DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nonC and PIK3CD

DIOPT Version :9

Sequence 1:	NP_001284967.1	Gene:	nonC / 31625	FlyBaseID:	FBgn0263968	Length:	3218	Species:	Drosophila melanogaster
Sequence 2:	XP_016856965.1	Gene:	PIK3CD / 5293	HGNCID:	8977	Length:	1103	Species:	Homo sapiens

Alignment Length:	1307	Identity:	251/1307 - (19%)
Similarity:	404/1307 - (30%)	Gaps:	478/1307 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly  1147 GVFQQLSLWPSNWDESVSSSGL-----------SERASFSSI--------------HMRQRTEDI 1186
            ||...:..|....::||....|           |..|:.|:|              ||....|..
Human     4 GVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAY 68

  Fly  1187 V---LHKLLEDRCVPDQAKNLLDTQ---------WRD-----SLLNPSFDQRSCKELTLLRHIVQ 1234
            |   :::..|.:.:.|:.:.|.|.|         .|:     .|:|        .:::||  |.:
Human    69 VFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLIN--------SQISLL--IGK 123

  Fly  1235 GVSGGQELSLLPVSSGR---CQNRSKFISSAILMR-CLAWTQLLRQHCAPGSWETLCLDAAAAAR 1295
            |:.....|....|:..|   ||    |...|...| .|.|...| |:..|     |.|:.:|...
Human   124 GLHEFDSLCDPEVNDFRAKMCQ----FCEEAAARRQQLGWEAWL-QYSFP-----LQLEPSAQTW 178

  Fly  1296 EEGNLQLAETLL----------------------------------TQFFGQPIGEIAALFSLEQ 1326
            ..|.|:|....|                                  ...|.||:.|....::|:
Human   179 GPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQ- 242

  Fly  1327 GVQTDNPEMLRG------YSELVKCLH--LQQQQSQTHSGDLSSSIDVCAALCLNIQKSNNQPAA 1383
              .....|.|.|      :..:..|||  |....:..||..:.:..|..:.....:||...:|..
Human   243 --VNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPP 305

  Fly  1384 GADLLLNLADWIAVRTCNGLTTNQSPVLIQLLDQLPECPLTCDSSQPLAIPQAERMVARLVHSCL 1448
                       |..:       ..|.|.:..|:|    |...:..|...:...|||  :||
Human   306 -----------IPAK-------KPSSVSLWSLEQ----PFRIELIQGSKVNADERM--KLV---- 342

  Fly  1449 QQRPNYAEALIAYGNWCYRWGKKVADSCCVLTQADATAISQALDIPQPLESEKLDELLQALSTEQ 1513
                  .:|.:.:||...         |..::.::.:..|      :|:..::|:..:......:
Human   343 ------VQAGLFHGNEML---------CKTVSSSEVSVCS------EPVWKQRLEFDINICDLPR 386

  Fly  1514 PPANCVEVCPDAARARDDEAAKNRLRRLTFLADKTPEALDAILQIWRRAIANTY-DYYKDAARSY 1577
            ....|..:.....:|:...:.|.:.::    || .|.|       |...:...| |..|...|..
Human   387 MARLCFALYAVIEKAKKARSTKKKSKK----AD-CPIA-------WANLMLFDYKDQLKTGERCL 439

  Fly  1578 FQYLSFKSGSGP-------------------------------------EKPEGEGVVSQRE--- 1602
            :.:.|.....|.                                     ||..|..:::.||
Human   440 YMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKLPGGMLLASREWRP 504

  Fly  1603 -----RLHVDDS------NLVTTTLRLLRLIVK-----HASGLQEVLEQGLHTTPI--------- 1642
                 |||.:||      .:....|.:|..:|:     ..|.|.::||.|.|:..:
Human   505 ELLWMRLHAEDSAPSRMIGVAMPGLGVLPGLVQAPGDAECSRLLQILELGRHSECVHVTEEEQLQ 569

  Fly  1643 -------------------APWKV------IIPQLFSRL------NHHEPYVRKSVCDLLCRLAK 1676
                               ..||:      ..|:..:||      |.||...:  :..|||
Human   570 LREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQ--MLYLLC---- 628

  Fly  1677 SRPQLVIFPAVVGANREQQDATAPPA--------TARPTTEDACCYGYLLGELSKQAPEAVQHVK 1733
            |.|:|.:..|:     |..|.:.|..        :.|..|:|                |..|::.
Human   629 SWPELPVLSAL-----ELLDFSFPDCHVGSFAIKSLRKLTDD----------------ELFQYLL 672

  Fly  1734 LMVKELRRVCLLWDEYWIHSLAHIYNTYVSRVSALATDFRPDD--HEGKNNRFNVW--RPQLLAD 1794
            .:|:.|:                    |.|.:....|.|..|.  ...|...|..|  |.::...
Human   673 QLVQVLK--------------------YESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVP 717

  Fly  1795 LEALVAVTSRPPETTYERSFRKRFDAPIRLTVDALRHR-----RYPEAWDKLKQLYHILQSNMIR 1854
            ..||                  ||...:........|.     :..||..|||.|...::.:
Human   718 SVAL------------------RFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLS--- 761

  Fly  1855 GSGSTLKMQSISPV-LCGIGRMRISMPGLDAHGPDGDQVYIESVE------------SSVCV--- 1903
             |..|.|.|:...: ||    ||             .:.|:|::.            :.|||
Human   762 -SQKTPKPQTKELMHLC----MR-------------QEAYLEALSHLQSPLDPSTLLAEVCVEQC 808

  Fly  1904 --LPTKTKPKKVAF----YGSNGQRYTFLFKGMEDLHLDERIMQFLSISNAIMACRSDAPGNGC- 1961
              :.:|.||..:.:    .||.|. ...:||..:||..|...:|.:.:.:.:.      ...|.
Human   809 TFMDSKMKPLWIMYSNEEAGSGGS-VGIIFKNGDDLRQDMLTLQMIQLMDVLW------KQEGLD 866

  Fly  1962 YRAHHYSVIPLGPQSGLISWV---DGVTPVFALYKKWQQRRSQVAGNAGAGAVANVPRRFTDLFY 2023
            .|...|..:|.|.::|||..|   |.:..:       |..:|.:|..|.               :
Human   867 LRMTPYGCLPTGDRTGLIEVVLRSDTIANI-------QLNKSNMAATAA---------------F 909

  Fly  2024 NKLSPLLAKHNMQVSDPRRQWPISVLLQVLDELSQETPNDLLARELWCQAGNAAEWRQSVRRFVR 2088
            ||             |....|           |..:.|.:.|.|              ::..|..
Human   910 NK-------------DALLNW-----------LKSKNPGEALDR--------------AIEEFTL 936

  Fly  2089 CMSVMSMIGYVIGLGDRHLDNVLINLGSGDIVHIDYNVCFEKGRTL----RIPEKVPFRLTQNLV 2149
            ..:...:..||:|:||||.||::|. .||.:.|||:.......:|.    |  |:|||.||.:.|
Human   937 SCAGYCVATYVLGIGDRHSDNIMIR-ESGQLFHIDFGHFLGNFKTKFGINR--ERVPFILTYDFV 998

  Fly  2150 QAM--GITGIEGP---FRLGCEYVLKVMRKERETLLTLLEAFVYDPLVDWTTNDDAQALRRSLN- 2208
            ..:  |.|.....   ||..||....::|:.....|.|........|.:.:.:.|.|.|:.||.
Human   999 HVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLAL 1063

  Fly  2209 AKLQESA 2215
            .|.:|.|
Human  1064 GKTEEEA 1070

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nonC	NP_001284967.1	SMG1	571..1140	CDD:292413
		Rapamycin_bind	1738..1845	CDD:285924	20/115 (17%)
		PIKKc_SMG1	1894..2196	CDD:270714	73/335 (22%)
		FATC	3189..3217	CDD:280430
PIK3CD	XP_016856965.1	PI3K_p85B	32..107	CDD:308030	14/74 (19%)
		PI3K_rbd	175..281	CDD:307097	19/108 (18%)
		C2_PI3K_class_I_beta_delta	314..481	CDD:176075	31/209 (15%)
		PI3Ka	562..743	CDD:214537	39/245 (16%)
		PI3Kc_IA_delta	735..1101	CDD:270718	97/427 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900