Protein Alignment nonC and PI4KA

DIOPT Version :9

• Sequence 1: NP_001284967.1
• Gene: nonC / 31625
• FlyBaseID: FBgn0263968
• Length: 3218
• Species: Drosophila melanogaster
• Sequence 2: NP_477352.3
• Gene: PI4KA / 5297
• HGNCID: 8983
• Length: 2102
• Species: Homo sapiens
• Alignment Length: 2616
• Identity: 448/2616 - (17%)
• Similarity: 783/2616 - (29%)
• Gaps: 1062/2616 - (40%)

  Fly    45 GGGGNGSGRGGATGSGNIAGLG------------------------------------------- 66
            ||||.|.|.||.:|||:.|..|
Human     8 GGGGGGGGGGGCSGSGSSASRGFYFNTVLSLARSLAVQRPASLEKVQKLLCMCPVDFHGIFQLDE 72

  Fly    67 ----------------------------------------GSESMWSPGGGKSHDVAQAFANAL- 90
                                                    ..||....|.| :..||::|:..|
Human    73 RRRDAVIALGIFLIESDLQHKDCVVPYLLRLLKGLPKVYWVEESTARKGRG-ALPVAESFSFCLV 136

  Fly    91 --------------------LLRNMNHVVGKGQPV-VQNHRKAYQCK---------GDTINPMAN 125
                                ||:.::.::|..|.: :|:  |.|.||         .......:|
Human   137 TLLSDVAYRDPSLRDEILEVLLQVLHVLLGMCQALEIQD--KEYLCKYAIPCLIGISRAFGRYSN 199

  Fly   126 GEDLRLSKIIRRLINENNPTVSLELCSKLDQAVRTPINMGYMTCSFVWIL-DNMLTLYKQCPPPV 189
            .|:..|||:..::     |..||.:..:|:...|...|      .|..|| .|:||:   |....
Human   200 MEESLLSKLFPKI-----PPHSLRVLEELEGVRRRSFN------DFRSILPSNLLTV---CQEGT 250

  Fly   190 LEECSKTLGLIGFINRK------SYP---IYEEFIVKNYKSSKRMQ-KYMIMALRATLSCD---- 240
            |:..:.::..|..::.:      |.|   .:..|..........:: :|....:.::.|..
Human   251 LKRKTSSVSSISQVSPERGMPPPSSPGGSAFHYFEASCLPDGTALEPEYYFSTISSSFSVSPLFN 315

  Fly   241 --TKCELHMYAD---KIMLLLKDFLENAESADIFIVVSNTLVQFAASYAETFECHFTDVVDIVIG 300
              |..|.::..:   :::.|:|..:|.|....:..:|::  |..|...|:.:...|:|.:.:.:.
Human   316 GVTYKEFNIPLEMLRELLNLVKKIVEEAVLKSLDAIVAS--VMEANPSADLYYTSFSDPLYLTMF 378

  Fly   301 WQLEAGQPT-----DLKTHCAQVLEQLTPFFSKQIDFSYGLLDQFVEDITTLEEGEPANTAERVG 360
            ..|   :.|     ||.|   ..::::..|..:|.:.|.|.|.:.:.|            |:|:
Human   379 KML---RDTLYYMKDLPT---SFVKEIHDFVLEQFNTSQGELQKILHD------------ADRI- 424

  Fly   361 AFVGAFNTL----LKCLARMQIFVGMPTCECIVKMAV------DHL-IKIMPTLHLNTEALVNIN 414
                 .|.|    |:|.|.       ..|..::..||      ::| ||:...|...|.:.|.|.
Human   425 -----HNELSPLKLRCQAN-------AACVDLMVWAVKDEQGAENLCIKLSEKLQSKTSSKVIIA 477

  Fly   415 EL-ICICLLNNFTGL---DPILLEQVLLDQVKRMISLTELQRQSVLYLLLCTVRRLRARLTPSLV 475
            .| :.||.|.....|   .|:::..|                                  ||||.
Human   478 HLPLLICCLQGLGRLCERFPVVVHSV----------------------------------TPSLR 508

  Fly   476 HFIFQSNPYMTK---------------VRLRSPGETSYKLLLRTCQETLLI----RNVP-LLQQA 520
            .|:...:|.:.|               :::....|.|        :.||.:    ::.| :.:|.
Human   509 DFLVIPSPVLVKLYKYHSQYHTVAGNDIKISVTNEHS--------ESTLNVMSGKKSQPSMYEQL 565

  Fly   521 YKYLVDDIDACLEKLLITAP----------------RSKARKASVLLVFH----LSALAALAKQT 565
            ....:|:|..||:..|...|                ..::.|.:.|:..|    |..:|...:.|
Human   566 RDIAIDNICRCLKAGLTVDPVIVEAFLASLSNRLYISQESDKDAHLIPDHTIRALGHIAVALRDT 630

  Fly   566 S-------SIIGMYACKPS------ILE----LLLTNCRAHELKFWSKYP----AAQQAIF---- 605
            .       .|:....|:|.      |::    |::|..:....:.|:.:.    .|...::
Human   631 PKVMEPILQILQQKFCQPPSPLDVLIIDQLGCLVITGNQYIYQEVWNLFQQISVKASSVVYSATK 695

  Fly   606 ----------GLLVVHCQANHNFRTNSSLLRDQ------------ELSAENTSPTANSFASILRF 648
                      .|.|::..||.........|.|:            .|..:..|..|:.....|:.
Human   696 DYKDHGYRHCSLAVINALANIAANIQDEHLVDELLMNLLELFVQLGLEGKRASERASEKGPALKA 760

  Fly   649 LDSVLGQAHQLAPQNLRVLLQWIQML------LRECREKIDLLME-------------------- 687
            ..|.         .||.||:..|.:|      ::|.:.::..|..
Human   761 SSSA---------GNLGVLIPVIAVLTRRLPPIKEAKPRLQKLFRDFWLYSVLMGFAVEGSGLWP 816

  Fly   688 QENFRGICRNIAATASKLVPLESAACIQTVLDYG--------------------LERLEKYPKLL 732
            :|.:.|:|.  .||.|.|:...|...:::||.|.                    :..|:..|::.
Human   817 EEWYEGVCE--IATKSPLLTFPSKEPLRSVLQYNSAMKNDTVTPAELSELRSTIINLLDPPPEVS 879

  Fly   733 ILYRDTALQQLQMLSTNYHAPYFQIYAQLPLHLTLTGGESSMPGMASRRVSVWQQRISQYS---- 793
            .|...........|.:.|...|.::.            .|:.|.........::.:..|..
Human   880 ALINKLDFAMSTYLLSVYRLEYMRVL------------RSTDPDRFQVMFCYFEDKAIQKDKSGM 932

  Fly   794 -----AVRDNVFRDFF----DRVQKPEQDSLIHCLRELFVRSCQVAPQDERQMNLSQCTKRCQRL 849
                 ||.|.||..|.    |:.:..|.:       |...|..|..     .:|.:...||.:|:
Human   933 MQCVIAVADKVFDAFLNMMADKAKTKENE-------EELERHAQFL-----LVNFNHIHKRIRRV 985

  Fly   850 A-------------IAW----------------------LQFEAARYCV-DQRLRTTVGKPQETF 878
            |             :.|                      :..:...|.: |...|.||   .:|:
Human   986 ADKYLSGLVDKFPHLLWSGTVLKTMLDILQTLSLSLSADIHKDQPYYDIPDAPYRITV---PDTY 1047

  Fly   879 LGFEAIIMRHARLLSGCAKEIERSA--LDDLSLEELLSMQSN----LSLLLGFLDALEKLI---- 933
            ...|:|:...|.......:|..:.|  :....|:|.|:...|    ||...|...|.|.::
Human  1048 EARESIVKDFAARCGMILQEAMKWAPTVTKSHLQEYLNKHQNWVSGLSQHTGLAMATESILHFAG 1112

  Fly   934 YNAAEGSAFALRPPEK-----------------------QVAAFFRLNNPTCQ-SWFNRIRIGVV 974
            ||....:..|.:..|:                       :|....|.:..|.| |..|::.:..:
Human  1113 YNKQNTTLGATQLSERPACVKKDYSNFMASLNLRNRYAGEVYGMIRFSGTTGQMSDLNKMMVQDL 1177

  Fly   975 IIAMHVQQPELVIRYAQ------QILVNSKTQDPTYSQAIVYMAWSLVSCQEADSLRGLRLW-AR 1032
            ..|:....|:   .|.|      .:|::||..||   |.:.::.|.           .||:: ..
Human  1178 HSALDRSHPQ---HYTQAMFKLTAMLISSKDCDP---QLLHHLCWG-----------PLRMFNEH 1225

  Fly  1033 GKSCKSYKWLKYAADQAAGKRESALAGYRTILAEKELQSELE-PHTRQFVVSQMMQCLQDLGQWS 1096
            |                   .|:|||.:..:||.|:   .:| |..|:...:..|...|..|.:|
Human  1226 G-------------------METALACWEWLLAGKD---GVEVPFMREMAGAWHMTVEQKFGLFS 1268

  Fly  1097 QLVELK--------QQQMTRPEDRELNP-------FLQR-------SNVEVNALERLLAKSEE-- 1137
              .|:|        :....:|...|:.|       .:||       |:.:|.....||.:|..
Human  1269 --AEIKEADPLAASEASQPKPCPPEVTPHYIWIDFLVQRFEIAKYCSSDQVEIFSSLLQRSMSLN 1331

  Fly  1138 ---SCSSMD----ALGGVFQQLSLWPSNWDESVSSSGLSERASFSSIHMRQRTEDIVLHKLLEDR 1195
               :..||:    |:|..|:.|:|            |||                     ||...
Human  1332 IGGAKGSMNRHVAAIGPRFKLLTL------------GLS---------------------LLHAD 1363

  Fly  1196 CVPDQA-KNLLDTQWRDSLLNPSFDQRSCKELTLLRHIVQGVSGGQELSLLPVSSGRCQNRSKFI 1259
            .||:.. :|:|    |:.:.:.:||..||
Human  1364 VVPNATIRNVL----REKIYSTAFDYFSC------------------------------------ 1388

  Fly  1260 SSAILMRCLAWTQLLRQHCAPGSWETLCLDAAAAAREEGNLQLAE--TLLTQFFGQPIGEIAALF 1322
                                |..:.|           :|..:|.|  :::.:|:       .|:|
Human  1389 --------------------PPKFPT-----------QGEKRLREDISIMIKFW-------TAMF 1415

  Fly  1323 S------LEQGVQTDNPEMLRGYSELVKCLHLQQQQSQTHSGDLSSSIDVCAALCLNIQKSNNQP 1381
            |      ..|.|..||.                         |..|::|:...       |..|.
Human  1416 SDKKYLTASQLVPPDNQ-------------------------DTRSNLDITVG-------SRQQA 1448

  Fly  1382 AAGADLLLNLADWIAVRTCNGLTTNQSPVLIQLLDQLPECPLTCDSSQPLAIPQAERMVARL--- 1443
            ..|         ||          |..|:                ||....|.:...|..:.
Human  1449 TQG---------WI----------NTYPL----------------SSGMSTISKKSGMSKKTNRG 1478

  Fly  1444 --VHSCLQQRPNYAEALIAYGNWCYRWGKKVADSCCVLTQADATAISQALDIPQPLESEKLDELL 1506
              :|....:|.....:|:                        ||.|.:.:....||.:.:| ||
Human  1479 SQLHKYYMKRRTLLLSLL------------------------ATEIERLITWYNPLSAPEL-EL- 1517

  Fly  1507 QALSTEQPPANCVEVCPDAARARDDEAAKNRLRRLTFLADKTPEALDAILQIWR-RAIANTYDYY 1570
                                    |:|.:|.:..                  || :.|:.:...:
Human  1518 ------------------------DQAGENSVAN------------------WRSKYISLSEKQW 1540

  Fly  1571 KD---AARSYFQYLSFKSGSGPEKPEGEGVVSQRERLHVDDSNLVTTTLRLLRLIVKHASGLQEV 1632
            ||   .|.|...||:.:..:..:..|..|             |.||   ||:||.....|.:.|.
Human  1541 KDNVNLAWSISPYLAVQLPARFKNTEAIG-------------NEVT---RLVRLDPGAVSDVPEA 1589

  Fly  1633 LEQGLHTTPIAPWKVI---IPQLFSRLNHHEPYVRKSVCDLLCRLAKSRPQ-LVIFPAVVGANRE 1693
            ::.      :..|..|   .|:    |:|           :||......|. |..|.::.
Human  1590 IKF------LVTWHTIDADAPE----LSH-----------VLCWAPTDPPTGLSYFSSMY----- 1628

  Fly  1694 QQDATAPPATARPTTEDACCYGYLLGELSKQAPEAVQ-HVKLMVKELR-------RVCLLWDEYW 1750
                  ||   .|.|..   ||..:  |....|:|:. ::..:|:.||       |..:||....
Human  1629 ------PP---HPLTAQ---YGVKV--LRSFPPDAILFYIPQIVQALRYDKMGYVREYILWAASK 1679

  Fly  1751 IHSLAHIY------NTYVSRVSALATDFRPDDHEGKNNRFNVWRPQLLADL-EALVAVTSRPPET 1808
            ...|||.:      |.|:             |.||.....::  ..||..| |.:....|.|.:.
Human  1680 SQLLAHQFIWNMKTNIYL-------------DEEGHQKDPDI--GDLLDQLVEEITGSLSGPAKD 1729

  Fly  1809 TYERSFRKRFDAPIRLTVDALRHRRYPEAWDKLKQLYHILQSNMIR------------------G 1855
            .|:|    .||...::|..:...:.||:..::.|.....|....::                  .
Human  1730 FYQR----EFDFFNKITNVSAIIKPYPKGDERKKACLSALSEVKVQPGCYLPSNPEAIVLDIDYK 1790

  Fly  1856 SGSTLKMQSISPVL-------CGIGRMRISMPGLDAHGPDGDQVYIESVESSVCVLPTKTKPKKV 1913
            ||:.::..:.:|.|       ||:.  .:...||.......|:...:.
Human  1791 SGTPMQSAAKAPYLAKFKVKRCGVS--ELEKEGLRCRSDSEDECSTQE----------------- 1836

  Fly  1914 AFYGSNGQRYTF---LFKGMEDLHLDERIMQFLSISNAIMACRSDAPGNGCYRAHHYSVIPLGPQ 1975
                ::||:.::   :||..:|...|...:|.:.:...|.    ...|...: ...|.|:...|.
Human  1837 ----ADGQKISWQAAIFKVGDDCRQDMLALQIIDLFKNIF----QLVGLDLF-VFPYRVVATAPG 1892

  Fly  1976 SGLISWVDGVTPVFALYKKWQQRRSQVAGNAGAGAVANVPRRFTDLFYNKLSPLLAKHNMQVSDP 2040
            .|:|..:...|           .|.|:......|......|::.|
Human  1893 CGVIECIPDCT-----------SRDQLGRQTDFGMYDYFTRQYGD-------------------- 1926

  Fly  2041 RRQWPISVLLQVLDELSQETPNDLLARELWCQAGNAAEWRQSVRRFVRCMSVMSMIGYVIGLGDR 2105
                                 ...||            ::|:...|:|.|:..|::.:::.:.||
Human  1927 ---------------------ESTLA------------FQQARYNFIRSMAAYSLLLFLLQIKDR 1958

  Fly  2106 HLDNVLINLGSGDIVHIDYNVCFEKGRTLRIPEKVPFRLTQNLVQAMGITGIEGPFRLGCEYVLK 2170
            |..|:::: ..|.|:|||:...||......:..:...:||..:|..||......||:...|..::
Human  1959 HNGNIMLD-KKGHIIHIDFGFMFESSPGGNLGWEPDIKLTDEMVMIMGGKMEATPFKWFMEMCVR 2022

  Fly  2171 ---VMRKERETLLTLL 2183
               .:|...:.:::|:
Human  2023 GYLAVRPYMDAVVSLV 2038

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nonC	NP_001284967.1	SMG1	571..1140	CDD:292413	133/772 (17%)
		Rapamycin_bind	1738..1845	CDD:285924	27/120 (23%)
		PIKKc_SMG1	1894..2196	CDD:270714	48/296 (16%)
		FATC	3189..3217	CDD:280430
PI4KA	NP_477352.3	PI4Ka	1547..1722	CDD:238443	52/245 (21%)
		PI4Kc_III_alpha	1783..2101	CDD:270711	57/349 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900