEK 2991

  Fly  1222 SCKELTLL---RHIVQGVSGGQELSLLPVSSGRCQNRSKFISSAILMRCL------AWTQLLRQH 1277
            ...||..|   .|:.:..| .:..|...:.|....:.:|..|........      :..:||.|.
Human  2992 DFWELASLDCYNHLAEWKS-LEYCSTASIDSENPPDLNKIWSEPFYQETYLPYMIRSKLKLLLQG 3055

  Fly  1278 CAPGSWETLCLDAAAAAREEGNLQLAETLLTQFFGQPIGEIAALFSLEQGV-------QTDNPEM 1335
            .|..|..|. :|.|.    .|.||.|  :|...:.|   |::.|:.|:..|       |......
Human  3056 EADQSLLTF-IDKAM----HGELQKA--ILELHYSQ---ELSLLYLLQDDVDRAKYYIQNGIQSF 3110

  Fly  1336 LRGYSELVKCLH------LQQQQSQTH----------SGDLSSSIDVCAALCLNIQKSNNQPAAG 1384
            ::.||.:...||      ||..|:.|.          .|:|||.:.:  ...||.. :|..|.|.
Human  3111 MQNYSSIDVLLHQSRLTKLQSVQALTEIQEFISFISKQGNLSSQVPL--KRLLNTW-TNRYPDAK 3172

  Fly  1385 ADLLLNLADWIAVRTCNGLTTNQSPVLIQLLDQLPE-----CPLTCDSSQPLAIPQAERMVARLV 1444
            .| .:|:.|.|....|..|:.     :.:.|..|||     .....|.|..:.:.:.|..::.|:
Human  3173 MD-PMNIWDDIITNRCFFLSK-----IEEKLTPLPEDNSMNVDQDGDPSDRMEVQEQEEDISSLI 3231

  Fly  1445 HSC-----------LQQRPNYAEAL----------IAYGNWCYRWGKKVADSCC----------- 1477
            .||           .:::.|::.|:          ....:|...|    ..|.|
Human  3232 RSCKFSMKMKMIDSARKQNNFSLAMKLLKELHKESKTRDDWLVSW----VQSYCRLSHCRSRSQG 3292

  Fly  1478 ----VLTQADATAISQALDIPQPLESEKL---DE----------LLQALSTEQPPANCVEVCPDA 1525
                |||.....::....::...|....|   |:          :..|||:|  ||...|:..|.
Human  3293 CSEQVLTVLKTVSLLDENNVSSYLSKNILAFRDQNILLGTTYRIIANALSSE--PACLAEIEEDK 3355

  Fly  1526 ARARDDEAAKNRLRRLTFLADKTPEALDAILQIWRRAIANTYDYYKDAARSYFQYLSFKSGSGPE 1590
            ||           |.|......:.::...|..:::||               ||:||....:..|
Human  3356 AR-----------RILELSGSSSEDSEKVIAGLYQRA---------------FQHLSEAVQAAEE 3394

  Fly  1591 KPE--------GEGVV---------------SQRERLHVDDS-------NLVTTTL--------- 1616
            :.:        ..||:               .:.|...|.||       .||...:
Human  3395 EAQPPSWSCGPAAGVIDAYMTLADFCDQQLRKEEENASVIDSAELQAYPALVVEKMLKALKLNSN 3459

  Fly  1617 -------RLLRLIVKHASGLQEVLEQGLHTTPIAPWKVI--IPQLFSRLNHHEPY-VRKSVCDLL 1671
                   |||::|.::......::.:.:.:.|.  |:.|  |..:.:.|:..:.. |:.||.:
Human  3460 EARLKFPRLLQIIERYPEETLSLMTKEISSVPC--WQFISWISHMVALLDKDQAVAVQHSVEE-- 3520

  Fly  1672 CRLAKSRPQLVIFPAVVGANREQQDATAPPATARPTTEDACCYGYLLGELSKQAPEAVQHVKLMV 1736
              :..:.||.:::|.::.:.                     .|.:.......:..|.|..:|
Human  3521 --ITDNYPQAIVYPFIISSE---------------------SYSFKDTSTGHKNKEFVARIK--- 3559

  Fly  1737 KELRRVCLLWDEYWIHSLAHIYNTYVSRVSALATDFRPDDHEGKNNRFNVWRPQLLADLEALVAV 1801
            .:|.:..::.|  :|::|..:.|..:                    .|..|...:.|:| |...|
Human  3560 SKLDQGGVIQD--FINALDQLSNPEL--------------------LFKDWSNDVRAEL-AKTPV 3601

  Fly  1802 TSRPPETTYER--------------SFRKRFDAPIRLTVDALRHRRYPEAWDKL--------KQL 1844
            ..:..|..|||              :||::|........|    :.:.:...||        ..:
Human  3602 NKKNIEKMYERMYAALGDPKAPGLGAFRRKFIQTFGKEFD----KHFGKGGSKLLRMKLSDFNDI 3662

  Fly  1845 YHILQSNMIRGSGSTLKMQSISPVLCGIG----RMRISMPG-LDAHG---PDGDQVYIESVESSV 1901
            .::|...|.:.|.....::..||.:....    |..:.:|| .|..|   |: ..|.|...:..|
Human  3663 TNMLLLKMNKDSKPPGNLKECSPWMSDFKVEFLRNELEIPGQYDGRGKPLPE-YHVRIAGFDERV 3726

  Fly  1902 CVLPTKTKPKKVAFYGSNGQRYTFLFKGMEDLHLDERIMQFLSISNAIMACRSDAPGNGCYRAHH 1966
            .|:.:..:||::...|.:.:.:.||.||.|||..|:|:.|...:.|.|:| :..|......:...
Human  3727 TVMASLRRPKRIIIRGHDEREHPFLVKGGEDLRQDQRVEQLFQVMNGILA-QDSACSQRALQLRT 3790

  Fly  1967 YSVIPLGPQSGLISWVDGVTPVFAL-----------------------YKKWQQRRSQVAGNAGA 2008
            |||:|:..:.|||.|::....:..|                       ||.|   .::::|....
Human  3791 YSVVPMTSRLGLIEWLENTVTLKDLLLNTMSQEEKAAYLSDPRAPPCEYKDW---LTKMSGKHDV 3852

  Fly  2009 GAVANVPRRFTDLFYNKLSPLLAKHNMQVSDPRRQWPISVLLQVLDELSQETPNDLLARELWCQA 2073
            ||..        |.|..     |.....|:..|::             ..:.|.|||.| .:.:.
Human  3853 GAYM--------LMYKG-----ANRTETVTSFRKR-------------ESKVPADLLKR-AFVRM 3890

  Fly  2074 GNAAEWRQSVR-RFVRCMSVMSMIGYVIGLGDRHLDNVLINLGSGDIVHIDYNVCFEKG-RTLRI 2136
            ..:.|...::| .|....:::.:..:::|:|||||:|.::.:.:|.::.||:...|... :.|.:
Human  3891 STSPEAFLALRSHFASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQFLPV 3955

  Fly  2137 PEKVPFRLTQ---NLVQAMGITGIEGPFRLGCEYVLKVMRKERETLLTLLEAFVYDPLVDWTTND 2198
            ||.:|||||:   ||:..|..||:.....:   :.|:..|.:...|...::.||.:|..|| .|.
Human  3956 PELMPFRLTRQFINLMLPMKETGLMYSIMV---HALRAFRSDPGLLTNTMDVFVKEPSFDW-KNF 4016

  Fly  2199 DAQALRRSLNAKLQESADGGGAGGLGVGDLKYHKKDK 2235
            :.:.|::. .:.:||         :.|.:..::.:.|
Human  4017 EQKMLKKG-GSWIQE---------INVAEKNWYPRQK 4043

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nonC	NP_001284967.1	SMG1	571..1140	CDD:292413	109/664 (16%)
		Rapamycin_bind	1738..1845	CDD:285924	21/128 (16%)
		PIKKc_SMG1	1894..2196	CDD:270714	80/329 (24%)
		FATC	3189..3217	CDD:280430
PRKDC	NP_008835.5	HEAT 1	288..323
		HEAT 2	1004..1040
		Interaction with C1D. /evidence=ECO:0000269\|PubMed:9679063	1503..1538
		Leucine-zipper	1503..1538
		TPR 1	1723..1756
		NUC194	1816..2202	CDD:400469
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2050..2073
		KIP-binding	2436..3212		169/900 (19%)
		FAT	3023..3470	CDD:396714	96/497 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3200..3222		5/21 (24%)
		PIKKc_DNA-PK	3719..4015	CDD:270716	80/330 (24%)
		FATC	4097..4128	CDD:396715
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D26975at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910