DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nonC and ATR

DIOPT Version :9

Sequence 1:	NP_001284967.1	Gene:	nonC / 31625	FlyBaseID:	FBgn0263968	Length:	3218	Species:	Drosophila melanogaster
Sequence 2:	XP_011511226.1	Gene:	ATR / 545	HGNCID:	882	Length:	2646	Species:	Homo sapiens

Alignment Length:	2725	Identity:	531/2725 - (19%)
Similarity:	915/2725 - (33%)	Gaps:	946/2725 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 GSGNIAGLGGS--ESMWSPGGGKSHDVAQAFANALLLRNMNHVVGKGQPVVQNHRKAYQCKGDTI 120
            ||..|..|..|  ..::..||..:...:..|::.|.|  :.|:|    .:..:..|.|:
Human   240 GSPKIKSLAISFLTELFQLGGLPAQPASTFFSSFLEL--LKHLV----EMDTDQLKLYE------ 292

  Fly   121 NPMANGEDLRLSKIIRRLI------NENNPTVSL-----ELCSKLDQAVRTPINMGYMTCSFVWI 174
            .|        |||:|:.|.      ..|...|.|     :||...:..|...:....:..:
Human   293 EP--------LSKLIKTLFPFEAEAYRNIEPVYLNMLLEKLCVMFEDGVLMRLKSDLLKAA---- 345

  Fly   175 LDNMLTLYKQCPPPVLEE------------CSKTLGLIGF--------------INRKSYPIYEE 213
            |.::|..:.:..|...|.            |...|.::|.              :..:|..|.||
Human   346 LCHLLQYFLKFVPAGYESALQVRKVYVRNICKALLDVLGIEVDAEYLLGPLYAALKMESMEIIEE 410

  Fly   214 FIVKNYKSSKRMQKYMIMALRATLSC----------DTKCELHMYADKIMLLLKDFLENAESADI 268
            ...:..:.:.......|...|..||.          .|:...|:..::..:|.....:.|||..|
Human   411 IQCQTQQENLSSNSDGISPKRRRLSSSLNPSKRAPKQTEEIKHVDMNQKSILWSALKQKAESLQI 475

  Fly   269 FIVVS---NTLVQFAASYA---------------ETFECH-FTDV-------VDIVIGWQ----- 302
            .:..|   |.:::.....|               :...|. |.|.       ..:||.|.
Human   476 SLEYSGLKNPVIEMLEGIAVVLQLTALCTVHCSHQNMNCRTFKDCQHKSKKKPSVVITWMSLDFY 540

  Fly   303 ----------LEAGQPTDLKTHCAQVLEQLTPFFSKQIDFSYGLLDQFVEDITTL---------- 347
                      ||:.|..||:....:|::........|::.|:.  |..:||:..:
Human   541 TKVLKSCRSLLESVQKLDLEATIDKVVKIYDALIYMQVNSSFE--DHILEDLCGMLSLPWIYSHS 603

  Fly   348 EEGEPANTAERVGAFVGAFNTLLKCLARMQIFVGMPTCECIVKMAVD--------HLIKIMPT-- 402
            ::|                     ||........:.|..|.:..:..        .|:.:.|.
Human   604 DDG---------------------CLKLTTFAANLLTLSCRISDSYSPQAQSRCVFLLTLFPRRI 647

  Fly   403 -LHLNTE----ALVNINELICICLLNNFTGLDPILLEQ---------VLLDQVKRMISLTELQRQ 453
             |...|.    ||.:.:|:|....::.|.    |||:|         :|:|:||....:.:.:..
Human   648 FLEWRTAVYNWALQSSHEVIRASCVSGFF----ILLQQQNSCNRVPKILIDKVKDDSDIVKKEFA 708

  Fly   454 SVLYLLLCTV------------------------RRLRA---------RLTPSLVH-FIFQSNPY 484
            |:|..|:||:                        |.|:|         :|..|:.. |:|
Human   709 SILGQLVCTLHGMFYLTSSLTEPFSEHGHVDLFCRNLKATSQHECSSSQLKASVCKPFLF----- 768

  Fly   485 MTKVRLRSP--------------------GETSYKLLLRT------------------------- 504
            :.|.::.||                    .||..|.:|.|
Human   769 LLKKKIPSPVKLAFIDNLHHLCKHLDFREDETDVKAVLGTLLNLMEDPDKDVRVAFSGNIKHILE 833

  Fly   505 --------CQETLLIRNVPLLQQAYKY--------LVDDIDACLEKLLITAPRSKARKASVLLVF 553
                    .:|..::|    :::||.:        |.|.:      :|.|....:|.|..::...
Human   834 SLDSEDGFIKELFVLR----MKEAYTHAQISRNNELKDTL------ILTTGDIGRAAKGDLVPFA 888

  Fly   554 HLSALAALAKQTSSIIGMYACKPSILELLLTNCRAHELK---FWSKY--PAAQQAIFGLLVVHCQ 613
            .|..|..|..:::|:.|  |....|..|:    .|..:|   |:|:|  |..|..:..|......
Human   889 LLHLLHCLLSKSASVSG--AAYTEIRALV----AAKSVKLQSFFSQYKKPICQFLVESLHSSQMT 947

  Fly   614 ANHNFRTNSSLLRDQELS-----AENT-SPTAN--SFASILRFLDSVL--------GQAHQLAPQ 662
            |..|....::.:|.|:::     |.|| |..||  .|..:.|||...|        .:|...|..
Human   948 ALPNTPCQNADVRKQDVAHQREMALNTLSEIANVFDFPDLNRFLTRTLQVLLPDLAAKASPAASA 1012

  Fly   663 NLRVLLQWIQMLLRECREKIDLLMEQENFRGICRNIAATASKLVPLESAACI---QTVLDYGLER 724
            .:|.|.:.:.:..||      :|:  .||:.|..::..:.|| ..||.|...   :|.::.|...
Human  1013 LIRTLGKQLNVNRRE------ILI--NNFKYIFSHLVCSCSK-DELERALHYLKNETEIELGSLL 1068

  Fly   725 LEKYPKL---LILYRDTALQQL---------------------QMLSTNYHAPYFQ-----IYAQ 760
            .:.:..|   |:|......||:                     .::|....|.|.|     |.|.
Human  1069 RQDFQGLHNELLLRIGEHYQQVFNGLSILASFASSDDPYQGPRDIISPELMADYLQPKLLGILAF 1133

  Fly   761 LPLHLTLTGGESSMPGMASRRVS---------------VWQQRISQYSAVRDNV-FRDFFDRVQK 809
            ..:.|.     ||..|:..::::               |...|:...:.:|..: |:|.|..:..
Human  1134 FNMQLL-----SSSVGIEDKKMALNSLMSLMKLMGPKHVSSVRVKMMTTLRTGLRFKDDFPELCC 1193

  Fly   810 PEQDSLIHCLRELFVRS------------CQVAPQD----------------------------- 833
            ...|..:.||....:.|            ..:.|::
Human  1194 RAWDCFVRCLDHACLGSLLSHVIVALLPLIHIQPKETAAIFHYLIIENRDAVQDFLHEIYFLPDH 1258

  Fly   834 -----------ERQMNLSQCT--KRCQRLAIAWLQFEAARYCVDQR------LRTTVGKPQETFL 879
                       |.:...|:.|  :...:|::..:|.|.    ||.|      |:.|:.|.||..:
Human  1259 PELKKIKAVLQEYRKETSESTDLQTTLQLSMKAIQHEN----VDVRIHALTSLKETLYKNQEKLI 1319

  Fly   880 GF-------EAIIMR--------------HARLLSG-CAKEIERSALD----DLSLEELLSMQ-- 916
            .:       |.||.:              .||||.| |..|:  .|:|    |.|..|.....
Human  1320 KYATDSETVEPIISQLVTVLLKGCQDANSQARLLCGECLGEL--GAIDPGRLDFSTTETQGKDFT 1382

  Fly   917 -------SNLSLLLGFLDALEK--LIY----NAAEGSAFALRPPEKQVAAFF-----RLNNPTCQ 963
                   .:.|...|.|..|.:  |.|    .|.:.:|:|:    :::.:.:     ..|.|..|
Human  1383 FVIETGVEDSSFAYGLLMELTRAYLAYADNSRAQDSAAYAI----QELLSIYDCREMETNGPGHQ 1443

  Fly   964 SWFNRIRIGVVIIAMHVQ---QPELVIRYAQQILVNSKTQDPTYSQAIVYMAWSLVSCQEADSLR 1025
            .|..        ...||:   :|.|..||..    :.|:.|.:..:..:|:  |.:....|:
Human  1444 LWRR--------FPEHVREILEPHLNTRYKS----SQKSTDWSGVKKPIYL--SKLGSNFAE--- 1491

  Fly  1026 GLRLWARGKSCKSYKWLKYAADQAAGKRESALAGYRTILAEKELQSE--LEPH------------ 1076
                |       |..|..|...:......|.:....:|:.:.:.:..  |.||
Human  1492 ----W-------SASWAGYLITKVRHDLASKIFTCCSIMMKHDFKVTIYLLPHILVYVLLGCNQE 1545

  Fly  1077 TRQFVVSQMMQCL----------QDLGQWSQLVELKQQQMTRPEDRELNPFLQRSNVEVNALERL 1131
            .:|.|.:::|..|          ||:.  |.|.:|..|.:          |....::...|..:.
Human  1546 DQQEVYAEIMAVLKHDDQHTINTQDIA--SDLCQLSTQTV----------FSMLDHLTQWARHKF 1598

  Fly  1132 LAKSEESC-------SSMDAL---------GGVFQQLSLWPSNWDESVSSSGLSERASFSSIH-- 1178
            .|...|.|       :.:|::         ..|.:.|.|.|.  |....:|..|:..:.:.:|
Human  1599 QALKAEKCPHSKSNRNKVDSMVSTVDYEDYQSVTRFLDLIPQ--DTLAVASFRSKAYTRAVMHFE 1661

  Fly  1179 --MRQRTEDI-----VLHKL----------------------LEDRCVPDQAKNLLDTQWRDSLL 1214
              :.::.::|     .|.||                      |:::.:..::..||    ||:
Human  1662 SFITEKKQNIQEHLGFLQKLYAAMHEPDGVAGVSAIRKAEPSLKEQILEHESLGLL----RDA-- 1720

  Fly  1215 NPSFDQRSCKELTLLRH---IVQGVSG-GQELSLLPVSSGRCQNRSKFISSAILMRCLAWTQLLR 1275
            ...:|:....|...:.|   :|:.:.| ||..:::...:|...|||:            ||..|.
Human  1721 TACYDRAIQLEPDQIIHYHGVVKSMLGLGQLSTVITQVNGVHANRSE------------WTDELN 1773

  Fly  1276 QHCAPGSWETLCLD------AAAAAREEGNLQLAETLL-------TQFF-------GQPIGEIAA 1320
            .:....:|:....|      ||.......:::|.:.||       |.|:       .:.|..::|
Human  1774 TYRVEAAWKLSQWDLVENYLAADGKSTTWSVRLGQLLLSAKKRDITAFYDSLKLVRAEQIVPLSA 1838

  Fly  1321 LFSLEQGVQTDNPEMLRGYSELVKCLHLQQQQSQT------HS-GDLS--SSIDVCAALCLNIQK 1376
            . |.|:|      ...|||..:|: ||:..:...:      || ||.|  .|::..|.|    :.
Human  1839 A-SFERG------SYQRGYEYIVR-LHMLCELEHSIKPLFQHSPGDSSQEDSLNWVARL----EM 1891

  Fly  1377 SNNQPAAGADLLLNLADWIAVRTCNGLTTNQSPVLIQLLDQLPECPLTCDSSQPLAIPQAERMVA 1441
            :.|...|...:|       |:|... |:.|:.|   ...:.:.||.|           |:.|:..
Human  1892 TQNSYRAKEPIL-------ALRRAL-LSLNKRP---DYNEMVGECWL-----------QSARVAR 1934

  Fly  1442 RLVHSCLQQRPN---------YAEALIAYGNWCYRWGKKVADSCCVLTQADATAISQALDIPQPL 1497
            :..|.  |...|         .||..:....|.  |.|.......::.|       :.:::..|
Human  1935 KAGHH--QTAYNALLNAGESRLAELYVERAKWL--WSKGDVHQALIVLQ-------KGVELCFP- 1987

  Fly  1498 ESEKLDELLQALSTEQPPANCVEVCPDAARARDDEAAKNRL---RRL----TFLADKTPEALDAI 1555
                        ..|.||                 ..||.|   |.:    .|:.:......:||
Human  1988 ------------ENETPP-----------------EGKNMLIHGRAMLLVGRFMEETANFESNAI 2023

  Fly  1556 LQIWRRAIA---NTYDYYKDAARSYFQYLSFKSGSGPEKPEGEGVVSQRERLHVDDSNLVTTTLR 1617
            ::.::...|   ...|.:...|:.|.:.:...:.:..|| :|:
Human  2024 MKKYKDVTACLPEWEDGHFYLAKYYDKLMPMVTDNKMEK-QGD---------------------- 2065

  Fly  1618 LLRLIVKHASGLQEVLEQGLHTTPIAPWKVIIPQLFSR-LNHHEPYVRKSVCDLLCRLAKSRPQL 1681
            |:|.||.|                           |.| |.:...::.:|:           |::
Human  2066 LIRYIVLH---------------------------FGRSLQYGNQFIYQSM-----------PRM 2092

  Fly  1682 VIFPAVVGANREQQDATAPPATARPTTEDACCYGYLLGELSKQAPE------AVQHVKLMVKELR 1740
            :......|....:.:........:...:        ||:::|...|      ..|.:....:.:.
Human  2093 LTLWLDYGTKAYEWEKAGRSDRVQMRND--------LGKINKVITEHTNYLAPYQFLTAFSQLIS 2149

  Fly  1741 RVCLLWDEYWI---HSLAHIYNTYVSRVSALATDFRPDDHEGKNNRFNVWRPQLLADLEALVAVT 1802
            |:|...||.::   ..:|.::..|..:...:.|......:..:.||..          |.|....
Human  2150 RICHSHDEVFVVLMEIIAKVFLAYPQQAMWMMTAVSKSSYPMRVNRCK----------EILNKAI 2204

  Fly  1803 SRPPETTYERSFRKRFDAPIRLTVDALRHRRYPEAWDKLKQLYHILQSNMIRGSGSTLKMQ---- 1863
            .      .::|..|......|||             |||.:|.    :..:.||.|||.|.
Human  2205 H------MKKSLEKFVGDATRLT-------------DKLLELC----NKPVDGSSSTLSMSTHFK 2246

  Fly  1864 ---------SISPVLCGIGRMRI-SMPGL-------DAHGP-DGDQVYIESVESSVCVLPTKTKP 1910
                     :.|.:|..:..:.| ::|.:       .:|.| .|...||...:..|.:|.:..||
Human  2247 MLKKLVEEATFSEILIPLQSVMIPTLPSILGTHANHASHEPFPGHWAYIAGFDDMVEILASLQKP 2311

  Fly  1911 KKVAFYGSNGQRYTFLFKGMEDLHLDERIMQFLSISNAIMACRSDAPGNGCYRAHH---YSVIPL 1972
            ||::..||:|:.|..:.|..:||..|.|:|:|.|:.|..:  |.||...  .|..|   |:||||
Human  2312 KKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNSLINKCL--RKDAESR--RRELHIRTYAVIPL 2372

  Fly  1973 GPQSGLISWVD---GVTPVFA-LYKK-------WQQRRSQVAGNAGAGAVANVPRRFTDLFYNKL 2026
            ..:.|:|.||:   |:.|:.. |||:       .:.|:..:..:|.......|.|.|
Human  2373 NDECGIIEWVNNTAGLRPILTKLYKEKGVYMTGKELRQCMLPKSAALSEKLKVFREF-------- 2429

  Fly  2027 SPLLAKHNMQVSDPRRQWPISVLLQVLDELSQETPNDLLARELWCQAGNAAEWRQSVRRFVRCMS 2091
              ||.:|.                .:..|....|..|            ...|..|...:.|..:
Human  2430 --LLPRHP----------------PIFHEWFLRTFPD------------PTSWYSSRSAYCRSTA 2464

  Fly  2092 VMSMIGYVIGLGDRHLDNVLINLGSGDIVHIDYNVCFEKGRTLRIPEKVPFRLTQNLVQAMGITG 2156
            ||||:||::||||||.:|:|.:..:|:.||:|:|..|.||.|..:||.||||||.|:|..||..|
Human  2465 VMSMVGYILGLGDRHGENILFDSLTGECVHVDFNCLFNKGETFEVPEIVPFRLTHNMVNGMGPMG 2529

  Fly  2157 IEGPFRLGCEYVLKVMRKERETLLTLLEAFVYDPLVDWTTNDDAQALRRSLNAKLQESAD 2216
            .||.||..||..:::||.:||.|:::|:.|::||||:|     ::.::....|.|.|:.:
Human  2530 TEGLFRRACEVTMRLMRDQREPLMSVLKTFLHDPLVEW-----SKPVKGHSKAPLNETGE 2584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nonC	NP_001284967.1	SMG1	571..1140	CDD:292413	146/777 (19%)
		Rapamycin_bind	1738..1845	CDD:285924	19/109 (17%)
		PIKKc_SMG1	1894..2196	CDD:270714	107/315 (34%)
		FATC	3189..3217	CDD:280430
ATR	XP_011511226.1	UME	1119..1224	CDD:214825	19/109 (17%)
		FAT	1773..2094	CDD:280429	78/456 (17%)
		TEL1	<2135..2646	CDD:227365	145/530 (27%)
		PIKKc_ATR	2295..2569	CDD:270625	107/320 (33%)
		FATC	2615..2646	CDD:280430
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900