DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment nonC and pi4kaa

DIOPT Version :9

Sequence 1:NP_001284967.1 Gene:nonC / 31625 FlyBaseID:FBgn0263968 Length:3218 Species:Drosophila melanogaster
Sequence 2:XP_009303356.1 Gene:pi4kaa / 556956 ZFINID:ZDB-GENE-100204-2 Length:2128 Species:Danio rerio


Alignment Length:2342 Identity:429/2342 - (18%)
Similarity:752/2342 - (32%) Gaps:786/2342 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   119 TINPMANGEDLRLSKIIRRLINENNPTVSLELCSKLDQAVRTPINMGYMTCSFVWILDNMLTLYK 183
            :::|:..|.            |....||.|:|..:|.|.|..     :::.||:..||..:|   
Zfish   291 SVSPLFTGS------------NNKEFTVPLDLLRQLLQMVEQ-----FVSESFMKTLDQAMT--- 335

  Fly   184 QCPPPVLEECSKTLGLIGFINRKSYPIYEEFIVKNYKSSKRMQKYMIMALRATLSCDTKCELHMY 248
                .|||           ||..:|..|:.|....|.:..:|.:..:..:: .|......|:|  
Zfish   336 ----EVLE-----------INPTAYLYYKTFSDPLYVAIFKMLRDSLYYMK-DLQVSFVKEVH-- 382

  Fly   249 ADKIMLLLKDFLENAESADIFIVVSNTLVQFAASYAE------------------TFECHFTDV- 294
                     ||:               |.||::|.:|                  ...|..... 
Zfish   383 ---------DFV---------------LEQFSSSQSELQRILHDVEYLHSELNPLKLRCQANAAC 423

  Fly   295 VDIVIGWQLEAGQPTD-LKTHCAQVLEQLTPFFSKQIDFSYGLLDQFVEDITTLEEGEPANTAER 358
            ||::: |.:...|..: |.|..::.|:..|.  ||.|.....||...::.:..|.|..|      
Zfish   424 VDLMV-WAVTEEQGAENLCTKLSEKLQSKTS--SKVIIAHMPLLICCLQGLGRLCERFP------ 479

  Fly   359 VGAFVGAFNTLLKCLARMQIFVGMPTCECIVKMAVDHL--------IKI---------------- 399
                |.|.:..:.    ::.|:.:|: ..:||:...|.        |||                
Zfish   480 ----VVAHSVTMS----LRDFLVVPS-PVLVKLYKYHSQYTTGAGEIKIHVTNEHSQSTFSSHSS 535

  Fly   400 ---MPTLHLNTEAL--VNINELICICLLNNFTGLDPILLEQVLLDQVKRMISLTELQRQSVLYLL 459
               .|:::   |.|  ::||. ||.||....| :|.:::|..|.....|:....|..:.:.| :.
Zfish   536 KKSQPSMY---EQLRDISINN-ICRCLKAGLT-MDSVIVEAFLASLSNRLYISQENDKDAHL-IP 594

  Fly   460 LCTVRRL-----RARLTPSLVHFIFQSNPYMTKVRLRSPGETSYKLLLRTCQETLLIRNVPLLQQ 519
            ..|:|.|     ..|.||.::..|.|    :.:.:...|......|::......::..|..:.|:
Zfish   595 DHTIRALGHIAVALRDTPRVMEPILQ----ILQQKFCQPPSQLDVLIIDQLGCMVITGNQYIYQE 655

  Fly   520 AYKYLVDDIDACLEKLLITAPRSK---ARKASVLLVFHLSALAALAK--QTSSIIGMYACKPSIL 579
            .:. |...|......::.:....|   .|..|:.::   :|||.:|.  ||..::.....  ::|
Zfish   656 VWN-LFQQISVKASSMVYSTKDYKDHGYRHCSLAVI---NALANIAANLQTEQMVDELLV--NLL 714

  Fly   580 ELL----LTNCRAHELKFWSKYPAAQQAIFGLLVVHCQANHNFRTNSSLLRDQELSAENTSPTAN 640
            ||.    |...||.| :...|.||                              |.|.:::....
Zfish   715 ELFVQLGLEGKRASE-RASEKGPA------------------------------LKASSSAGNLG 748

  Fly   641 SFASILRFLDSVLGQAHQLAPQNLRVLLQ--WIQMLLRECREKIDLLMEQENFRGICRNIAATAS 703
            ....::..|...|....:..|: |:.|.:  |:..::.....:...|..:|.:.|:|.  .||.|
Zfish   749 VLIPVIAVLTKRLPAIKEAKPR-LQKLFRDFWLYSVVMGFAVEGSGLWPEEWYEGVCE--IATKS 810

  Fly   704 KLVPLESAACIQTVLDYG--------------------LERLEKYPKLLILYRDTALQQLQMLST 748
            .|:...|...:::.|.|.                    :..|:..|::..|...........|.:
Zfish   811 PLLTFPSGEPLRSELQYNSALKNDTVTPAELNDLRGTIINLLDPPPEVAALINKLDFAMSTYLLS 875

  Fly   749 NYHAPYFQIYAQLPLHLTLTGGESSMPGMASRRVSVWQQRISQYSAVRDNVFRDFFDRVQKPEQD 813
            .|...|.::                :....|.|..|              :||.|.||..:.::.
Zfish   876 VYRLEYMRV----------------LRSQESDRFQV--------------MFRYFEDRAIQKDKS 910

  Fly   814 SLIHC------------LRELFVRSCQVAPQDERQ-------MNLSQCTKRCQRLAIAWLQFEAA 859
            .::.|            |:.:..::...|.::|.:       :|.:...||.:|:|..:|...|.
Zfish   911 GMMQCVIAVGDKVFDVFLQMMADKAKTKAHEEELESHAQFLLVNFNHIHKRIRRVADKYLSGLAE 975

  Fly   860 RY------------------CVDQRLRTTVGKPQ---------------ETFLGFEAIIMRHARL 891
            .:                  .:...|...:.|.|               :|:...|:|:...|..
Zfish   976 TFPHLLWSGRVLRTMLDILQTLSLSLSADIHKDQPYYDIPDTPYRITVPDTYEARESIVKDFAAR 1040

  Fly   892 LSGCAKEIERSA--LDDLSLEELLSMQSN----LSLLLGFLDALEKLI----YNAAEGSAFALRP 946
            .....||..:.|  :....|:|.|:...|    ||...|...|.|.::    ||....|....:.
Zfish  1041 CGEILKEAMKWAPSVTKSHLQEYLNKHQNWVSGLSQHTGLAMATESILHFAGYNRQSTSLGTTQL 1105

  Fly   947 PEKQVAAFFRLNNPTC--QSWFN-------RIR-IGVVIIAMHVQQP--------ELVIRYAQQI 993
            .|:          |.|  :.:.|       |.| .|.|...:|..:.        :|:||...:.
Zfish  1106 TER----------PACVKKDYSNFMASLNLRNRYAGEVAGMIHFSEATRSTSDLNKLMIRQMNEA 1160

  Fly   994 LVNSKTQDPTYSQAIVYMAWSLVSCQEADSLRGLRL-WARGKSCKSYKWLKYAADQAAGKRESAL 1057
            |...  |...:::|:..||..|:|.:|.|.|....| |:.         ||...:..   .|:|:
Zfish  1161 LDGG--QPEAFTEALFKMAALLISSREWDPLLLHHLCWSP---------LKMFTENG---METAI 1211

  Fly  1058 AGYRTILAEKELQSELE-PHTRQFVVSQMMQCLQDLGQWSQLVELKQQQMTRPEDRELNPFLQRS 1121
            |.:..:||.:   :.:| |..|:..           |.|...|:||....:..: .|.:|     
Zfish  1212 ACWEWLLAGR---TGVEVPFMREMA-----------GAWQMTVDLKMGLFSDAQ-LEADP----- 1256

  Fly  1122 NVEVNALERLLAKSEESCSSMDALGGVFQQLSLWPSNWDESVSSSGLSERASFSSIHMRQRTEDI 1186
                      ||.||||           |.:...|......:....|.:|...:......:.|  
Zfish  1257 ----------LAASEES-----------QPIPCPPDVTPHYIWIEFLVQRFEIAKYSSADQVE-- 1298

  Fly  1187 VLHKLLEDRCVPDQAKNLLDTQWRDSLLNPSFDQRSCKELTLLRHIVQGVSGGQELSLLPVSSGR 1251
            :...||:                |...||....:.|     |.||:   .:.|....||.:  |.
Zfish  1299 IFGSLLQ----------------RSLSLNVGSPKSS-----LNRHV---AAIGPRFRLLTL--GL 1337

  Fly  1252 CQNRSKFISSAILMRCLAWTQLLRQHCAPGSWETLCLDAAAAAREEGNLQLAE--TLLTQFFGQ- 1313
            ....|..:::|.:      ..:||:.....:::  ....|:....:|:.:|.|  :::.:|:.. 
Zfish  1338 SLLHSDVVTNATI------RNVLREKIYSTAFD--YFSVASKFPTQGDKRLREDISIMIRFYASI 1394

  Fly  1314 -------------PIGEIAALFSLEQGVQTDNPEMLRGYSELVKCLHLQQQQSQTHSGDLSSSID 1365
                         |.||:.|           ||                 .||...:|...|.| 
Zfish  1395 LSDKKYLGASLLVPPGELGA-----------NP-----------------PQSSLSAGIFGSLI- 1430

  Fly  1366 VCAALCLNIQKSNNQPAAGADLLLNLADWIAVRTCNGLTTNQSPVLIQL-----LDQLPECPLTC 1425
                      .|:..|.:    :||               ||.|.|..|     .|......:|.
Zfish  1431 ----------VSSTSPIS----ILN---------------NQDPSLNSLSVMNATDPRNNMDMTV 1466

  Fly  1426 DSSQPLA------IPQAERMVARLVHSCLQQRPNYAEALIAYGNWCYRWGKKVADSCCVLTQADA 1484
            .|.|..|      .|.:..|......|.:.::.|....|..|      :.|:......:|..   
Zfish  1467 GSRQQSAQGWINTYPLSSGMSTTSKKSGMSKKSNRGTQLHKY------YMKRRTLLLALLAS--- 1522

  Fly  1485 TAISQALDIPQPLESEKLDELLQALSTEQPPANCVEVCPDAARARDDEAAKNRLRRLTFLADKTP 1549
                         |.|:|......|||::                              ||..|.
Zfish  1523 -------------EIERLSTWYNPLSTQE------------------------------LAIPTE 1544

  Fly  1550 EALDAILQIWRRAIAN-TYDYYKD---AARSYFQYLS------FKSGSGPEKPEGEGVVSQRERL 1604
            ::::..:..||....| |...:||   .|.|...||:      ||:...                
Zfish  1545 QSVETSISNWRSKYINLTEKQWKDNVNLAWSIAPYLALQLPARFKNADA---------------- 1593

  Fly  1605 HVDDSNLVTTTLRLLRLIVKHASGLQEVLEQGLHTTPIAPWKVI---IPQLFSRLNHHEPYVRKS 1666
                  :|....||:||.....|.:.|.::.      :..|..|   .|:    |:|        
Zfish  1594 ------IVAEVTRLVRLDPGAVSDVPEAVKF------LVTWHTIDADSPE----LSH-------- 1634

  Fly  1667 VCDLLCRLAKSRPQ-LVIFPAVVGANREQQDATAPPATARPTTEDACCYGYLLGELSKQAPEAVQ 1730
               :||......|. |..|.::.           ||   .|.|..   ||..:  |....|:|:.
Zfish  1635 ---ILCWAPADPPTGLSYFSSMY-----------PP---HPLTAQ---YGVKV--LRSFPPDAIL 1677

  Fly  1731 -HVKLMVKELR-------RVCLLWDEYWIHSLAH--IYNTYVSRVSALATDFRPDDHEGKNNRFN 1785
             ::..:|:.||       |..:||.......|||  |:|        :.|:...|: ||.....:
Zfish  1678 FYIPQIVQALRYDKMGYVREYILWAAQKSQLLAHQFIWN--------MKTNIFLDE-EGHQKDPD 1733

  Fly  1786 VWRPQLLADL-EALVAVTSRPPETTYERSFRKRFDAPIRLT-VDAL---------RHRRYPEAWD 1839
            :  .:||..: |.:....|.|.:..|:|    .||...::| |.|:         |.|...:|..
Zfish  1734 I--GELLEQMVEEITHSLSGPAKDFYQR----EFDFFNKITNVSAIIKPVPKGDERKRACLKALS 1792

  Fly  1840 KLK-QLYHILQSN-------MIRGSGSTLKMQSISPVL-------CGIGRMRISMPGLDAHGPDG 1889
            ::| |....|.||       :...||:.::..:.:|.|       ||:.  .:...||.......
Zfish  1793 EIKVQPGCYLPSNPEAIVLDIDYKSGTPMQSAAKAPYLAKFKVKRCGVS--ELEKEGLRCPSDSQ 1855

  Fly  1890 DQVYIESVESSVCVLPTKTKPKKVAFYGSNGQRYTFLFKGMEDLHLDERIMQFLSISNAIMACRS 1954
            |    |..|||:..       ::|.:..:       :||..:|...|...:|.:.:...|.    
Zfish  1856 D----EGDESSLTA-------QRVCWQAA-------IFKVGDDCRQDMLALQIIGLFKNIF---- 1898

  Fly  1955 DAPGNGCYRAHHYSVIPLGPQSGLISWVDGVTPVFALYKKWQQRRSQVAGNAGAGAVANVPRRFT 2019
            ...|...: ...|.|:...|..|:|..:...           :.|.|:......|        ..
Zfish  1899 QLVGLDLF-VFPYRVVATAPGCGVIECIPDC-----------KSRDQLGRQTDFG--------MY 1943

  Fly  2020 DLFYNKLSPLLAKHNMQVSDPRRQWPISVLLQVLDELSQETPNDLLARELWCQAGNAAEWRQSVR 2084
            |.|.|                          |..||                   :...::::..
Zfish  1944 DYFRN--------------------------QYGDE-------------------STLAFQKARY 1963

  Fly  2085 RFVRCMSVMSMIGYVIGLGDRHLDNVLINLGSGDIVHIDYNVCFEKGRTLRIPEKVPFRLTQNLV 2149
            .|:|.|:..|::.:::.:.|||..|:::: ..|.::|||:...||......:..:...:||..:|
Zfish  1964 NFIRSMAAYSLLLFLLQIKDRHNGNIMLD-SKGHLIHIDFGFMFESSPGGNLGWEPDIKLTDEMV 2027

  Fly  2150 QAMGITGIEGPFRLGCEYVLK---VMRKERETLLTLLEAFVYDPLVDWTTNDDAQALRRSLNAKL 2211
            ..||......||:...|..::   .:|...:.:::|: ..:.|..:........:.|::..|..:
Zfish  2028 MIMGGKMEATPFKWFMEMCVRGYLAVRPYMDAVVSLV-TLMLDTGLPCFRGQTIKLLKQRFNPNM 2091

  Fly  2212 QE 2213
            .|
Zfish  2092 SE 2093

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nonCNP_001284967.1 SMG1 571..1140 CDD:292413 123/676 (18%)
Rapamycin_bind 1738..1845 CDD:285924 31/127 (24%)
PIKKc_SMG1 1894..2196 CDD:270714 51/304 (17%)
FATC 3189..3217 CDD:280430
pi4kaaXP_009303356.1 PI4Ka 1573..1748 CDD:238443 50/247 (20%)
PI4Kc_III_alpha 1809..2127 CDD:270711 63/376 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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